Department of Biochemistry (MU)
Biochemistry at Missouri, part of both the School of Medicine and the College of Agriculture, Food and Natural Resources, is noted for interdisciplinary research and effective instruction. The two are interwoven to provide excellence in both. With our very name, we span biology and chemistry. Essentially all facets of contemporary biochemical research are represented in the department.
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Structural studies of flavoprotein inhibitors and inactivators
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Flavoenzymes have a versatile capacity to catalyze a wide range of reactions, using their flavin cofactor. In this thesis, work on two ... -
Merging technology development of trapped ion mobility spectrometry quadrupole time-of-flight mass spectrometry with biological investigation of Medicago truncatularoot exudates
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] "New commercial ion mobility instrumentation has the potential to improve current analytical techniques, but developments need to be applicable to ... -
Viral RNA structural equilibria and their interactions with host proteins
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI SYSTEM AT REQUEST OF AUTHOR.] Understanding viral RNA structure and how it functions is crucial in elucidating new drug targets. There are many kinds of viruses that utilize ... -
RNA aptamers and HIV reverse transcriptase : molecular basis of their interactions and the evaluation of aptamer resistance
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI SYSTEM AT REQUEST OF AUTHOR.] Human Immunodeficiency virus (HIV) is a pandemic Lentivirus that causes acquired immune deficiency syndrome (AIDS) in infected individuals. One ... -
Biophysical characterization of the structure and flexibility of the E. Coli ribosome
(University of Missouri--Columbia, 2019)At the discovery of ribosomes by George Palade in 1955 in the first image of the subcellular environment, he described them as "a particulate component of small dimensions (100 to 150 [alpha]) and high density". Subsequently, ... -
Development of novel site-specific imaging probes for prostate cancer detection
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Molecular imaging is believed to play a pivotal role in decreasing cancer mortality and improving prognosis in the new era. It relies on molecular ... -
Pretargeted cancer radioimmunotherapy and radioimaging using antibodies and antibody fragments
(University of Missouri--Columbia, 2018)Over the last few decades, antibodies have become the mainstay of cancer diagnosis and therapeutics. In traditional radioimmunotherapy (RIT), tumor targeting antibodies are directly conjugated with radioisotopes and depending ... -
Roles of clathrin-coated vesicle networks in plant immunity and development
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] For a plant cell, the plasma membrane (PM) is not only the interface with its environment but also a signaling platform. Proteins localized ... -
Molecular mechanisms of enzyme dysfunction in human phosphoglucomutase-1 deficiency
(University of Missouri--Columbia, 2019)Human phosphoglucomutase-1 (PGM1) belongs to the [alpha]-D-phosphohexomutase superfamily, an ancient lineage of enzymes critical for carbohydrate metabolism. PGM1 catalyzes the interconversion of glucose-1-phosphate and ... -
Characterization of the effects of 3,3'-diindolylmethane (DIM) in the TRAMP mouse prostate cancer model and DIM's interaction with estrogen receptor signaling
(University of Missouri--Columbia, 2018)3,3'- diindolylmethane (DIM) is an acid -derived compound formed during the digestion of indole-3-carbinol (I3C), which is one of the main compounds in cruciferous vegetables, such as broccoli, cabbage and kale. Studies ... -
A novel role for the ATP7A copper transporter in cancer
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI SYSTEM AT AUTHOR'S REQUEST.] Copper is a trace metal with a ready capacity to gain or donate electrons. This property is harnessed by numerous enzymes to perform vital ... -
Investigating the role of arginine 21 in the structure and function of human [alpha]a-crystallin
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI SYSTEM AT AUTHOR'S REQUEST.] Cataractogenesis in the eye lens occurs as a result of protein aggregation. Of the multiple mutations in [alpha]A-crystallins associated with ... -
Selective modulation of estrogen receptors : 27-hydroxycholesterol is a negative allosteric modulator of er-beta activity and estradiol binding
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] The estrogen receptors alpha (ER[alpha]) and beta (ER[beta]) are important regulators of development and growth in many major organ systems. ... -
Membrane interactions with membrane type 1 matrix metalloproteinase
(University of Missouri--Columbia, 2018)Membrane type 1 matrix metalloproteinase (MT1-MMP) is essential to a myriad of extracellular activities including tumor cell migration and angiogenesis. At the cell surface, MT1-MMP is a major factor in the proteolysis of ... -
Spatial restrictions in chemotaxis signaling arrays: a role for chemoreceptor flexible hinges across bacterial diversity [supporting material]
(2019)Modeling tool available as a Mathematica Computable Document Format (cdf) file that can be downloaded here. It requires installation of the free Wolfram Player [https://www.wolfram.com/player/] or the full Mathematica ... -
Investigating the role of arginine 21 in the structure and function of human [alpha]A-crystallin
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI SYSTEM AT AUTHOR'S REQUEST.] Cataractogenesis in the eye lens occurs as a result of protein aggregation. Of the multiple mutations in [alpha]A-crystallins associated with ... -
Toxicology studies of H. procumbens aqueous-alcohol extracts in female and male rats : dataset
(2019)Raw hematology and pathology data for male and female rats fed H. procumbens Aqueous-Alcohol Extracts from 1-month and 3-month experiments. -
Bacterial ribosome conformational dynamics during translation termination and rescue
(University of Missouri--Columbia, 2017)Hydrolysis of polypeptide from the ribosome is a critical step that must occur prior to the ribosome recycling phase of translation. Inability of cells to do so can result in translation inhibition and eventually leading ... -
Dissecting water stress-induced molecular responses in the maize primary root
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Drought is an important environmental factor limiting crop growth and productivity. With additional pressures arising from population growth and global ... -
Making others happy : the best route to one's own happiness?
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] There are many positive psychology interventions whose aim is to help people improve their levels of happiness and well-being, some of which work ...