RSS 1.0Biological Engineering electronic theses and dissertations (MU)
The items in this collection are the theses and dissertations written by students of the Department of Biological Engineering. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Columbia. Click on one of the browse buttons above for a complete listing of the works.
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Imaging structural and mechanical properties of articular cartilage using optical polarization tractography
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Osteoarthritis (OA) is an extremely common joint disease, which affects more than one-third of all adults in the USA. Although the entire joint ... -
Engineering target nanomaterials for stable and efficient delivery of siRNA
(University of Missouri--Columbia, 2019)Lung cancer has the highest cancer-related mortality rate in the United States. The most common form of lung cancer is non-small cell lung cancer (NSCLC) with 80-85% of new diagnoses. Mutations in KRAS is the most prevalent ... -
Design and synthesis of targeted NIR fluorescent nanoparticles for bio-imaging
(University of Missouri--Columbia, 2019)Breast cancer is the second most common cancer, and the chance that a woman will die from breast cancer is 2.6%. One in 8 women develop breast cancer during their lives. Treatment includes various forms of chemotherapy and ... -
Prediction of knee loading in native knee and total knee arthroplasty : a forward dynamics computational study
(University of Missouri--Columbia, 2019)Focus of the Dissertation: The goal of this dissertation is to develop a musculoskeletal model and corroborate model predictions to experimentally measured in vivo knee contact forces, in order to study the biomechanical ... -
The design of fluorescence correlation spectroscopy for single molecule techniques
(University of Missouri--Columbia, 2019)The ribosome is responsible for protein synthesis- a critical process in creating essential proteins for cell survival. Though bulk techniques yield valuable results about the structure of the ribosome, bulk techniques are ... -
Direct from sample phenotypic antibiotic susceptibility testing
(University of Missouri--Columbia, 2018)To transition from broad-spectrum antibiotic therapy to a more effective "targeted" therapy, i.e. in order to determine whether the infecting strain is resistant or susceptible to individual candidate antibiotics, clinicians ... -
Direct-from-sputum rapid phenotypic drug susceptibility test for mycobacteria
(University of Missouri--Columbia, 2018)The spread of multi-drug resistant tuberculosis (MDR-TB) is a leading global public-health challenge. Because not all biological-mechanisms of resistance are known, culture-based (phenotypic) drug-susceptibility testing ... -
Porous silicates for applications in smart water treatment systems and antimicrobial biomedical coatings
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Porous silicates, particularly ordered ones, may find novel and wide-ranging applications in the bioengineering arena in the near future. For instance, ... -
Climate and land use effects on hydrologic processes and water allocation in a primarily rain-fed, agricultural watershed
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] There is a need to raise our understanding of the impact of climate variability and change on hydrologic processes at the watershed scale. This is ... -
Climate change impacts on hydrologic components and occurrence of drought in an agricultural watershed
(University of Missouri--Columbia, 2018)The study on potential acceleration of future hydrologic cycle due to change in precipitation and increase in temperature are essential for managing natural resources and setting policy. The impact of future climate change ... -
Green solvent-enabled biomass conversion for renewable chemicals and lignin upgrading
(University of Missouri--Columbia, 2018)Lignocellulosic biomass, which is mainly composed of cellulose, hemicellulose, and lignin, is a promising feedstock for producing renewable chemicals and fuels. To make lignocellulosic biomass-based refinery (biorefinery) ... -
Methods of imaging articular cartilage under shear
(University of Missouri--Columbia, 2019)Characterizing both the structure of articular cartilage, and its biomechanical properties is key to gaining a full understanding of how the tissue functions. Articular cartilage is an inhomogeneous tissue with a depth ... -
Accurate DNA microsatellite and microRNA detection with a biological nanopore
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Nanopore-based detection has been used in many genetic, epigenetic, proteomic, and bio-mechanism studies. In this report, we introduced two designed ... -
Automatic four-limb IMU gait analysis in the canine DMD model
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Gait analysis is valuable for studying neuromuscular and skeletal diseases. Wearable motion sensors or inertial measurement units (IMUs) possess ... -
Automated detection of amperometric spikes resulting from quantal exocytosis and estimation of spike and pre-spike foot signal parameters
(University of Missouri--Columbia, 2018)Electrochemical microelectrodes can detect single-vesicle release events as "spikes" of amperometric current. We developed a template based "matched-filter" approach that performs least squares fit of a library of templates ... -
Evaluation of a solid-liquid manure separation operation
(University of Missouri--Columbia, 2018)Field monitoring and laboratory tests were conducted to evaluate the efficacy and practicality of a solid-liquid separation barn for finishing pigs. The solid-liquid separation system included a mechanical scraper and ... -
A continuous-wave-based acoustic method to measure viscoelastic properties of materials
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Typical viscoelastic materials do not have a flat frequency response to mechanical vibrations. Viscoelastic property evaluations with a multi-frequency ... -
Clinical translation of nanomaterials for early detection of genetic abnormalities in fetus and retinopathy in neonates and adults
(University of Missouri--Columbia, 2017)Nuclear medicine covers a wide variety of radionuclides to meet demands of disease. In the current study, first we have looked at the application of mono-amine mono-amide ligands for Re(V), 99mTc(V), and 186Re(V) with ... -
Single nucleotide polymorphism (SNP) discriminations by nanopore sensing
(University of Missouri--Columbia, 2018)Single Nucleotide Polymorphisms (SNPs) are a common type of nucleotide alterations across the genome. A rapid but accurate detection of individual or SNP panels can lead to the right and in-time treatments which possibly ... -
Design and characterization of a hand-held, waveguide-mediated, optoacoustic imaging probe for analyzing burn wounds
(University of Missouri--Columbia, 2018)Clinicians correctly diagnose only [about]66% of burn wounds, which may be in part due to the qualitative methods commonly employed for burn assessment. This often results in over diagnoses, which may lead to unnecessary ...