A MEMS based Coulter counter for cell sizing

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A MEMS based Coulter counter for cell sizing

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/5079

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dc.contributor.advisor Almasri, Mahmoud en
dc.contributor.author Korampally, Madhuri en_US
dc.date.accessioned 2010-01-12T19:09:36Z
dc.date.available 2010-01-12T19:09:36Z
dc.date.issued 2007 en_US
dc.date.submitted 2007 Fall en
dc.identifier.other KorampallyM-120607-T8689 en_US
dc.identifier.uri http://hdl.handle.net/10355/5079
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Title from title screen of research.pdf file (viewed on March 28, 2008) en_US
dc.description Includes bibliographical references. en_US
dc.description Thesis (M.S.) University of Missouri-Columbia 2007. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Animal sciences. en_US
dc.description.abstract Detection and classification of cells forms an important aspect of medical research in diagnosing diseases and finding remedies at the cellular level. Miniaturized cell detecting devices are desirable not only for on site biomedical analysis but also for in situ monitoring of cell dynamics. This research presents the design and fabrication of a MEMS based Coulter counter for monitoring cellular volumetric changes after an exposure to various media. The device is based on three important phenomena: 1) Passive mixing of the reagents, 2) Dielectrophoretic focusing of the cells and 3) Electrical impedance based sensing mechanism. This device improves upon existing macro-scale Coulter counter technology by allowing extremely small sample sizes (101 compared to 105 cells per experiment), an extremely short time frame from the exposure to reactant media to the initial measurement, serial time series measurements of a single cell, and optical microscopic monitoring of the experiment. Finally, the design of this device will allow for the manufacture of cell specific channel diameters in order to maximize measurement precision for each cell type. en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2007 Freely available theses (MU) en_US
dc.subject.lcsh Cells -- Classification en_US
dc.subject.lcsh Cells -- Measurement -- Mathematical models en_US
dc.subject.lcsh Miniature electronic equipment en_US
dc.subject.lcsh Microelectromechanical systems en_US
dc.title A MEMS based Coulter counter for cell sizing en_US
dc.type Thesis en_US
thesis.degree.discipline Animal sciences en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name M.S. en_US
thesis.degree.level Masters en_US
dc.identifier.merlin .b63012030 en_US
dc.identifier.oclc 216683885 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theses


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