RSS 1.0Molecular Microbiology and Immunology electronic theses and dissertations (MU)
The items in this collection are the theses and dissertations written by students of the Department of Molecular Microbiology and Immunology. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Columbia. Click on one of the browse buttons above for a complete listing of the works.
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Recent Submissions
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Structural inferences for reverse transcribing viruses and drug resistance
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] As we narrowly focus on the fundamental questions of our respective systems it is important to interact with the broader scientific community to gain ... -
Reparative dysfunction during muscle regeneration in Duchenne muscular dystrophy: therapeutic approaches to modulating the muscle environment and muscle stem cells
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Duchenne muscular dystrophy (DMD) is a lethal muscular dystrophy resulting from functional loss of the dystrophin protein, a critical sub-sarcolemmal ... -
Analysis of factors that affect pseudotyping in retroviruses
(University of Missouri--Columbia, 2019)Retroviral vectors can efficiently pseudotype with various envelope glycoproteins; however, the molecular mechanism of glycoprotein acquisition process is not completely understood even with their native Env proteins. ... -
The role of apoptosis during inflammation resolution in Lyme arthritis
(University of Missouri--Columbia, 2019)Experimental Lyme arthritis is induced by the infection of C3H mice with the spirochete, Borrelia burgdorferi, and is a valuable model to study the regulation of inflammation during bacterial infection. While the lab has ... -
Vaccine-induced protective immunity against coxiella burnetii
(University of Missouri--Columbia, 2019)Coxiella burnetii is an obligate intracellular Gram-negative bacterial pathogen and the causative agent of human Q fever. This disease presents acutely as a flu-like illness, although it can escalate to a chronic and often ... -
Novel protective modifiers in mouse models of spinal muscular atrophy
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by the homozygous deletion or mutation in the survival motor neuron-1 (SMN1) gene ... -
Labeling HIV-1 nucleic acids during infection and effect of MOV10 in HBV replication
(University of Missouri--Columbia, 2018)Technical limitations in simultaneous microscopic visualization of RNA, DNA, and proteins of HIV have curtailed progress in this field. To address this need we have developed a microscopy approach, multiplex immunofluorescent ... -
Regeneration of insulin-producing [beta]-cells during recovery from disease: a cure for Type 1 Diabetes
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Type 1 diabetes (T1D) is a chronic disease condition characterized by destruction of the insulin-producing [beta]-cells by self-reactive lymphocytes ... -
Mechanisms of clostridial toxin binding and translocation
(University of Missouri--Columbia, 2018)The bacterial genus Clostridium consists of over 150 species of anaerobic, fermentative, spore-forming bacilli. Clostridial species produce up to 20% of all known bacterial exotoxins, which serve as important virulence ... -
Mechanisms of immunity and inflammation in Brucella-induced arthritis
(University of Missouri--Columbia, 2018)"Treatment of unresolved sterile arthritis such as rheumatoid arthritis or osteoarthritis involves eliminating or dampening host inflammatory responses. While inflammation may inflict severe articular pathology to the host ... -
Duchenne muscular dystrophy gene therapy in the canine model
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Duchenne muscular dystrophy (DMD) is a devastating muscle wasting disease caused by loss of function mutations in the dystrophin gene, resulting in the ... -
Unraveling the role of the endogenous complex gut microbiota in the Pirc rat model of human colon cancer
(University of Missouri--Columbia, 2018)The gut microbiota (GM) has recently been shown to modulate several systemic conditions in human and model systems, most importantly in intestinal disorders. It has also been demonstrated to have significant impacts on ... -
Elucidating the mechanisms and dynamics of drug-mediated inhibition and latency reversal in HIV-1 (HIV-1)
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The Human Immunodeficiency Virus Type-1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome, a disease that causes the host to succumb ... -
Protection from pneumonic plague by the induction of heme oxygenase-1
(University of Missouri--Columbia, 2018)Yersinia pestis is the etiological agent of the disease known as plague. The pathology of this disease is characterized by organ failure due to necrosis and hyperinflammation towards the end of the disease. However, Y. ... -
Contribution of the immune system and astrocytes to spinal muscular atrophy pathology
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease and the leading genetic cause of infant mortality. SMA is caused by ... -
Interferon regulatory factor 1 (IRF-1) directs IL-4/IL-13 induced death of neonatal Th1 cells
(University of Missouri--Columbia, 2017)Newborns typically have immune responses that are allergic, due to a predominance of Th2 cells, and lack the ability to respond to vaccines as well as display poor protection against microbes, due to a lack of Th1 cells. ... -
Therapeutic targets for spinal muscular atrophy : Inhibiting the inhibitors
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Spinal muscular atrophy (SMA) is an autosomal recessive disorder that is a leading genetic cause of infantile death. SMA is the most common inherited ... -
The role of sphingosine 1-phosphatemetabolizing enzymes in host defense to RNA virus infections
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Viruses are intracellular parasites that rely on the host cell machinery to effectively replicate themselves and spread within the host to cause ... -
Biochemical characterization of clade B and non-B HIV-1 reverse transcriptase
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Two classes of drugs: nucleos(t)ide reverse transcriptase inhibitors (NRTIs) and non-nucleoside RT inhibitors (NNRTIs) target HIV-1 RT, an enzyme ... -
The parvovirus minute virus of mice modulates the DNA damage response to facilitate viral replication and a pre-mitotic cell cycle block
(University of Missouri--Columbia, 2017)The DNA damage response (DDR) is a critical cellular network that affords cells the ability to repair DNA damage they have incurred from endogenous and exogenous sources. Recently, it has become appreciated that viruses, ...