Modeling of phototransduction in vision systems

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Modeling of phototransduction in vision systems

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/5030

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dc.contributor.advisor Tan, Jinglu, 1958- en
dc.contributor.author Lu, Lei, 1968- en_US
dc.date.accessioned 2010-01-12T19:08:38Z
dc.date.available 2010-01-12T19:08:38Z
dc.date.issued 2007 en_US
dc.date.submitted 2007 Fall en
dc.identifier.other LuL-103107-T8467 en_US
dc.identifier.uri http://hdl.handle.net/10355/5030
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Title from title screen of research.pdf file (viewed on April 1, 2008) en_US
dc.description Includes bibliographical references. en_US
dc.description Thesis (M.S.) University of Missouri-Columbia 2007. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Biological engineering. en_US
dc.description.abstract To improve the usefulness of the electroretinogram (ERG) in identifying the sites and mechanisms of adaptation, development and disease processes, a quantitative model was developed based on the biochemical reaction kinetics in the phototransduction cascade and experimental data. A set of differential equations were derived to predict the electrical response of photoreceptors to light and system identification was employed to determine the model parameters. When applied to wild-type and retina-damaged mice, the proposed model effectively described the ERG a-wave over a range of light intensities and different stimulus patterns. From the model parameters, the retina-damaged subjects could be differentiated from the normal ones. It is anticipated that this model could help detect changes in the phototransduction process and enhance the utility of ERG in the clinic. It also provides insights into dynamics of the vision system. en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.subject phototransduction; vision system. en_US
dc.subject phototransduction; vision system en_US
dc.subject.lcsh Electroretinography -- Mathematical models en_US
dc.subject.lcsh Eye -- Examination en_US
dc.subject.lcsh Cellular signal transduction en_US
dc.subject.lcsh Neural transmission en_US
dc.title Modeling of phototransduction in vision systems en_US
dc.type Thesis en_US
thesis.degree.discipline Biological engineering en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name M.S. en_US
thesis.degree.level Masters en_US
dc.identifier.merlin .b6301788x en_US
dc.identifier.oclc 216928820 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theses
dc.relation.ispartofcollection 2007 Freely available theses (MU)


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