Browsing Molecular Microbiology and Immunology electronic theses and dissertations (MU) by Thesis Department "Molecular microbiology and immunology (MU)"
Now showing items 21-40 of 41
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Labeling HIV-1 nucleic acids during infection and effect of MOV10 in HBV replication
(University of Missouri--Columbia, 2018)Technical limitations in simultaneous microscopic visualization of RNA, DNA, and proteins of HIV have curtailed progress in this field. To address this need we have developed a microscopy approach, multiplex immunofluorescent ... -
Mechanisms of central and peripheral immune tolerance
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The decision of a stem cell to develop into the myeloid or lymphoid lineage has been postulated to occur in the bone marrow. However, a marker of ... -
Mechanisms of clostridial toxin binding and translocation
(University of Missouri--Columbia, 2018)The bacterial genus Clostridium consists of over 150 species of anaerobic, fermentative, spore-forming bacilli. Clostridial species produce up to 20% of all known bacterial exotoxins, which serve as important virulence ... -
Mechanisms of immunity and inflammation in Brucella-induced arthritis
(University of Missouri--Columbia, 2018)"Treatment of unresolved sterile arthritis such as rheumatoid arthritis or osteoarthritis involves eliminating or dampening host inflammatory responses. While inflammation may inflict severe articular pathology to the host ... -
Novel mouse models for spinal muscular atrophy with respiratory distress type I : characterizing disease relevant models and evaluating therapeutic potential
(University of Missouri--Columbia, 2021)Spinal muscular atrophy with respiratory distress type I (SMARD1) is a rare neurodegenerative disease caused by loss-of-function mutations in the immunoglobulin µ-DNA binding protein 2 (IGHMBP2). SMARD1 is defined by severe ... -
Novel protective modifiers in mouse models of spinal muscular atrophy
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by the homozygous deletion or mutation in the survival motor neuron-1 (SMN1) gene ... -
On the role of cytokines and route of antigen delivery on the modulation of experimental autoimmune encephalomyelitis
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Experimental autoimmune encephalomyelitis (EAE) is a mouse model of the human autoimmune disease multiple sclerosis and is caused by myelin-reactive T ... -
Protection from pneumonic plague by the induction of heme oxygenase-1
(University of Missouri--Columbia, 2018)Yersinia pestis is the etiological agent of the disease known as plague. The pathology of this disease is characterized by organ failure due to necrosis and hyperinflammation towards the end of the disease. However, Y. ... -
Protein processing strategies by adeno-associated virus type 5 (AAV5) and the effects of the adenovirus E4orf6/E1b-55k/Cullin 5 E3 ubiquitin ligase complex on AAV protein stability
(University of Missouri--Columbia, 2008)We report the initial identification of the ubiquitination of a parvovirus non-structural protein by the adenovirus E4orf6/E1b-55k/Cullin 5 E3 ubiquitin ligase complex. The small Rep and capsid proteins of adeno-associated ... -
Refinement of an established large-animal model to understand the tick-pathogen-host interface
(University of Missouri--Columbia, 2021)Ticks are globally distributed vectors of important pathogens of human and animal health. Since the discovery of tick resistance in 1918, the field has sought continuously for the development of effective biologic control ... -
Regeneration of insulin-producing [beta]-cells during recovery from disease: a cure for Type 1 Diabetes
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Type 1 diabetes (T1D) is a chronic disease condition characterized by destruction of the insulin-producing [beta]-cells by self-reactive lymphocytes ... -
Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae
(University of Missouri--Columbia, 2010)GLC7 is an essential gene in Saccharomyces cerevisiae that encodes the catalytic subunit of protein phosphatase-1. Glc7 is conditionally activated by phospho-Glc8, which is phosphorylated by the cyclin dependent kinase, ... -
Reparative dysfunction during muscle regeneration in Duchenne muscular dystrophy: therapeutic approaches to modulating the muscle environment and muscle stem cells
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Duchenne muscular dystrophy (DMD) is a lethal muscular dystrophy resulting from functional loss of the dystrophin protein, a critical sub-sarcolemmal ... -
The role of apoptosis during inflammation resolution in Lyme arthritis
(University of Missouri--Columbia, 2019)Experimental Lyme arthritis is induced by the infection of C3H mice with the spirochete, Borrelia burgdorferi, and is a valuable model to study the regulation of inflammation during bacterial infection. While the lab has ... -
The role of sphingosine 1-phosphatemetabolizing enzymes in host defense to RNA virus infections
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Viruses are intracellular parasites that rely on the host cell machinery to effectively replicate themselves and spread within the host to cause ... -
Sequence and secondary structural analysis of a novel class of RNA aptamers that inhibit reverse transcriptase
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] RNA aptamers are synthetic RNAs selected for their ability to bind a molecular target. Reverse Transcriptase (RT) is the major target of antiretroviral ... -
Structural inferences for reverse transcribing viruses and drug resistance
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] As we narrowly focus on the fundamental questions of our respective systems it is important to interact with the broader scientific community to gain ... -
Unraveling the role of the endogenous complex gut microbiota in the Pirc rat model of human colon cancer
(University of Missouri--Columbia, 2018)The gut microbiota (GM) has recently been shown to modulate several systemic conditions in human and model systems, most importantly in intestinal disorders. It has also been demonstrated to have significant impacts on ... -
Vaccine-induced protective immunity against coxiella burnetii
(University of Missouri--Columbia, 2019)Coxiella burnetii is an obligate intracellular Gram-negative bacterial pathogen and the causative agent of human Q fever. This disease presents acutely as a flu-like illness, although it can escalate to a chronic and often ... -
Virus interactions with the sphingolipid network : sphingosine kinase 2 in immunosuppression, immunopathology, and viral propagation
(University of Missouri--Columbia, 2020)Sphingosine 1-phosphate (S1P) is a bioactive lipid molecule known to regulate diverse cellular functions. S1P is metabolized by the sphingosine kinases (SphK) and S1P lyase (SPL). However, little is known about the role ...