The effects of an antiseritonergic drug and antihistamine in an experimental model of feline asthma

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The effects of an antiseritonergic drug and antihistamine in an experimental model of feline asthma

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/5033

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dc.contributor.advisor Reinero, Carol R. en
dc.contributor.author Schooley, Elizabeth K. en_US
dc.date.accessioned 2010-01-12T19:08:41Z
dc.date.available 2010-01-12T19:08:41Z
dc.date.issued 2007 en_US
dc.date.submitted 2007 Spring en
dc.identifier.other SchooleyE-042507-T6384 en_US
dc.identifier.uri http://hdl.handle.net/10355/5033
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Vita. en_US
dc.description "May 2007" en_US
dc.description Includes bibliographical references. en_US
dc.description Thesis (M.S.) University of Missouri-Columbia 2007. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Veterinary medicine and surgery. en_US
dc.description.abstract Use of cyproheptadine, a serotonin antagonist, and cetirizine a selective histamine (H1) antagonist, in feline asthma has not been previously described. We tested the hypotheses 1) 5 mg of oral cetirizine would be adequately absorbed by the cat and would reach therapeutic levels 2) oral cyproheptadine and cetirizine would blunt eosinophilc airway inflammation in cats sensitized to BGA. For hypothesis 1, heparinized blood (2 mL) was collected from 9 cats at baseline, and at 0.5, 1, 2, 4, 6, 8, 10 and 24 hours after oral administration of 5 mg of cetirizine. A reverse-phase HPLC assay was developed. The plasma concentrations were analyzed with a compartmental pharmacokinetic model. For hypothesis 2, nine research cats were sensitized to BGA. Cats received 1 week treatments of placebo, cyproheptadine or cetirizine. On day 7 of each treatment period, cats were anesthetized for sample collection. BALF % eosinophils was determined. ELISAs were performed to evaluate blood and BALF immunoglobulin, IL-4 and IL-10, histamine concentrations. Plasma and BALF serotonin was measured using a fluorometric method. Results: hypothesis 1- Mean plasma concentrations of cetirizine were maintained above 0.85 mcg/mL for 24 hours; hypothesis 2- No significant difference between treatment groups was found with respect percent BALF eosinophils or the other measured immunologic variables. These results indicate that a single dose of cetirizine administered orally to cats produced high plasma concentrations compared to what has been reported in humans. Administration of cyproheptadine and cetirizine did not decrease airway eosinophilia or alter other immune variables. en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2007 Freely available theses (MU) en_US
dc.subject.lcsh Cats -- Respiratory organs -- Diseases en_US
dc.subject.lcsh Asthma en_US
dc.subject.lcsh Serotonin -- Antagonists -- Therapeutic use en_US
dc.subject.lcsh Antihistamines -- Therapeutic use en_US
dc.title The effects of an antiseritonergic drug and antihistamine in an experimental model of feline asthma en_US
dc.type Thesis en_US
thesis.degree.discipline Veterinary medicine and surgery en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name M.S. en_US
thesis.degree.level Masters en_US
dc.identifier.merlin .b66787312 en_US
dc.identifier.oclc 318651468 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theses


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