RSS 1.0Department of Chemistry (MU)
The Department of Chemistry at the College of Arts and Sciences University of Missouri-Columbia offers Graduate and Undergraduate degree programs and houses multiple research facilities.
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(4+3)-cycloaddition chemists of oxidopyridinium ions and related study
(University of Missouri--Columbia, 2019)The (4+3)-cycloaddition reaction is a cycloaddition between a 4-atom species and a 3-atom species to form a seven-membered ring. This reaction results in the formation of seven-membered rings. Our research expanded the ... -
Investigating reaction conditions for controlling the self-assembly of metal-seamed pyrogallol[4]arene nanocapsules
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Upon coordination to metal ions, C-alkylpyrogallol[4]arenes (PgCn, where n is the number of carbon atoms in the pendant alkyl chains), can be assembled ... -
Structural, biochemical, and inhibition studies of proline biosynthetic enzymes
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of [Delta]1-pyrroli ... -
Novel DNA Adducts- Chemical Reactions that Model the Generation of interstrand cross-links between a Guanine Residue and a 3'-alkenal end product in duplex DNA
(University of Missouri--Columbia, 2019) -
Palladium nanoparticles encapsulated with resveratrol-derived phenols and polyphenols for targeted prostate cancer therapy
(University of Missouri--Columbia, 2019)The main goal of this dissertation was to explore the development of a new generation of green nanoformulations through the production of biocompatible palladium nanoparticles using resveratrol to treat, image and evaluate ... -
Evaluation for ammonium bifluoride dissolution for application to post-detonation nuclear forensics and rare Earth element extraction
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] If a nuclear device were to be used in an act of terrorism, prompt nuclear forensic analysis of the post-detonation debris is crucial in order to ... -
Docosahexaenoic acid and lipid peroxidation products : insights from studies with microglial cells and mouse brain
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Oxidative stress is known to play an important role in neurodegenerative diseases. Microglia are the primary innate immune cells in the central nervous ... -
Synthesis and reactivity of low-valent uranium and neptunium complexes
(University of Missouri--Columbia, 2019)Chapter 1 reports the synthesis and characterization of U(IV) and Np(IV) selenium bis(phenolate) complexes. The reaction of the U(IV) complex with half an equivalent of p-benzoquinone results in the formation of a U(V)--U(V) ... -
Technetium and rhenium schiff base complexes for nuclear medicine
(University of Missouri--Columbia, 2019)This dissertation investigates the synthesis of rhenium and technetium Schiff base complexes for potential applications in nuclear medicine. In Chapter 2, a series of mixed ligand Re(III) complexes of the form trans-[Re( ... -
Boron quantitative analysis and imaging analysis in plants
(University of Missouri--Columbia, 2017)Boron is a very important nutrient element in plants, and thus it plays a key role in the world's food supply. Both boron deficiency and boron toxicity will cause plants to decrease their crop yield or even cause plants ... -
Atomic-scale studies of chemical and transport processes relevant to propellant combustion
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Density functional theory (DFT) and correlated molecular orbital electronic structure calculations were used to study the Al + CO2 [subscript arrow] ... -
Novel syntheses and behavior of precious metal nanoparticles
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In this work, I report the detailed syntheses of both gold-doped iron oxide (Au@Fe2O3) and silver nanocrystals (AgNCs). The Au@Fe2O3 was produced ... -
Synthethic pathways to multiple surface functionalization of polyhedral boranes
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The chemistry of dodecahydro--closo--dodecaborate(2-), closo-[B12H12]2-, and decahydro-closo-decaborate(2-), [B10H10]2-, with different organic ... -
Synthesis and preclinical evaluation of peptide receptor-targeted diagnostic and therapeutic radiopharmaceuticals for prostate cancer
(University of Missouri--Columbia, 2019)The overexpression of certain peptide receptors on cancers cells can be exploited for the development of radiopharmaceuticals that are selectively delivered to cancer cells for diagnostic imaging or therapeutic purposes. ... -
Anisotropic shock response of 1,3,5-Triamino-2,4,6-Trinitrobenzene (TATB)
(University of Missouri--Columbia, 2018)All-atom molecular dynamics simulations were used to study shock wave loading in both oriented single crystals and two orientations with the presence of a grain boundary of the highly anisotropic triclinic molecular crystal ... -
DNA interstrand crosslinks arising from DAN strand breaks at true abasic sites in duplex DNA
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Abasic sites (apurinic/apyrimidinic sites, Ap sites) are one of the most common forms of lesions found in genomic DNA. For the past decade, Gates group ... -
Diverse applications of covalent cross-links in duplex DNA: From anti-cancer drugs to the detection of disease-relevant single nucleotide polymorphisms to the synthesis of well-defined substrates for the study of novel DNA repair processes
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Abasic (Ap) sites are a common form of DNA lesion that occur endogenously 50,000-200,000 per cell per day in mammals. The alkylation of the guanine and ... -
The use of pluripotent stem cells as a model for early human placentation
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Throughout gestation, the placenta plays a critical role in ensuring proper development of the fetus. The placenta functions to exchange nutrients, ... -
Arsenic-72, 77 as a matched pair radiopharmaceutical for imaging and radiotherapy
(University of Missouri--Columbia, 2018)Radiopharmaceuticals deliver radionuclides to specific target sites via the bifunctional chelate approach, where the radionuclides are chelated with a ligand and linked to a targeting biomolecule. They can be categorized ... -
Development of radiolabeled metal chalcogenide nanoparticles for targeted adiotherapy against an infection
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Targeted radiotherapy has been demonstrated to be therapeutic against infections with doses comparable to what a patient would receive for cancer ...