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Interactions of porcine reproductive and respiratory syndrome virus with innate immune responses
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] North American field isolates of PRRSV differed in their type I IFN response with respect to induction, sensitivity and suppression. Furthermore, one ...
Micro-imaging characterization of mouse models of metastasis
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Non-invasive imaging techniques have been recently developed to characterize animal models of disease. The overarching hypothesis of this work explores ...
Advances in the fundamental cryobiology of mammalian oocytes
(University of Missouri--Columbia, 2007)
Having effective means to cryopreserve mammalian oocytes could increase the efficiency of managing populations of laboratory animals, increase the effectiveness of breeding programs for livestock, and improve the means by ...
The role of macrophages and anti-viral antibodies in West Nile virus pathogenesis
(University of Missouri--Columbia, 2006)
Since the introduction of West Nile virus into the United States in 1999, the virus has spread throughout the continental territory of the United States and it is suspected that the virus has moved present into Mexico and ...
Diagnosis, epidemiology and immunologic consequences of copper deficiency in calves
(University of Missouri--Columbia, 2006)
Copper is an essential micronutrient. Copper deficiency has been associated with disease states that decrease commercial beef production. Clinical manifestations of copper disease include anemia, diarrhea, long bone ...
Autologous bone marrow-derived mesenchymal stem cell transplantation as a therapy for neuronal ceroid lipofuscinosis
(University of Missouri--Columbia, 2007)
The Neuronal Ceroid Lipofuscinoses (NCLs) are a group of rare genetic diseases characterized by neurodegeneration and accumulation of autofluorescent lysosomal storage bodies in numerous cell types. There are currently no ...
A series of in vitro studies investigating the role of lactoferrin in calf innate immunity
(University of Missouri--Columbia, 2006)
Neonatal calf mortality rates continue to impact the economic sustainability of the United States cattle industry. Based on data generated from the National Animal Health Monitoring System survey in 2001, 8.9 % of dairy ...
Decreasing perinatal bovine leukosis virus infection in calves
(University of Missouri--Columbia, 2006)
Bovine leukosis virus (BLV) is an oncogenic retrovirus of cattle that causes lymphosarcoma in a proportion of infected individuals. Currently the United States estimates are that 44% of dairy cattle and 10% of beef cattle ...
Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis
(University of Missouri--Columbia, 2006)
Atherosclerosis is characterized by the narrowing of the arterial lumen due to formation of the plaque within the intimal layer of the arterial wall resulting in the impaired flow of blood to the target organs. Most severe ...
Mechanism of induction of vascular endothelial growth factor (vegf) in osteoarthritis
(University of Missouri--Columbia, 2006)
Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen and an angiogenic factor. Angiogenesis regulated by VEGF is a critical event in the pathogenesis of Osteoarthritis (OA). Over-expression of VEGF in ...
Phylogenetic characterization of canine distemper viruses detected in naturally infected North American dogs
(University of Missouri--Columbia, 2006)
In 2004, dogs with clinical signs suggestive of viral disease known as canine distemper virus (CD) were referred to the University of Missouri Veterinary Diagnostic Laboratory for testing. From eleven such cases, a diagnosis ...
Three mutations that cause fifferent [i.e. different] forms of canine neuronal ceroid lipofuscinosis
(University of Missouri--Columbia, 2006)
Neuronal ceroid-lipofuscinosis (NCL), also known as Battens disease, is really a group of inherited neurodegenerative diseases. A common feature of the ceroid lipofuscinoses is the deposition of autofluorescent cytoplasmic ...
The role of load in initiation and progression of cartilage pathology
(University of Missouri--Columbia, 2007)
Articular cartilage is primarily responsible for dissipation of load in diarthrodial joints. Load plays a critical role in maintaining cartilage health, but can also be a primary contributing factor in cartilage disease ...
Isolation, characterization, and diagnosis of murine noroviruses, a newly recognized pathogen of mice
(University of Missouri--Columbia, 2007)
Murine norovirus (MNV) is a newly recognized pathogen of mice. To assess the extent of MNV infection in laboratory mice, a high-throughput serologic diagnostic assay termed the multiplex fluorescent immunoassay (MFI) was ...
Characterization of the sporozoite and eythrocytic stages (SES) protein
(University of Missouri--Columbia, 2007)
The Plasmodium sporozoite is infective for mosquito salivary glands and vertebrate host tissues. Although it is a key developmental stage of the malaria parasite, relatively few sporozoite surface or secreted proteins have ...
DLC1 as a comparative epigenetic biomarker for radiotherapy of Non-Hodgkin's lymphoma
(University of Missouri--Columbia, 2007)
The American Cancer Society estimates that 58,870 people were diagnosed with non-Hodgkin's lymphoma (NHL) in 2006, and 18,840 people died of the disease. Recent investigation of epigenetic gene regulation has identified ...
Interaction of transcription factors in regulation of human chorionic gonadotropin (HCG) alpha subunit gene promoter activity
(University of Missouri--Columbia, 2009)
Chorionic Gonadotropin (CG), a glycoprotein hormone, is considered as a primary signal for maternal recognition of pregnancy in higher primates, including humans. CG is a heterodimer, consisting of an alpha subunit (CGA) ...
Use of the veterinary medical database to update the veterinary oncology literature
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In this dissertation we discuss the Veterinary Medical Database and how it can be used to perform epidemiological studies in the veterinary oncology ...
Characterization of interactions involving the polycystic kidney disease-causing proteins: SamCystin and Bicc1
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Rodent models, including the Han:SPRD-Cy rat and the jcpk mouse, have been useful for identifying and characterizing genes that cause Polycystic Kidney ...
Molecular genetics of spinal muscular atrophy : insights into various routes of therapeutic intervention
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy is an autosomal recessive neuromuscular disorder that is the leading genetic cause of infant mortality. In humans, a nearly ...