RSS 1.0Molecular Microbiology and Immunology electronic theses and dissertations (MU)
The items in this collection are the theses and dissertations written by students of the Department of Molecular Microbiology and Immunology. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Columbia. Click on one of the browse buttons above for a complete listing of the works.
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Probing the viral replication of HCV and XMRV: biochemical characterization, inhibition kinetics and role of host proteins in viral replication
(University of Missouri--Columbia, 2015)The studies described in this thesis focus on RNA viruses XMRV and HCV. In Chapter II we focused on Xenotropic Murine leukemia-Related Virus (XMRV). We characterized the biochemical activity and kinetics of the XMRV reverse ... -
The scaffold protein POSH regulates T lymphocyte function
(University of Missouri--Columbia, 2015)T lymphocytes are critical mediators of the adaptive immune response. T cell receptor (TCR) mediated cJUN NH2-terminal kinase (JNK) activation is required for mounting proper T cell mediated immune responses. However, ... -
Posttranscriptional gene regulation of CD4+ T cell cytokine expression by the RNA binding protein HuR
(University of Missouri--Columbia, 2015)Posttranscriptional gene regulation by RNA-binding proteins such as HuR fine tunes gene expression in T cells leading to powerful effects on immune responses. HuR can stabilize target mRNAs and/or promote translation by ... -
Exploring modifiers in spinal muscular atrophy : the power of AAV9
(University of Missouri--Columbia, 2014) -
Investigation of antiviral strategies targeting Human Immunodeficiency Virus Type I (HIV-1)
(University of Missouri--Columbia, 2014)HIV-1 infection is currently treated with antiretroviral therapy. Three antiviral approaches were investigated to gain understanding on how HIV-1 can be tackled: (1) by KD-247, a neutralizing antibody targeting the third ... -
The Cellular Immune Response to Murine Lyme borreliosis
(University of Missouri--Columbia, 2015)Lyme disease is caused by the bacterial spirochete Borrelia burgdorferi. There are approximately 300,000 new cases of Lyme Disease reported in the United States each year. Individuals with Lyme disease often suffer from ... -
Role of T Cell Receptor Signaling in CD8 T Cell Memory
(University of Missouri--Columbia, 2015)The generation of immunological memory is the basis for vaccination. The development of memory CD8 T cells is required for long-term protection against intracellular pathogens, such as viruses, and tumors. While the ... -
Development of genome-wide genetic assays in Desulfovibrio vulgaris Hildenborough
(University of Missouri--Columbia, 2015)Illumina sequencing and other massively-parallel, short read sequencing technologies have become prevalent methods for querying the genetic systems of organisms. This trend was initially driven by the demand for general ... -
Alternative translation and alternative RNA processing mechanism in parvovirus RNA processing
(University of Missouri--Columbia, 2014) -
Gene therapy in mouse models of spinal muscular atrophy :
(University of Missouri--Columbia, 2013)Spinal Muscular Atrophy (SMA), an autosomal recessive neuromuscular disorder, is the leading genetic cause of infant mortality. SMA is caused by the functional, homozygous loss of the Survival Motor Neuron-1 (SMN1) gene ... -
The role of sphingosine kinase in influenza virus mediated inflammasome activitation
(University of Missouri--Columbia, 2013)Influenza viruses continue to pose a grave burden on the global health and economy. Dysregulated innate immune system can lead to rapid infiltration of immune cells to the lungs followed by a cytokine storm, which contributes ... -
On the role of IL-13R[alpha]1 on basophils, dendritic cells and macrophages in neonatal and adult immune systems modulation
(University of Missouri--Columbia, 2013)IL-13R[alpha]1 is a component of the heterodimeric receptor complex formed by IL-4R[alpha] and IL-13R[alpha]1. The receptor is mainly expressed on cells derived from myeloid progenitors such as macrophage and dendritic ... -
Within and beyond immunomodulatory strategies against autoimmune diabetes : antigen-specific tolerance and endothelial regeneration
(University of Missouri--Columbia, 2013)Type 1 diabetes (T1D) is a chronic disorder in which the cells of the immune system mediate selective destruction of the insulin-producing [beta]-cells in the islets of Langerhans in the pancreas. CD4+ effector T cells, ... -
Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity
(University of Missouri--Columbia, 2013)Retroviral compatibility with diverse glycoproteins has been known and identified through the course of several studies. However, molecular mechanisms of glycoprotein acquisition are poorly defined. Glycoproteins are ... -
Sequence and secondary structural analysis of a novel class of RNA aptamers that inhibit reverse transcriptase
(University of Missouri--Columbia, 2012)RNA aptamers are synthetic RNAs selected for their ability to bind a molecular target. Reverse Transcriptase (RT) is the major target of antiretroviral therapy used in the treatment of HIV. RNA aptamers were selected to ... -
On the role of cytokines and route of antigen delivery on the modulation of experimental autoimmune encephalomyelitis
(University of Missouri--Columbia, 2012)Experimental autoimmune encephalomyelitis (EAE) is a mouse model of the human autoimmune disease multiple sclerosis and is caused by myelin-reactive T lymphocytes that recognize antigens embedded within the myelin sheath ... -
Identification and characterization of Boone Cardiovirus, a novel virus of laboratory rats
(University of Missouri--Columbia, 2012)Cardioviruses are members of the Picornaviridae family capable of causing several forms of disease including myocarditis, encephalitis, diabetes, fetal death, and neuron degeneration. A wide range of hosts are susceptible ... -
First contact :
(University of Missouri--Columbia, 2013)The innate immune system must react to a wide variety of foreign stimuli, only a relatively small proportion of which may be classified as harmful. The goal of this thesis was to investigate interactions between macrophages ... -
Mechanisms of inhibition and resistance to antiviral drugs targeting human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV)
(University of Missouri--Columbia, 2012)Although human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV) are very different viruses, the replication of their genome involves a reverse transcription process catalyzed by the viral reverse transcriptase ... -
Mechanistic inhibition studies of SARS-CoV replication and entry
(University of Missouri--Columbia, 2012)Severe acute respiratory syndrome (SARS) is an infectious and highly contagious disease that is caused by SARS-associated coronavirus, (SARS-CoV) and for which there are currently no approved treatments. The non-structural ...