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Immunity in the newborn : control by IL-13 receptor and dendritic cells
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Neonates are susceptible to microbial infections and allergic reactions due to lack of Th1 immunity. Utilization of a TCR transgenic T cell transfer ...
Characterization of the role of adenovirus-5 (Ad-5) gene products E2A, E4ORF6 and VA RNA on adeno-associated virus type 5 (AAV5) transcription, translation and replication
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] AAV5 is the most distinct serotype of the AAVs differing from the prototype virus AAV2 at the nucleotide level. We show that in AAV5 the Rep transcripts ...
Hormonal regulation of innate immune responses and toll-like receptors in the human endometrium
(University of Missouri--Columbia, 2008)
This study examines the role of the steroid hormones, estrogen (E2) and progesterone (P4) in the regulation of TLR3-mediated mucosal immune responses in the human reproductive tract. TLR3 expression in endometrial epithelium ...
Regulating the regulators : using CD25 depletion to enhance immune responses to a model plasmid-based vaccine
(University of Missouri--Columbia, 2008)
Due to their ease of production and safety, plasmid-based vaccines have become prime candidates for both prophylactic and therapeutic human vaccination. In experimental animal models, vaccination with plasmid DNA expression ...
Alternative RNA processing and strategies to modulate splicing
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy (SMA) is a genetic disease that is intrinsically linked to an alternative RNA splicing event that leads a defective protein. ...
Development of gene therapy for Duchenne muscular dystrophy heart disease in the MDX mouse model
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Duchenne muscular dystrophy (DMD) is a fatal genetic muscle disease with no cure. DMD results from mutations in a critical muscle protein called ...
Exploring the cell surface : identification and characterization of lipoproteins in Mycoplasma mycoides subsp. mycoides large colony, Mycoplasma mycoides subsp. capri, and Mycoplasma capricolum subsp. capricolum
(University of Missouri--Columbia, 2009)
The Mycoplasma mycoides cluster is a group of genetically and antigenically related pathogenic bacteria that infect ruminants. The M. mycoides cluster members that are the focus of this discussion are three caprine pathogens: ...
Piecing together the Plasmodium falciparum genome puzzle : characterization of genes/proteins, PFE0565w and PF11_0394
(University of Missouri--Columbia, 2011)
Malaria is still a significant problem around the world and, thus, better control methods are in great need. A key stage in the Plasmodium life cycle is the sporozoite because it exhibits dual infectivity in both the ...
Investigating the role of germline RNA helicase-1 in Caenorhabditis elegans
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The germline specific RNA helicase GLH-1, a constitutive P-granule component, and DCR-1, the riboendonuclease responsible for processing small RNAs ...
Characterization of HIV-1 reverse transcriptase drug resistance connection subdomain mutation N348I
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Connection subdomain mutations are a recently discovered class of reverse transcriptase (RT) drug resistance mutations which are positioned at some ...
Role of Sds22 in the regulation of protein phosphatase-1 in Saccharomyces cerevisiae
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] GLC7 encodes the catalytic subunit of protein phosphatase 1 (PP1) in the budding yeast Saccharomyces cerevisiae. Glc7 binds different regulatory ...
Functional characterization of two putative mobile elements of the 'Mycoplasma mycoides cluster'
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Horizontal gene transfer has played a major role in bacterial evolution, including in the genus Mycoplasma, which is comprised of some of the simplest ...
Analysis of interactions between the germline RNA helicases (GLHs) and their regulators KGB-1 and CSN-5 in Caenorhabditis elegans
(University of Missouri--Columbia, 2006)
The Caenorhabditis elegans germline RNA helicases (GLHs) are constitutive components of P granules, non-membranous aggregates of protein and RNA that segregate with the nematode germline. The GLHs are critical for fertility. ...
Rational design of split gene vectors to expand the packaging capacity of adeno-associated viral vectors
(University of Missouri--Columbia, 2007)
Adeno associated viruses (AAV) have recently been demonstrated as a very promising gene delivery vehicle. But the limited packaging capacity of AAV vectors (4̃.7kb) hinders their application for diseases involving large ...
Transcription regulation of adeno-associated viruses
(University of Missouri--Columbia, 2007)
The small genome size of adeno-associated viruses demand efficient gene regulation achieved by various strategies. This research compared these strategies from AAV2, AAV5 and bovine-AAV, and found that AAV2 capsid promoter ...
Gene therapy in spinal muscular atrophy : RNA-based strategies to modulate the pre-mRNA splicing of survival motor neuron
(University of Missouri--Columbia, 2008)
Gene expression is the required process in eukaryotes in which DNA is transcribed into pre-mRNA, spliced to produce "mature" mRNA and translated into proteins. Inaccuracies in splicing events are receiving more attention ...
Characterization of cellular pathways in spinal muscular atrophy
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy (SMA) is an autosomal recessive genetic disease, and is the leading genetic cause of death in infants. SMA is a severe ...
Protein processing strategies by adeno-associated virus type 5 (AAV5) and the effects of the adenovirus E4orf6/E1b-55k/Cullin 5 E3 ubiquitin ligase complex on AAV protein stability
(University of Missouri--Columbia, 2008)
We report the initial identification of the ubiquitination of a parvovirus non-structural protein by the adenovirus E4orf6/E1b-55k/Cullin 5 E3 ubiquitin ligase complex. The small Rep and capsid proteins of adeno-associated ...
Serum resistance of an invasive nontypeable H. influenzae
(University of Missouri--Columbia, 2004)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Since the introduction of Haemophilus influenzae b polysaccharide-protein conjugate vaccines, the incidence of invasive H. influenzae disease dramatically ...
T cells from immunological memory to autoimmune disease
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] T cells are one of the key components of the acquired immune response. These cells are instrumental in fighting bacterial and viral infections. ...