RSS 1.0Department of Biomedical Sciences (MU)
The Department of Biomedical Sciences is dedicated to the mission of the University through excellence in teaching, preeminence in scholarship and research, and a commitment to effective leadership in professional service. These goals are achieved through: daily contact with professional and graduate students involving didactic lectures, group interactions, and individual mentoring; significant contributions to science through innovative research; and, leadership roles in professional activities within the University, among local and state agencies, and at the National/International level in professional and scientific societies. The Department enjoys a well-earned reputation of excellence in both professional and graduate teaching. The faculty is dedicated to fulfilling its important role in the development of competent, successful, and respected DVM and Ph.D. graduates.
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Development and validation of animal models for fracture-related infection
(University of Missouri--Columbia, 2024)Fracture-related infections (FRIs) are a challenging complication in orthopaedics for all people and systems involved. The incidence of these infections is considerably high, particularly in open fractures. FRI management ... -
Comparison of four endotracheal tube cleaning protocols in anesthetized dogs
(University of Missouri--Columbia, 2024)The purpose of this dissertation is to review the evidence available for endotracheal tube (ETT) disinfection and compare the efficacy of four endotracheal tube cleaning protocols in a clinical population of anesthetized ... -
Retrospective evaluation of clinical parameters and survival characteristics in 137 dogs with reversed patent ductus arteriosus
(University of Missouri--Columbia, 2023)Background: Reversed patent ductus arteriosus (rPDA) is a comparatively rare form of canine congenital heart disease (CHD) and is defined by severe pulmonary arterial hypertension (PH), pulmonary-to-systemic shunting across ... -
Evaluating the molecular drivers of physical inactivity and muscle atrophy as initiating factors in cognitive impairment
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 8/1/2024] Physical activity has played an essential role in the evolution of humans and the development of the human brain. Therefore, it comes as no surprise that the modern-day pandemic levels of sedentarism ... -
Locoregional techniques for dogs undergoing tibial plateau leveling osteotomy : a literature review, anesthesiologist survey, and future directions
(University of Missouri--Columbia, 2023)Over the past several decades there have been significant advancements in our understanding and ability to provide effective analgesia to animals undergoing elective orthopedic surgery through methods that can help us ... -
Prolonged survival in 58 dogs with thyroid carcinoma treated with radioactive iodine as sole therapy
(University of Missouri--Columbia, 2023)Treatment of thyroid carcinomas in people and dogs often involves multimodal therapy, including radioactive iodine (I-131). The objective of this study is to describe outcomes associated with I-131 as sole therapy in dogs ... -
Using probiotics to modulate the asthmatic phenotype, respiratory microbiota, and immune responses in cats
(University of Missouri--Columbia, 2023)Feline asthma is associated with respiratory dysbiosis, correction of which could serve as novel treatment. We hypothesized that in asthmatic cats treated with anti-inflammatory glucocorticoids, probiotics would attenuate ... -
Fetoscopic in utero tracheal occlusion as a method to reduce fetal lung hypoplasia in a sheep model of congenital diaphragmatic hernia
(University of Missouri--Columbia, 2023)Congenital diaphragmatic hernia (DH) is a potentially fatal malformation that occurs in 1/2500 human births. Pulmonary hypoplasia decreases survival rate due to compression of thoracic contents by abdominal viscera. Previous ... -
Characterization of the impact of platelet-rich plasma and corticosteroid upon clinical and biochemical outcomes of knee osteoarthritis patients
(University of Missouri--Columbia, 2023)Introduction: There is no cure for symptomatic knee osteoarthritis (OA), and intra-articular injection is frequently used to provide symptomatic relief for patients of this debilitating disease. This study was performed ... -
Assessment of tibial morphologic alterations following correction of excessive tibial plateau angle in dogs
(University of Missouri--Columbia, 2023)Given the frequent addition of new techniques used to address cases of cranial cruciate ligament disease with excessive tibial plateau angle (eTPA), we sought to document the effect of popular surgical methods used to treat ... -
Evaluation of incisional gastropexy modified by addition of two full-thickness stomach to body wall sutures for prevention of gastric dilatation-volvulus
(University of Missouri--Columbia, 2023)Gastric dilatation-volvulus (GDV) is a common disease in large breed dogs. Its treatment involves medical management and surgical reposition of the stomach. To prevent the occurrence or recurrence of GDV, gastropexy is ... -
Cardiac biomarkers (NT-proBNP and cardiac troponin-I) and point-of-care ultrasound in dogs with cardiac and non-cardiac causes of non-hemorrhagic ascites
(University of Missouri--Columbia, 2023)Background: Non-hemorrhagic ascites (NHA) can be caused by cardiac diseases (cNHA) and non-cardiac diseases (ncNHA). N-terminal brain natriuretic peptide (NT-proBNP), cardiac troponin-I (cTnI) and point-of-care ultrasound ... -
Phase I clinical trial evaluating calcium electroporation for management of cutaneous tumors in dogs
(University of Missouri--Columbia, 2023)Traditionally, cutaneous tumors in dogs are managed with surgery, and adjuvant radiation therapy is considered in cases where complete resection is not achieved. Electrochemotherapy (ECT), with both cisplatin and bleomycin, ... -
Neonatal beef calf morbidity and mortality in Missouri
(University of Missouri--Columbia, 2022)Neonatal morbidity and mortality are major causes of economic loss for US beef cattle producers. The Missouri cattle industry represents 19 percent of the total agriculture sales in the state and is valued at 1.6 billion ... -
Diagnosis of aerodigestive disorders in dogs utilizing videofluoroscopic swallow study
(University of Missouri--Columbia, 2022)An aerodigestive disease (AeroD) is a disorder pathologically linking the respiratory and alimentary tracts. Dogs having respiratory signs without dysphagia, vomiting, or regurgitation typically lack diagnostics identifying ... -
The canine ocular surface microbiota
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Next generation sequencing (NGS) has been used to identify a diverse ocular surface (OS) microbiota in many species, highlighting limitations in ... -
The role of Cdc42 Rho GTPase in the cystic fibrosis intestinal epithelial barrier
(University of Missouri--Columbia, 2022)Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. People with CF and CF mouse models experience increased intestinal permeability, but the molecular mechanisms ... -
Intramammary infections in lactating Jersey cows: prevalence of pathogens and association of pathogen type with milk somatic cell count and persistence of infection
(University of Missouri--Columbia, 2022)There is limited data available regarding pathogens causing intramammary infections (IMI) in Jersey cows. The objectives of this study were to characterize the prevalence of IMI caused by different microorganisms in lactating ... -
Ventricle-specific fibrotic cardiac remodeling in the progression of heart failure with preserved ejection fraction
(University of Missouri--Columbia, 2022)Heart failure with preserved ejection fraction (HFpEF) is currently the most prominent form of heart failure (HF). Despite the rising prevalence over the last few years, the pathogenesis of this disease is still unknown. ... -
Relative HER2 protein expression in normal canine tissue and canine osteosarcoma
(University of Missouri--Columbia, 2022)Development of HER2-targeted immunotherapy in canine osteosarcoma (OSA) is underway, yet HER2 expression in normal and neoplastic canine tissue has not yet been defined. This study's objective was to evaluate the relative ...