Browsing Chemistry electronic theses and dissertations (MU) by Thesis Semester "2008 Spring"
Now showing items 1-8 of 8
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Biologically relevant chemistry of sulfur heterocycles : from redox regulation of PTP1B to the biological activity of s-deoxy leinamycin
(University of Missouri--Columbia, 2008)Protein tyrosine phosphatase 1B (PTP1B) is an important member of protein tyrosine phosphatase (PTPs) family that shares a conserved catalytic cysteine thiol residue. PTP1B acts as a negative regulator of insulin mediated ... -
Chemical mechanisms underlying the medicinal activity of metabolically-activated N-oxide antitumor agents
(University of Missouri--Columbia, 2008)Tirapazamine (TPZ) belongs to a new class of bio-reductively activated hypoxiaselective anti-cancer agents and is currently undergoing in various clinical trials including Phase I, II and III. Anti-cancer activity of TPZ ... -
Copper (I) coordination networks synthesized with solid-solid reactions
(University of Missouri--Columbia, 2008)The use of solid-solid reactions in the development of one-, two-, and three dimensional Cu(I) coordination networks are discussed. The solid-solid reactions were monitored by a variety of instrumental techniques to achieve ... -
High valent uranium dioxo and imido complexes : synthesis and structure
(University of Missouri--Columbia, 2008)Early actinide elements have attracted considerable attention in recent years due to the need for rigorous advancements in spent nuclear fuel recycling and remediation technologies, and for their emerging versatility in ... -
Oxidative DNA damage by 1-hydroxyphenazine, virulence factor of Pseudomonas aeruginosa : towards a molecular understanding of the bacterial virulence factor 1-hydroxyphenazine
(University of Missouri--Columbia, 2008)1-Hydroxyphenazine is a secondary metabolite and virulence factor of Pseudomonas aeruginosa. This organism colonizes the airways of the patients of cystic fibrosis and causes progressive destruction of the airways. It is ... -
Spectroscopic investigations of acrylodan dye interactions with poly(amidoamine) and poly(propyleneimine) dendrimers
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The novel molecular architecture of dendrimers facilitates use in many applications. Using the solvatochromic probe phenol blue, the first direct ... -
Spectroscopic investigations of dendritic polymers as molecular containers
(University of Missouri--Columbia, 2008)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Previous research has shown the fluorescent probe phenol blue will associate with the dendritic polymers polypropyleneimine (PPI) and polyamidoamine ... -
The synthesis and characterization of 1,1'-disubstituted ferrocene imine Schiff base ligand systems for use as potential environmental heavy metal cationic sensors
(University of Missouri--Columbia, 2008)Heavy metals in the environment such as Cd, Hg and Pb are toxic to life forms. They can enter the ecological system through both natural and industrial sources. By developing chemical sensors that can detect these metals, ...