Biochemistry electronic theses and dissertations (MU)
The items in this collection are the theses and dissertations written by students of the Division of Biochemistry. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Columbia. Click on one of the browse buttons above for a complete listing of the works.
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Recent Submissions
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Structural studies of flavoprotein inhibitors and inactivators
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Flavoenzymes have a versatile capacity to catalyze a wide range of reactions, using their flavin cofactor. In this thesis, work on two ... -
Merging technology development of trapped ion mobility spectrometry quadrupole time-of-flight mass spectrometry with biological investigation of Medicago truncatularoot exudates
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] "New commercial ion mobility instrumentation has the potential to improve current analytical techniques, but developments need to be applicable to ... -
Viral RNA structural equilibria and their interactions with host proteins
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Understanding viral RNA structure and how it functions is crucial in elucidating new drug targets. There are many kinds of viruses that utilize RNA ... -
RNA aptamers and HIV reverse transcriptase : molecular basis of their interactions and the evaluation of aptamer resistance
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Human Immunodeficiency virus (HIV) is a pandemic Lentivirus that causes acquired immune deficiency syndrome (AIDS) in infected individuals. One of the ... -
Biophysical characterization of the structure and flexibility of the E. Coli ribosome
(University of Missouri--Columbia, 2019)At the discovery of ribosomes by George Palade in 1955 in the first image of the subcellular environment, he described them as "a particulate component of small dimensions (100 to 150 [alpha]) and high density". Subsequently, ... -
Development of novel site-specific imaging probes for prostate cancer detection
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Molecular imaging is believed to play a pivotal role in decreasing cancer mortality and improving prognosis in the new era. It relies on molecular ... -
Pretargeted cancer radioimmunotherapy and radioimaging using antibodies and antibody fragments
(University of Missouri--Columbia, 2018)Over the last few decades, antibodies have become the mainstay of cancer diagnosis and therapeutics. In traditional radioimmunotherapy (RIT), tumor targeting antibodies are directly conjugated with radioisotopes and depending ... -
Roles of clathrin-coated vesicle networks in plant immunity and development
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] For a plant cell, the plasma membrane (PM) is not only the interface with its environment but also a signaling platform. Proteins localized to the PM ... -
Molecular mechanisms of enzyme dysfunction in human phosphoglucomutase-1 deficiency
(University of Missouri--Columbia, 2019)Human phosphoglucomutase-1 (PGM1) belongs to the [alpha]-D-phosphohexomutase superfamily, an ancient lineage of enzymes critical for carbohydrate metabolism. PGM1 catalyzes the interconversion of glucose-1-phosphate and ... -
Characterization of the effects of 3,3'-diindolylmethane (DIM) in the TRAMP mouse prostate cancer model and DIM's interaction with estrogen receptor signaling
(University of Missouri--Columbia, 2018)3,3'- diindolylmethane (DIM) is an acid -derived compound formed during the digestion of indole-3-carbinol (I3C), which is one of the main compounds in cruciferous vegetables, such as broccoli, cabbage and kale. Studies ... -
A novel role for the ATP7A copper transporter in cancer
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is a trace metal with a ready capacity to gain or donate electrons. This property is harnessed by numerous enzymes to perform vital functions ... -
Investigating the role of arginine 21 in the structure and function of human [alpha]a-crystallin
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cataractogenesis in the eye lens occurs as a result of protein aggregation. Of the multiple mutations in [alpha]A-crystallins associated with the ... -
Selective modulation of estrogen receptors : 27-hydroxycholesterol is a negative allosteric modulator of er-beta activity and estradiol binding
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The estrogen receptors alpha (ER[alpha]) and beta (ER[beta]) are important regulators of development and growth in many major organ systems. In the ... -
Membrane interactions with membrane type 1 matrix metalloproteinase
(University of Missouri--Columbia, 2018)Membrane type 1 matrix metalloproteinase (MT1-MMP) is essential to a myriad of extracellular activities including tumor cell migration and angiogenesis. At the cell surface, MT1-MMP is a major factor in the proteolysis of ... -
Investigating the role of arginine 21 in the structure and function of human [alpha]A-crystallin
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cataractogenesis in the eye lens occurs as a result of protein aggregation. Of the multiple mutations in [alpha]A-crystallins associated with the ... -
Bacterial ribosome conformational dynamics during translation termination and rescue
(University of Missouri--Columbia, 2017)Hydrolysis of polypeptide from the ribosome is a critical step that must occur prior to the ribosome recycling phase of translation. Inability of cells to do so can result in translation inhibition and eventually leading ... -
Dissecting water stress-induced molecular responses in the maize primary root
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Drought is an important environmental factor limiting crop growth and productivity. With additional pressures arising from population growth and global ... -
Making others happy : the best route to one's own happiness?
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] There are many positive psychology interventions whose aim is to help people improve their levels of happiness and well-being, some of which work ... -
Targeting estrogen- and hedgehog-signaling pathways in prostate cancer
(University of Missouri--Columbia, 2009)Prostate cancer is the second most frequent cause of cancer deaths in men, and the risk to develop cancer increases with age. Since the lifespan of the society is progressively increasing, the importance of preventing the ... -
Characterizing the roles of an Arabidopsis Epsin n-terminal homology domain protein in plant innate immunity
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The plasma membrane (PM) serves as a crucial point of contact between a plant cell and its environment. Localized at this critical interface are proteins ...