Browsing Chemistry electronic theses and dissertations (MU) by Thesis Advisor "Tanner, John J., 1961-"
Now showing items 1-8 of 8
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Structural and functional studies of proline catabolic enzymes and human aldehyde dehydrogenases
(University of Missouri--Columbia, 2015)Oxidation of amino acids, like proline catabolism, is a central part of energy metabolism. Proline is oxidized to glutamate by two enzymes: proline dehydrogenase (PRODH) and 1-pyrroline-5-carboxylate dehydrogenase (P5CDH). ... -
Structural and kinetic studies of bifunctional and monofunctional proline catabolic enzymes
(University of Missouri--Columbia, 2011)PutAs, Proline dehydrogenase and P5C dehydrogenase are involved in the oxidation of proline to glutamate. Mutations in proline dehydrogenase and P5C dehydrogenase cause a disease condition known as hyperprolinemia. In this ... -
Structural basis of substrate recognition and inactivation in phosphatases
(University of Missouri--Columbia, 2011)Phosphatases are ubiquitous enzymes that catalyze the transfer of phosphoryl group to water. In addition to being one of the most important and fundamental reactions in biological systems, phosphatases are critical to ... -
Structural characterization of UDP-galactopyranose mutase from eukaryotic pathogens
(University of Missouri--Columbia, 2013)UDP-galactopyranose mutase (UGM) is a unique flavoenzyme that catalyzes the interconversion between UDP-galactopyranose (UDP-Galp) and UDP-galactofuranose (UDP-Galf), without any net transfer of electrons. UGM is a central ... -
Structural diversity of proline catabolic enzymes revealed by small angle x-ray scattering, x-ray crystallography and light scattering
(University of Missouri--Columbia, 2012)The proline catabolic enzymes catalyze the 4-electron oxidation of proline to glutamate. The reaction involves two enzymes, proline dehydrogenase (PRODH) and Δ1-pyrroline -5-carboxylate dehydrogenase (P5CDH). Some bacterial ... -
Structural studies of acid phosphatases from pathogenic bacteria
(University of Missouri--Columbia, 2007)Acid phosphatases are important, ubiquitous, and diverse group of enzymes that catalyze the transfer of phosphoryl from phosphomonoester to water forming inorganic phosphate and alcohol. These enzymes play critical roles ... -
Structural, biochemical, and inhibition studies of proline biosynthetic enzymes
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Pyrroline-5-carboxylate reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of [Delta]1-pyrroli ... -
Understanding substrate binding and movement in proline catabolic enzymes
(University of Missouri--Columbia, 2014)Proline catabolism is the breakdown of proline to glutamate. This is catalyzed by two enzymes that can be either distinct, monofunctional enzymes or fused into one bifunctional enzyme. When the two enzymes are fused together ...