dc.contributor.advisor | Peterson, Catherine Ann | eng |
dc.contributor.author | Heffernan, Mary Elizabeth | eng |
dc.date.issued | 2007 | eng |
dc.date.submitted | 2007 Fall | eng |
dc.description | The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. | eng |
dc.description | Title from PDF of title page (University of Missouri--Columbia, viewed September 10, 2009). | eng |
dc.description | Thesis advisor: Dr. Catherine Peterson. | eng |
dc.description | Includes bibliographical references. | eng |
dc.description | M.S. University of Missouri--Columbia 2007. | eng |
dc.description | Dissertations, Academic -- University of Missouri--Columbia -- Nutrition area program. | eng |
dc.description.abstract | Vitamin D is synthesized in the skin in response to UVB radiation and has an essential function in optimal bone health. Recent evidence has also implicated a role for vitamin D in a properly functioning immune system. The objective of this study was to determine the relationship between vitamin D status, inflammatory markers, and bone mineral density in healthy pre- and post-menopausal women who regularly use tanning beds. This observational study examined 69 healthy female subjects: 49 Tanners and 20 Non-Tanners. Subjects provided medical and dietary information, a blood specimen, and bone mineral density was measured. Blood specimens were analyzed for serum 25(OH)D, parathyroid hormone (iPTH), estradiol (E2), cortisol, and inflammatory markers. Results: Tanners had serum 25(OH)D concentrations that were significantly higher (P [less than] 0.0001) and iPTH concentrations that were significantly lower (P [less than] 0.0001) than Non-Tanners. There were no differences in bone density between groups. Tanners had significantly lower serum TNF[alpha] (P [less than] 0.0200) and a linear regression revealed that 25(OH)D had a significant inverse relationship with TNF[alpha] (P [less than] 0.0463), which remained significant after controlling for potential covariates. Conclusions: Serum 25(OH)D status is inversely related to TNF[alpha] concentrations in healthy women, which may in part explain its role in the prevention and treatment of numerous diseases. | eng |
dc.identifier.merlin | b70796427 | eng |
dc.identifier.oclc | 436768701 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/5024 | |
dc.identifier.uri | https://doi.org/10.32469/10355/5024 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.subject.lcsh | Vitamin D in human nutrition | eng |
dc.subject.lcsh | Suntan | eng |
dc.subject.lcsh | Bones -- Diseases | eng |
dc.subject.lcsh | Women -- Diseases | eng |
dc.title | The effects of regular tanning bed use and increased vitamin D status on bone mineral density and serum inflammatory markers in healthy women | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Nutrition area program (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Masters | eng |
thesis.degree.name | M.S. | eng |