RSS 1.0Molecular Microbiology and Immunology electronic theses and dissertations (MU)
The items in this collection are the theses and dissertations written by students of the Department of Molecular Microbiology and Immunology. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Columbia. Click on one of the browse buttons above for a complete listing of the works.
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Recent Submissions
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Mechanisms of clostridial toxin binding and translocation
(University of Missouri--Columbia, 2018)The bacterial genus Clostridium consists of over 150 species of anaerobic, fermentative, spore-forming bacilli. Clostridial species produce up to 20% of all known bacterial exotoxins, which serve as important virulence ... -
Mechanisms of immunity and inflammation in Brucella-induced arthritis
(University of Missouri--Columbia, 2018)"Treatment of unresolved sterile arthritis such as rheumatoid arthritis or osteoarthritis involves eliminating or dampening host inflammatory responses. While inflammation may inflict severe articular pathology to the host ... -
Duchenne muscular dystrophy gene therapy in the canine model
(University of Missouri--Columbia, 2018)Duchenne muscular dystrophy (DMD) is a devastating muscle wasting disease caused by loss of function mutations in the dystrophin gene, resulting in the absence of dystrophin, a structural protein in muscle. DMD is the most ... -
Unraveling the role of the endogenous complex gut microbiota in the Pirc rat model of human colon cancer
(University of Missouri--Columbia, 2018)The gut microbiota (GM) has recently been shown to modulate several systemic conditions in human and model systems, most importantly in intestinal disorders. It has also been demonstrated to have significant impacts on ... -
Elucidating the mechanisms and dynamics of drug-mediated inhibition and latency reversal in HIV-1 (HIV-1)
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The Human Immunodeficiency Virus Type-1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome, a disease that causes the host to succumb ... -
Protection from pneumonic plague by the induction of heme oxygenase-1
(University of Missouri--Columbia, 2018)Yersinia pestis is the etiological agent of the disease known as plague. The pathology of this disease is characterized by organ failure due to necrosis and hyperinflammation towards the end of the disease. However, Y. ... -
Contribution of the immune system and astrocytes to spinal muscular atrophy pathology
(University of Missouri--Columbia, 2018)Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease and the leading genetic cause of infant mortality. SMA is caused by afunctional loss of the survival motor neuron-1 (SMN1) gene and the subsequent ... -
Interferon regulatory factor 1 (IRF-1) directs IL-4/IL-13 induced death of neonatal Th1 cells
(University of Missouri--Columbia, 2017)Newborns typically have immune responses that are allergic, due to a predominance of Th2 cells, and lack the ability to respond to vaccines as well as display poor protection against microbes, due to a lack of Th1 cells. ... -
Therapeutic targets for spinal muscular atrophy : Inhibiting the inhibitors
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Spinal muscular atrophy (SMA) is an autosomal recessive disorder that is a leading genetic cause of infantile death. SMA is the most common inherited ... -
The role of sphingosine 1-phosphatemetabolizing enzymes in host defense to RNA virus infections
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Viruses are intracellular parasites that rely on the host cell machinery to effectively replicate themselves and spread within the host to cause ... -
Biochemical characterization of clade B and non-B HIV-1 reverse transcriptase
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Two classes of drugs: nucleos(t)ide reverse transcriptase inhibitors (NRTIs) and non-nucleoside RT inhibitors (NNRTIs) target HIV-1 RT, an enzyme ... -
The parvovirus minute virus of mice modulates the DNA damage response to facilitate viral replication and a pre-mitotic cell cycle block
(University of Missouri--Columbia, 2017)The DNA damage response (DDR) is a critical cellular network that affords cells the ability to repair DNA damage they have incurred from endogenous and exogenous sources. Recently, it has become appreciated that viruses, ... -
Mechanisms of clostridial neurotoxin binding and entry
([University of Missouri--Columbia], 2016)The botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) make up the clostridial neurotoxin (CNT) family. The CNTs are produced by Clostridium botulinum and Clostridum tetani respectively, and are the most potent ... -
Mechanisms of action and efficacy of HCV direct-acting antiviral agents and the host-targeting agent Cyclosporin A
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] -
Mechanisms of cooperation between antigenic and cytokine signals in CD8 T cell activation
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Our adaptive immune system is comprised of white-blood cells that distinguish self- (our own) from foreignproteins (DNA products) and are capable of ... -
Activation and evasion of innate immune signaling pathways by Yersinia pestis
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Yersinia pestis is a bacterial pathogen that causes the disease plague in mammals. The disease is rapidly lethal and infected individuals can succumb ... -
Delineation of Duchenne muscular dystrophy gene therapy using genetically engineered mice
(University of Missouri--Columbia, 2016)Duchenne muscular dystrophy (DMD) is a genetically inherited debilitating muscle disorder affecting young boys due to the loss of dystrophin protein in muscle and the heart. Affected individuals lose their mobility and ... -
Cell-to-cell infection, cell-cell fusion and production of ebolavirus : mechanisms of action and cellular modulators
(University of Missouri--Columbia, 2016)Ebolavirus (EBOV), a member of the Filoviridae family, is a deadly non-segment negative-sense RNA virus that causes hemorrhagic fever among human and other species; the fatality rate can be up to 80%. In 2014, a re-emergent ... -
The cellular and humoral immune response against primary infection with Coxiella burnetii
(University of Missouri--Columbia, 2016)Coxiella burnetii infection in mice results in a limited febrile illness that can be measured by examining splenomegaly, bacterial burden, and histopathology. In humans, this disease is known as Q fever. Using the mouse ... -
Structural and functional characterization of Clostridium difficile toxin B binding and entry
(University of Missouri--Columbia, 2016)Clostridium difficile (C. difficile) has recently emerged as a worldwide nosocomial and iatrogenic infection. C. difficile is a gram-positive, motile bacillus whose sporulation ability significantly contributes to its ...