dc.contributor.advisor | Katti, Kattesh V. | eng |
dc.contributor.advisor | Jurisson, Silvia S. (Silvia Sabine) | eng |
dc.contributor.author | Pandrapragada, Ravi Kumar, 1975- | eng |
dc.date.issued | 2007 | eng |
dc.date.submitted | 2007 Spring | eng |
dc.description | The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. | eng |
dc.description | Title from title screen of research.pdf file (viewed on November 1, 2007) | eng |
dc.description | Vita. | eng |
dc.description | Includes bibliographical references. | eng |
dc.description | Thesis (M.S.) University of Missouri-Columbia 2007. | eng |
dc.description | Dissertations, Academic -- University of Missouri--Columbia -- Chemistry. | eng |
dc.description.abstract | Multidentate phosphinimine ligands, C₂₅H₄₉N₂P₂Si₂,(2) C₃₄H₃₈N₂P₂Si₂(3), and C₅₀H₆₆N₃P₃Si₃(4), were synthesized in near quantitative yields by Staudinger reaction using appropriate phosphines. Coordination chemistry of 2 and 3 with Re was performed and the X-ray crystallographic study of the Re ion-pair complex of ligand 2 is reported. Radiolabeling of ligands 2, 3 and 4 with ⁹⁹[superscript]mTc was performed. Simple mixing of ligand solutions with aqueous ⁹⁹[superscript]mTcO₄⁻ in saline solution produced ion-pairs with more than 95% yields. All three ion-pairs produced are stable for more than 24 h in organic media and in alcohols. The ion-pair produced with ligand 3 ([(NH₂PPh₂CH₂PPh₂NH or O)⁺ (⁹⁹[superscript]mTcO₄)⁻] ), upon heating has resulted in the neutral complex [(NH₂PPh₂CH₂PPh₂NH or O)⁺ (⁹⁹[superscript]mTcO3)]. Upon heating the ion-pair ([(NH2PPh2CH2PPh2NH)+ (ReO4)-] in the presence of Verkade's superbase led to the rearrangement of the ligand via cleavage of the P-C-P bridge to produce P-N-P bridged compound. | eng |
dc.identifier.merlin | b61227109 | eng |
dc.identifier.oclc | 180187608 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/5100 | |
dc.identifier.uri | https://doi.org/10.32469/10355/5100 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2007 Theses | eng |
dc.subject.lcsh | Phosphine | eng |
dc.subject.lcsh | Imines | eng |
dc.subject.lcsh | Radiopharmaceuticals | eng |
dc.subject.lcsh | Technetium | eng |
dc.title | Synthesis and characterization of novel phosphinimine ligand systems for potential applications in radiopharmaceuticals | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Chemistry (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Masters | eng |
thesis.degree.name | M.S. | eng |