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dc.contributor.advisorTan, Jinglu, 1958-en
dc.contributor.authorLu, Lei, 1968-en_US
dc.date.issued2007eng
dc.date.submitted2007 Fallen
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.en_US
dc.descriptionTitle from title screen of research.pdf file (viewed on April 1, 2008)en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2007.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Biological engineering.en_US
dc.description.abstractTo improve the usefulness of the electroretinogram (ERG) in identifying the sites and mechanisms of adaptation, development and disease processes, a quantitative model was developed based on the biochemical reaction kinetics in the phototransduction cascade and experimental data. A set of differential equations were derived to predict the electrical response of photoreceptors to light and system identification was employed to determine the model parameters. When applied to wild-type and retina-damaged mice, the proposed model effectively described the ERG a-wave over a range of light intensities and different stimulus patterns. From the model parameters, the retina-damaged subjects could be differentiated from the normal ones. It is anticipated that this model could help detect changes in the phototransduction process and enhance the utility of ERG in the clinic. It also provides insights into dynamics of the vision system.en_US
dc.identifier.merlin.b6301788xen_US
dc.identifier.oclc216928820en_US
dc.identifier.otherLuL-103107-T8467en_US
dc.identifier.urihttp://hdl.handle.net/10355/5030
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartofcollection2007 Freely available theses (MU)
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theses
dc.subjectphototransduction; vision system.en_US
dc.subjectphototransduction; vision systemen_US
dc.subject.lcshElectroretinography -- Mathematical modelsen_US
dc.subject.lcshEye -- Examinationen_US
dc.subject.lcshCellular signal transductionen_US
dc.subject.lcshNeural transmissionen_US
dc.titleModeling of phototransduction in vision systemsen_US
dc.typeThesisen_US
thesis.degree.disciplineBiological engineeringeng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMastersen_US
thesis.degree.nameM.S.en_US


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