• Alternative RNA processing and strategies to modulate splicing 

    Dickson, Alexa Megan (University of Missouri--Columbia, 2008)
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy (SMA) is a genetic disease that is intrinsically linked to an alternative RNA splicing event that leads a defective protein. ...
  • Hormonal regulation of innate immune responses and toll-like receptors in the human endometrium 

    Lange, Margaret J., 1981- (University of Missouri--Columbia, 2008)
    This study examines the role of the steroid hormones, estrogen (E2) and progesterone (P4) in the regulation of TLR3-mediated mucosal immune responses in the human reproductive tract. TLR3 expression in endometrial epithelium ...
  • Immunotherapy for autoimmune diabetes 

    Jain, Renu, 1979- (University of Missouri--Columbia, 2008)
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Type I diabetes (TID) or insulin-dependent diabetes mellitus (IDDM) is an immunemediated disease in which the beta ([beta]) cells of the pancreatic ...
  • Microbial pathogen contamination in mouse gametes and embryos 

    Zhang, Lin, 1974 Dec. 4- (University of Missouri--Columbia, 2008)
    Large numbers of transgenic and knockout mice have been generated. Cryopreservation provides an efficient and effective way to maintain these unique genetically modified rodent lines. However, there is a great risk of ...
  • Two aspects of peripheral immune tolerance : systemic and mucosal tolerance mechanisms 

    Divekar, Rohit Dilip, 1978- (University of Missouri--Columbia, 2008)
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Autoimmune diseases are a significant cause of human morbidity and mortality. The defects in immune system that lead to the pathogenesis of autoimmune ...