• Characterization of PGAM5 

    Wilkins, Jordan, 1983- (University of Missouri--Columbia, 2013)
    Programmed cell death (PCD) is a naturally occurring event that is highly regulated and required for normal development. The protein phosphoglycerate mutase 5 (PGAM5) has been implicated in apoptosis, necrosis, and autophagy ...
  • Crystal structure of the kelch domain of human keap1 

    Li, Xuchu, 1976- (University of Missouri--Columbia, 2005)
    The transcription factor Nrf2 activates transcription of Phase II detoxification genes to combat oxidative stress. Under normal conditions, Nrf2 is located in the cytoplasm and is associated with a BTB-Kelch protein termed ...
  • Regulation of Nrf2 by a keap1-dependent E3 ubiquitin ligase 

    Lo, Shih-Ching, 1979- (University of Missouri--Columbia, 2007)
    Oxidative damage to biological macromolecules has been implicated in diverse pathophysiological processes, including cancer, neurodegeneration, aging and cardiovascular disease. The Nrf2 transcription factor regulates ...