Browsing Biological Engineering electronic theses and dissertations - Engineering (MU) by Thesis Advisor "Hwang, Tzyh-Chang"
Now showing items 1-3 of 3
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CFTR chloride channels and ABC active transporters undergo similar structural rearrangements as part of their operation
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Defects in the cystic fibrosis transmembrane conductance regulator (CFTR) underlie the lethal genetic disease cystic fibrosis. Although CFTR belongs ... -
Gating of CFTR chloride channels : distinct closed states revealed by the action of AMP-PNP
(University of Missouri--Columbia, 2006)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The CFTR chloride channel is gated by ATP through an irreversible gating cycle driven by an input of free energy of ATP hydrolysis. The open state of ... -
Structure/function studies of CFTR's pore-forming domain reveal evolutionary divergence between CFTR and ABC transporters
(University of Missouri--Columbia, 2015)Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is the culprit behind Cystic Fibrosis (CF), a genetic disease highly occurs among Caucasians. Studying the structure/function of CFTR chloride channel not only ...