• Alternative RNA processing and strategies to modulate splicing 

    Lorson, Christian (Christian Lawrence), 1969- (University of Missouri--Columbia, 2008)
    Spinal Muscular Atrophy (SMA) is a genetic disease that is intrinsically linked to an alternative RNA splicing event that leads a defective protein. To better understand how aberrant RNA processing events occur and lead ...
  • Hormonal regulation of innate immune responses and toll-like receptors in the human endometrium 

    Lange, Margaret J., 1981- (University of Missouri--Columbia, 2008)
    This study examines the role of the steroid hormones, estrogen (E2) and progesterone (P4) in the regulation of TLR3-mediated mucosal immune responses in the human reproductive tract. TLR3 expression in endometrial epithelium ...
  • Immunotherapy for autoimmune diabetes 

    Jain, Renu, 1979- (University of Missouri--Columbia, 2008)
    Type I diabetes (TID) is an autoimmune disorder wherein the insulin producing beta (Beta) cells of the pancreatic islets of Langerhans are destroyed specifically by the [Beta]-cell antigen specific T cells. Numerous ...
  • Microbial pathogen contamination in mouse gametes and embryos 

    Zhang, Lin, 1974 Dec. 4- (University of Missouri--Columbia, 2008)
    Large numbers of transgenic and knockout mice have been generated. Cryopreservation provides an efficient and effective way to maintain these unique genetically modified rodent lines. However, there is a great risk of ...
  • Two aspects of peripheral immune tolerance: systemic and mucosal tolerance mechanisms 

    Divekar, Rohit Dilip, 1978- (University of Missouri--Columbia, 2008)
    Autoimmune diseases are a significant cause of human morbidity and mortality. The defects in immune system that lead to the pathogenesis of autoimmune disease have not been entirely characterized. Autoimmunity develops ...