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dc.contributor.advisorTan, Jinglu, 1958-eng
dc.contributor.authorLu, Lei, 1968-eng
dc.date.issued2007eng
dc.date.submitted2007 Falleng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on April 1, 2008)eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2007.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Biological engineering.eng
dc.description.abstractTo improve the usefulness of the electroretinogram (ERG) in identifying the sites and mechanisms of adaptation, development and disease processes, a quantitative model was developed based on the biochemical reaction kinetics in the phototransduction cascade and experimental data. A set of differential equations were derived to predict the electrical response of photoreceptors to light and system identification was employed to determine the model parameters. When applied to wild-type and retina-damaged mice, the proposed model effectively described the ERG a-wave over a range of light intensities and different stimulus patterns. From the model parameters, the retina-damaged subjects could be differentiated from the normal ones. It is anticipated that this model could help detect changes in the phototransduction process and enhance the utility of ERG in the clinic. It also provides insights into dynamics of the vision system.eng
dc.identifier.merlin.b6301788xeng
dc.identifier.oclc216928820eng
dc.identifier.otherLuL-103107-T8467eng
dc.identifier.urihttp://hdl.handle.net/10355/5030eng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollection2007 Freely available theses (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theseseng
dc.source.originalSubmitted by University of Missouri--Columbia Graduate School.eng
dc.subjectphototransduction; vision system.eng
dc.subjectphototransduction; vision systemeng
dc.subject.lcshElectroretinography -- Mathematical modelseng
dc.subject.lcshEye -- Examinationeng
dc.subject.lcshCellular signal transductioneng
dc.subject.lcshNeural transmissioneng
dc.titleModeling of phototransduction in vision systemseng
dc.typeThesiseng
thesis.degree.disciplineBiological engineering (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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