[-] Show simple item record

dc.contributor.advisorReinero, Carol R.en
dc.contributor.authorSchooley, Elizabeth K.en_US
dc.date.issued2007eng
dc.date.submitted2007 Springen
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.en_US
dc.descriptionVita.en_US
dc.description"May 2007"en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2007.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary medicine and surgery.en_US
dc.description.abstractUse of cyproheptadine, a serotonin antagonist, and cetirizine a selective histamine (H1) antagonist, in feline asthma has not been previously described. We tested the hypotheses 1) 5 mg of oral cetirizine would be adequately absorbed by the cat and would reach therapeutic levels 2) oral cyproheptadine and cetirizine would blunt eosinophilc airway inflammation in cats sensitized to BGA. For hypothesis 1, heparinized blood (2 mL) was collected from 9 cats at baseline, and at 0.5, 1, 2, 4, 6, 8, 10 and 24 hours after oral administration of 5 mg of cetirizine. A reverse-phase HPLC assay was developed. The plasma concentrations were analyzed with a compartmental pharmacokinetic model. For hypothesis 2, nine research cats were sensitized to BGA. Cats received 1 week treatments of placebo, cyproheptadine or cetirizine. On day 7 of each treatment period, cats were anesthetized for sample collection. BALF % eosinophils was determined. ELISAs were performed to evaluate blood and BALF immunoglobulin, IL-4 and IL-10, histamine concentrations. Plasma and BALF serotonin was measured using a fluorometric method. Results: hypothesis 1- Mean plasma concentrations of cetirizine were maintained above 0.85 mcg/mL for 24 hours; hypothesis 2- No significant difference between treatment groups was found with respect percent BALF eosinophils or the other measured immunologic variables. These results indicate that a single dose of cetirizine administered orally to cats produced high plasma concentrations compared to what has been reported in humans. Administration of cyproheptadine and cetirizine did not decrease airway eosinophilia or alter other immune variables.en_US
dc.identifier.merlin.b66787312en_US
dc.identifier.oclc318651468en_US
dc.identifier.otherSchooleyE-042507-T6384en_US
dc.identifier.urihttp://hdl.handle.net/10355/5033
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2007 Freely available theses (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theses
dc.subject.lcshCats -- Respiratory organs -- Diseasesen_US
dc.subject.lcshAsthmaen_US
dc.subject.lcshSerotonin -- Antagonists -- Therapeutic useen_US
dc.subject.lcshAntihistamines -- Therapeutic useen_US
dc.titleThe effects of an antiseritonergic drug and antihistamine in an experimental model of feline asthmaen_US
dc.typeThesisen_US
thesis.degree.disciplineVeterinary medicine and surgeryen_US
thesis.degree.disciplineVeterinary medicine and surgeryeng
thesis.degree.grantorUniversity of Missouri--Columbiaen_US
thesis.degree.levelMastersen_US
thesis.degree.nameM.S.en_US


Files in this item

[PDF]
[PDF]
[PDF]

This item appears in the following Collection(s)

[-] Show simple item record