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dc.contributor.advisorAlmasri, Mahmouden
dc.contributor.authorKorampally, Madhurien_US
dc.date.issued2007en_US
dc.date.submitted2007 Fallen
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.en_US
dc.descriptionTitle from title screen of research.pdf file (viewed on March 28, 2008)en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2007.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Animal sciences.en_US
dc.description.abstractDetection and classification of cells forms an important aspect of medical research in diagnosing diseases and finding remedies at the cellular level. Miniaturized cell detecting devices are desirable not only for on site biomedical analysis but also for in situ monitoring of cell dynamics. This research presents the design and fabrication of a MEMS based Coulter counter for monitoring cellular volumetric changes after an exposure to various media. The device is based on three important phenomena: 1) Passive mixing of the reagents, 2) Dielectrophoretic focusing of the cells and 3) Electrical impedance based sensing mechanism. This device improves upon existing macro-scale Coulter counter technology by allowing extremely small sample sizes (101 compared to 105 cells per experiment), an extremely short time frame from the exposure to reactant media to the initial measurement, serial time series measurements of a single cell, and optical microscopic monitoring of the experiment. Finally, the design of this device will allow for the manufacture of cell specific channel diameters in order to maximize measurement precision for each cell type.en_US
dc.identifier.merlin.b63012030en_US
dc.identifier.oclc216683885en_US
dc.identifier.otherKorampallyM-120607-T8689en_US
dc.identifier.urihttp://hdl.handle.net/10355/5079
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2007 Freely available theses (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theses
dc.subject.lcshCells -- Classificationen_US
dc.subject.lcshCells -- Measurement -- Mathematical modelsen_US
dc.subject.lcshMiniature electronic equipmenten_US
dc.subject.lcshMicroelectromechanical systemsen_US
dc.titleA MEMS based Coulter counter for cell sizingen_US
dc.typeThesisen_US
thesis.degree.disciplineAnimal scienceseng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMastersen_US
thesis.degree.nameM.S.en_US


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