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dc.contributor.advisorAlmasri, Mahmoudeng
dc.contributor.authorKorampally, Madhurieng
dc.date.issued2007eng
dc.date.submitted2007 Falleng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on March 28, 2008)eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2007.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Animal sciences.eng
dc.description.abstractDetection and classification of cells forms an important aspect of medical research in diagnosing diseases and finding remedies at the cellular level. Miniaturized cell detecting devices are desirable not only for on site biomedical analysis but also for in situ monitoring of cell dynamics. This research presents the design and fabrication of a MEMS based Coulter counter for monitoring cellular volumetric changes after an exposure to various media. The device is based on three important phenomena: 1) Passive mixing of the reagents, 2) Dielectrophoretic focusing of the cells and 3) Electrical impedance based sensing mechanism. This device improves upon existing macro-scale Coulter counter technology by allowing extremely small sample sizes (101 compared to 105 cells per experiment), an extremely short time frame from the exposure to reactant media to the initial measurement, serial time series measurements of a single cell, and optical microscopic monitoring of the experiment. Finally, the design of this device will allow for the manufacture of cell specific channel diameters in order to maximize measurement precision for each cell type.eng
dc.identifier.merlin.b63012030eng
dc.identifier.oclc216683885eng
dc.identifier.otherKorampallyM-120607-T8689eng
dc.identifier.urihttp://hdl.handle.net/10355/5079eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.subject.lcshCells -- Classificationeng
dc.subject.lcshCells -- Measurement -- Mathematical modelseng
dc.subject.lcshMiniature electronic equipmenteng
dc.subject.lcshMicroelectromechanical systemseng
dc.titleA MEMS based Coulter counter for cell sizingeng
dc.typeThesiseng
thesis.degree.disciplineAnimal sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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