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Structural characterization of UDP-galactopyranose mutase from eukaryotic pathogens
(University of Missouri--Columbia, 2013)
UDP-galactopyranose mutase (UGM) is a unique flavoenzyme that catalyzes the interconversion between UDP-galactopyranose (UDP-Galp) and UDP-galactofuranose (UDP-Galf), without any net transfer of electrons. UGM is a central ...
Utilization of gold containing nanomaterials for targeted radiotherapeutic and diagnostic applications
(University of Missouri--Columbia, 2013)
6520-00/(S Several different investigations are discussed in this dissertation, with the common thread of using gold-containing nanomaterials in nuclear medicine applications. Gold nanoparticles form a non-toxic surface ...
Tan B :a long wavelength fluorogenic probe for thiaminase I activity
(University of Missouri--Columbia, 2013)
Thiamine, known as Vitamin B1, is one of the 9 essential Vitamins of the B-complex. It is water-soluble and involved in many cellular processes, such as in the biosynthesis of neurotransmitter. Thiamine deficiency may cause ...
Closomers at a click : a treatise on the design, synthesis and in vivo MRI of novel click closomers as high performance and efficacious contrast agents
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The advent of Magnetic Resonance Imaging or MRI has truly revolutionized the field of medical diagnostic and imaging. The signal intensity and the ...
Applications of radiotracer in plant biology
(University of Missouri--Columbia, 2013)
A radioactive tracer (radiotracer) is generally defined as a radioactive isotope that is used as a tracer, which can be followed or tracked within a system of interest. The use of radiotracers involves the substitution of ...
Evaluation of human toenail as a non-invasive biomonitoring matrix for assessing human exposure to environmental organic pollutants by optimized sample prep and GCHRMS analysis
(University of Missouri--Columbia, 2013)
Human biomonitoring is an analytical challenge to find environmental organic chemicals of varying polarity, persistency, and potential toxicity in a suitable, ideally non-invasive matrix at ppb levels that are significantly ...
Structure, dynamics, evolution and catalysis of phosphohexomutase from Pseudomonas aeruginosa
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] [alpha]-D phosphohexomutases are ubiquitous in the environment and participate in carbohydrate metabolism by catalyzing an intramolecular phosphoryl ...
Development of a rhodium tetrathioether bombesin analogue and investigation of cyclic and acyclic ligand systems for 105Rh(III)
(University of Missouri--Columbia, 2013)
Rhodium-105 is an attractive nuclide for radiotherapeutic applications due to its nuclear properties (566 keV β-, 319 keV [19%], 306 keV [5%]) and the kinetic stability of Rhodium (III) complexes with soft sulfur donor ...