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    • 2007 MU theses - Freely available online
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    Synthesis and characterization of novel phosphinimine ligand systems for potential applications in radiopharmaceuticals

    Pandrapragada, Ravi Kumar, 1975-
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    Date
    2007
    Format
    Thesis
    Metadata
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    Abstract
    Multidentate phosphinimine ligands, C₂₅H₄₉N₂P₂Si₂,(2) C₃₄H₃₈N₂P₂Si₂(3), and C₅₀H₆₆N₃P₃Si₃(4), were synthesized in near quantitative yields by Staudinger reaction using appropriate phosphines. Coordination chemistry of 2 and 3 with Re was performed and the X-ray crystallographic study of the Re ion-pair complex of ligand 2 is reported. Radiolabeling of ligands 2, 3 and 4 with ⁹⁹[superscript]mTc was performed. Simple mixing of ligand solutions with aqueous ⁹⁹[superscript]mTcO₄⁻ in saline solution produced ion-pairs with more than 95% yields. All three ion-pairs produced are stable for more than 24 h in organic media and in alcohols. The ion-pair produced with ligand 3 ([(NH₂PPh₂CH₂PPh₂NH or O)⁺ (⁹⁹[superscript]mTcO₄)⁻] ), upon heating has resulted in the neutral complex [(NH₂PPh₂CH₂PPh₂NH or O)⁺ (⁹⁹[superscript]mTcO3)]. Upon heating the ion-pair ([(NH2PPh2CH2PPh2NH)+ (ReO4)-] in the presence of Verkade's superbase led to the rearrangement of the ligand via cleavage of the P-C-P bridge to produce P-N-P bridged compound.
    URI
    https://hdl.handle.net/10355/5100
    https://doi.org/10.32469/10355/5100
    Degree
    M.S.
    Thesis Department
    Chemistry (MU)
    Collections
    • 2007 MU theses - Freely available online
    • Chemistry electronic theses and dissertations (MU)

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