RSS 1.0Department of Chemistry (MU)
The Department of Chemistry at the College of Arts and Sciences University of Missouri-Columbia offers Graduate and Undergraduate degree programs and houses multiple research facilities.
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Evaluation for ammonium bifluoride dissolution for application to post-detonation nuclear forensics and rare Earth element extraction
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] If a nuclear device were to be used in an act of terrorism, prompt nuclear forensic analysis of the post-detonation debris is crucial in order to ... -
Docosahexaenoic acid and lipid peroxidation products : insights from studies with microglial cells and mouse brain
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Oxidative stress is known to play an important role in neurodegenerative diseases. Microglia are the primary innate immune cells in the central nervous ... -
Synthesis and reactivity of low-valent uranium and neptunium complexes
(University of Missouri--Columbia, 2019)Chapter 1 reports the synthesis and characterization of U(IV) and Np(IV) selenium bis(phenolate) complexes. The reaction of the U(IV) complex with half an equivalent of p-benzoquinone results in the formation of a U(V)--U(V) ... -
Technetium and rhenium schiff base complexes for nuclear medicine
(University of Missouri--Columbia, 2019)This dissertation investigates the synthesis of rhenium and technetium Schiff base complexes for potential applications in nuclear medicine. In Chapter 2, a series of mixed ligand Re(III) complexes of the form trans-[Re( ... -
Atomic-scale studies of chemical and transport processes relevant to propellant combustion
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Density functional theory (DFT) and correlated molecular orbital electronic structure calculations were used to study the Al + CO2 [subscript arrow] ... -
Novel syntheses and behavior of precious metal nanoparticles
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In this work, I report the detailed syntheses of both gold-doped iron oxide (Au@Fe2O3) and silver nanocrystals (AgNCs). The Au@Fe2O3 was produced ... -
Synthethic pathways to multiple surface functionalization of polyhedral boranes
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The chemistry of dodecahydro--closo--dodecaborate(2-), closo-[B12H12]2-, and decahydro-closo-decaborate(2-), [B10H10]2-, with different organic ... -
Synthesis and preclinical evaluation of peptide receptor-targeted diagnostic and therapeutic radiopharmaceuticals for prostate cancer
(University of Missouri--Columbia, 2019)The overexpression of certain peptide receptors on cancers cells can be exploited for the development of radiopharmaceuticals that are selectively delivered to cancer cells for diagnostic imaging or therapeutic purposes. ... -
Anisotropic shock response of 1,3,5-Triamino-2,4,6-Trinitrobenzene (TATB)
(University of Missouri--Columbia, 2018)All-atom molecular dynamics simulations were used to study shock wave loading in both oriented single crystals and two orientations with the presence of a grain boundary of the highly anisotropic triclinic molecular crystal ... -
DNA interstrand crosslinks arising from DAN strand breaks at true abasic sites in duplex DNA
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Abasic sites (apurinic/apyrimidinic sites, Ap sites) are one of the most common forms of lesions found in genomic DNA. For the past decade, Gates group ... -
Diverse applications of covalent cross-links in duplex DNA: From anti-cancer drugs to the detection of disease-relevant single nucleotide polymorphisms to the synthesis of well-defined substrates for the study of novel DNA repair processes
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Abasic (Ap) sites are a common form of DNA lesion that occur endogenously 50,000-200,000 per cell per day in mammals. The alkylation of the guanine and ... -
The use of pluripotent stem cells as a model for early human placentation
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Throughout gestation, the placenta plays a critical role in ensuring proper development of the fetus. The placenta functions to exchange nutrients, ... -
Arsenic-72, 77 as a matched pair radiopharmaceutical for imaging and radiotherapy
(University of Missouri--Columbia, 2018)Radiopharmaceuticals deliver radionuclides to specific target sites via the bifunctional chelate approach, where the radionuclides are chelated with a ligand and linked to a targeting biomolecule. They can be categorized ... -
Development of radiolabeled metal chalcogenide nanoparticles for targeted adiotherapy against an infection
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Targeted radiotherapy has been demonstrated to be therapeutic against infections with doses comparable to what a patient would receive for cancer ... -
Studies and synthetic methodology of Nampt inhibition
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The purpose of this research is to study and synthesize an array of a highly potent pharmaceuticals that can selectively cause apoptosis in various ... -
Solvatochromic pyrogallarenes and pyrogallarene crystals
(University of Missouri--Columbia, 2018)Pyrogallarenes have the ability to self-assemble into a variety of structures. Crystal forms ranging from bilayers to dimers and hexamers have been isolated. One unique cocrystal, PgC[subscript 3]-(CH[subscript 3])[subscript ... -
Isotope harvesting from the beam dump cooling loop at the facility for rare isotope beams (FRIB)
(University of Missouri--Columbia, 2018)Isotope harvesting from the beam dump cooling loop of the Facility for Rare Isotope Beams (FRIB) offers usable quantities of many isotopes unavailable anywhere else in the world. Many of these co-produced isotopes are of ... -
Deep eutectic solvents : investigation of solvent structure and its applications
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Deep eutectic solvents (DESs) represent an alternative class of ionic fluids closely resembling room-temperature ionic liquids (RTILs), they are ... -
Synthesis and Reactivity of 1,2-Bis(di-iso-propylphosphino)benzene Nickel Complexes: A Study of Catalytic CO2-Ethylene Coupling [Datasets]
(2018)Single crystal X-ray diffraction photographs and data reduction output files in proprietary format, collected on a Bruker D8 Venture diffractometer with a Photon 100 detector using the Apex3 software suite. -
Structural basis of stability of human immunodeficiency virus type 1 (HIV-1) capsid
(University of Missouri--Columbia, 2017)Human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of acquired immunodeficiency syndrome (AIDS). Since its discovery in early 1980, many advances have been made in the prevention and management of HIV/AIDS. ...