RSS 1.0Department of Chemistry (MU)
The Department of Chemistry at the College of Arts and Sciences University of Missouri-Columbia offers Graduate and Undergraduate degree programs and houses multiple research facilities.
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Biomimetic reactions relevant to the study of abasic sites in DNA
(University of Missouri--Columbia, 2020)Abasic (Ap) sites represent the most common form of DNA damage in mammalian cells. With steady state levels of 10,000 sites existing in each cell, there is a dire need to study these noxious biological electrophiles. While ... -
Novel techniques for cold/ultracold molecular collisions
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] This thesis presents the successful implementation of a slice velocity map imaging apparatus capable of performing molecular beam scattering experiments ... -
Theranostic and Matched Pair Radionuclides as Radiopharmaceutical as for Imaging and Radiotherapy
(University of Missouri--Columbia, 2020)The main focus of this dissertation is on the development of arsenic and rhenium radiopharmaceuticals as potential theranostic candidates. Chapter 2 focuses on 72,77. As radiopharmaceuticals for potential PET imaging and ... -
Quantum aspects of roaming dynamics
(University of Missouri--Columbia, 2020)Decades of experimental and theoretical achievements built on the foundations of thermochemistry and quantum mechanics have birthed the field of molecular dynamics where intimate details of individual reactive events can ... -
Stereoselective synthesis of seven-membered rings using intramolecular (4+3) cycloaddition reactions
(University of Missouri--Columbia, 2020)Heterocyclic molecules containing seven-membered rings have importance in organic synthesis owing to their presence in some natural products and biologically active molecules. Furthermore, these scaffolds act as important ... -
Development of selective high-affinity fluorescent sensors for imaging neurotransmitters and application in cells and tissue
(University of Missouri--Columbia, 2019)Herein, we develop a series of selective fluorescent sensors based on a quinolone core designed to image neurotransmitters catecholamines, serotonin and glutamate. Included are the main design strategy, synthesis, spectroscopic ... -
Insights into atomic orbital polarization in polyatomic dissociation from DC slide velocity map imaging
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] "The field of chemical reaction dynamics is based upon understanding the details of elementary chemical reactions. It seeks to answer fundamental ... -
Effects of local sequence on the formation of interstrand DNA cross-links derived from the reaction of an abasic site with a cytosine residue on the opposing strand
(University of Missouri--Columbia, 2019)DNA Interstrand Cross-Links are of special concern due to the difficulty of repair and cytotoxicity of cells associated with these lesions. Interstrand Cross-Links between abasic sites and native nucleobases has shown ... -
Strategies for metal colloidal nancrystal synthesis in sustainable media
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Over the past decades, the Green Chemistry and Sustainability concept has aroused researchers to denounce their traditional ways of thinking regarding ... -
A study of bacterial cellulose confined ionic liquid and deep eutectic solvent gel materials
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Pollutants have become more prevalent in the air, water, and ground, necessitating the development of technologies that would help, limit, ... -
(4+3)-cycloaddition chemists of oxidopyridinium ions and related study
(University of Missouri--Columbia, 2019)The (4+3)-cycloaddition reaction is a cycloaddition between a 4-atom species and a 3-atom species to form a seven-membered ring. This reaction results in the formation of seven-membered rings. Our research expanded the ... -
Investigating reaction conditions for controlling the self-assembly of metal-seamed pyrogallol[4]arene nanocapsules
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Upon coordination to metal ions, C-alkylpyrogallol[4]arenes (PgCn, where n is the number of carbon atoms in the pendant alkyl chains), can be assembled ... -
Structural, biochemical, and inhibition studies of proline biosynthetic enzymes
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of [Delta]1-pyrroli ... -
Novel DNA Adducts- Chemical Reactions that Model the Generation of interstrand cross-links between a Guanine Residue and a 3'-alkenal end product in duplex DNA
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Modification of DNA by chemicals produced lethal biological effects such as carcinogenesis, cytotoxicity, etc. Abasic site (Ap site) can ... -
Palladium nanoparticles encapsulated with resveratrol-derived phenols and polyphenols for targeted prostate cancer therapy
(University of Missouri--Columbia, 2019)The main goal of this dissertation was to explore the development of a new generation of green nanoformulations through the production of biocompatible palladium nanoparticles using resveratrol to treat, image and evaluate ... -
Evaluation for ammonium bifluoride dissolution for application to post-detonation nuclear forensics and rare Earth element extraction
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] If a nuclear device were to be used in an act of terrorism, prompt nuclear forensic analysis of the post-detonation debris is crucial in order to ... -
Docosahexaenoic acid and lipid peroxidation products : insights from studies with microglial cells and mouse brain
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Oxidative stress is known to play an important role in neurodegenerative diseases. Microglia are the primary innate immune cells in the central nervous ... -
Synthesis and reactivity of low-valent uranium and neptunium complexes
(University of Missouri--Columbia, 2019)Chapter 1 reports the synthesis and characterization of U(IV) and Np(IV) selenium bis(phenolate) complexes. The reaction of the U(IV) complex with half an equivalent of p-benzoquinone results in the formation of a U(V)--U(V) ... -
Technetium and rhenium schiff base complexes for nuclear medicine
(University of Missouri--Columbia, 2019)This dissertation investigates the synthesis of rhenium and technetium Schiff base complexes for potential applications in nuclear medicine. In Chapter 2, a series of mixed ligand Re(III) complexes of the form trans-[Re( ... -
Boron quantitative analysis and imaging analysis in plants
(University of Missouri--Columbia, 2017)Boron is a very important nutrient element in plants, and thus it plays a key role in the world's food supply. Both boron deficiency and boron toxicity will cause plants to decrease their crop yield or even cause plants ...