Department of Molecular Microbiology and Immunology (MU): Recent submissions
Now showing items 1-20 of 136
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Microbiological and electrophoretic studies of the binding of antibiotics by milk and milk components
(University of Missouri--Columbia, 1970)"The most common form of mastitis is associated with the growth and multiplication of bacteria in the milk secreting tissues of the udder. The infected gland reacts to microbial invasion and the host defense mechanism may ... -
A role played by sex in innate immune memory and disease severity
(University of Missouri--Columbia, 2023)While immunological memory has traditionally been understood to be solely within the purview of adaptive immunity, recent evidence has shown that a type of "memory" exists in innate immune cells, as a prior insult can lead ... -
Interplay of Bacillus anthracis spore proteins in the assembly process of the exosporium
(University of Missouri--Columbia, 2023)Spores are the infectious form of the zoonotic pathogen, Bacillus anthracis. The outermost layer of these spores is the exosporium. It consists of a basal layer (major structural proteins are ExsY, CotY, BxpB, and ExsFB) ... -
Yeast mutants containing elevated methionine
(University of Missouri--Columbia, 1983)Yeasts are deficient in methionine which restricts the nutritive value of the protein. The objective of this research was to produce a methionine-rich mutant. Mutants of Candida tropical is ATCC 1369, Candida tropica!is ... -
Synergistic inactivation of Escherichia coli and phage T7 by near-ultraviolet radiation and hydrogen peroxide
(University of Missouri--Columbia, 1979)A non-1ethal concentration of H2O2 enhances NUV inactivation of Escherichia coli and its phages. Three distinct types of synergistic interaction were identified. Conditions were established which allowed the specific ... -
L-tryptophan photoproduct : effect on DNA replication and DNA repair in Escherichia coli
(University of Missouri--Columbia, 1974)"This study was stimulated by two important discoveries. The first of these came to a focus when it was observed that recombinationless (rec) mutants of bacteria were readily killed by near-UV irradiation. Recognition of ... -
Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] The main aim of this dissertation was to display novel immunological ligands, Thrombomodulin (TM) and CD47, on the surface of islets to promote islet engraftment by controlling thrombotic/inflammatory ... -
The multiple roles of FzlA during cell division and stress responses in Agrobacterium tumefaciens
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Disruption of the complex and dynamic process of bacterial cell division results in cellular changes to protect the cells from lysis. In the plant pathogen Agrobacterium tumefaciens, absence of ... -
Persistence of plague : determining which environmental factors contribute to maintenance of Yersinia pestis within sylvatic cycles
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Plague is a prioritized zoonotic disease caused by Yersinia pestis, a gram-negative bacterium. Sylvatic cycles of rodent host and flea vectors have established endemic foci responsible for the ... -
Proposed characterization of POSH function in human T-cell Acute Lymphoblastic Leukemia
(University of Missouri--Columbia, 2023)T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive malignancy that is characterized by leukemic T-cells that can express reduced T-cell markers (such as CD5, CD4, or CD8) reflecting their transformation from an ... -
Mechanisms of inflammation resolution in a murine model of Lyme arthritis
(University of Missouri--Columbia, 2023)In some patients, Lyme arthritis persists despite antibiotic clearance of Borrelia burgdorferi, indicating an underlying defect in inflammation resolution mechanisms. In the murine model of Lyme arthritis (mLA), B. burgdorferi ... -
Evaluation of calcium handling and dwarf open reading frame AAV gene therapy in Duchenne muscular dystrophy
(University of Missouri--Columbia, 2022)Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease. Increased concentrations of cytosolic calcium in dystrophic muscle cells has been implicated in DMD pathogenesis. In healthy muscle, calcium from ... -
Understanding the role of Coxiella outer membrane protein-1 in relation to the Type IVB Secretion system of Coxiella burnetii
(University of Missouri--Columbia, 2022)Obligate intracellular bacterial pathogens, like Coxiella burnetii, the causative agent of Q Fever, rely upon the host for metabolites and carbon sources for energy and biosynthesis of nucleic acids, proteins, and energy ... -
Understanding the insect immune responses to Yersinia pestis using Drosophila melanogaster
(University of Missouri--Columbia, 2022)Yersinia pestis, the causative agent of plague, continues to be transmitted in many different continents, most often by fleas. Despite knowing for a century that Y. pestis can form a biofilm on the flea's proventriculus ... -
Maintenance of relational bindings: working memory or long-term memory?
(University of Missouri--Columbia, 2022)While there has been a wealth of research examining the effects of feature binding in working memory (WM), it remains unclear how relational bindings (pairings of items, or of an item to its presented serial position) are ... -
Yersinia pestis YopJ and its impact on innate immunity
(University of Missouri--Columbia, 2022)Yersinia pestis is one of the most virulent pathogens known to man, with the most impactful epidemics in human history. As the causative agent for the plague, Y. pestis has demonstrated its propensity to ravage through ... -
Influenza virus strategies to regulate S1P-metabolizing enzymes and evade host innate immunity for robust viral replication
(University of Missouri--Columbia, 2021)Viral infection is a complex network of interactions involving the host defending itself against the virus and the virus attempting to subdue host defenses and utilize the cellular machinery to promote its replication. ... -
Refinement of an established large-animal model to understand the tick-pathogen-host interface
(University of Missouri--Columbia, 2021)Ticks are globally distributed vectors of important pathogens of human and animal health. Since the discovery of tick resistance in 1918, the field has sought continuously for the development of effective biologic control ... -
Inhibition and comprehensive analysis of hiv-1 vpu, examination of retroviral trafficking, and characterization of sars-cov-2 genetic material in wastewater
(University of Missouri--Columbia, 2021)Both HIV-1 and SARS-CoV-2 have been responsible for millions of infectionrelated deaths. Despite advances in treatment for both viruses, neither has a cure, and those living with the disease can unknowingly spread the ... -
Novel mouse models for spinal muscular atrophy with respiratory distress type I : characterizing disease relevant models and evaluating therapeutic potential
(University of Missouri--Columbia, 2021)Spinal muscular atrophy with respiratory distress type I (SMARD1) is a rare neurodegenerative disease caused by loss-of-function mutations in the immunoglobulin µ-DNA binding protein 2 (IGHMBP2). SMARD1 is defined by severe ...