• Amyloid beta induces cPLA2 activation by an NADPH oxidase-dependent mechanism in neurons 

    Shelat, Phullara B., 1978- (University of Missouri--Columbia, 2008)
    Alzheimer's disease (AD) is a neurodegenerative disorder affecting more than 20 million people worldwide. An increase in production of amyloid beta peptides (A[Beta]) and their aggregation to the oligomeric form is thought ...
  • Regulation of Nrf2 by a keap1-dependent E3 ubiquitin ligase 

    Lo, Shih-Ching, 1979- (University of Missouri--Columbia, 2007)
    Oxidative damage to biological macromolecules has been implicated in diverse pathophysiological processes, including cancer, neurodegeneration, aging and cardiovascular disease. The Nrf2 transcription factor regulates ...