RSS 1.0Biomedical Sciences electronic theses and dissertations (MU)
The items in this collection are the theses and dissertations written by students of the Department of Biomedical Sciences. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Columbia. Click on one of the browse buttons above for a complete listing of the works.
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Recent Submissions
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Evaluating the molecular drivers of physical inactivity and muscle atrophy as initiating factors in cognitive impairment
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 8/1/2024] Physical activity has played an essential role in the evolution of humans and the development of the human brain. Therefore, it comes as no surprise that the modern-day pandemic levels of sedentarism ... -
Locoregional techniques for dogs undergoing tibial plateau leveling osteotomy : a literature review, anesthesiologist survey, and future directions
(University of Missouri--Columbia, 2023)Over the past several decades there have been significant advancements in our understanding and ability to provide effective analgesia to animals undergoing elective orthopedic surgery through methods that can help us ... -
Prolonged survival in 58 dogs with thyroid carcinoma treated with radioactive iodine as sole therapy
(University of Missouri--Columbia, 2023)Treatment of thyroid carcinomas in people and dogs often involves multimodal therapy, including radioactive iodine (I-131). The objective of this study is to describe outcomes associated with I-131 as sole therapy in dogs ... -
Using probiotics to modulate the asthmatic phenotype, respiratory microbiota, and immune responses in cats
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Feline asthma is associated with respiratory dysbiosis, correction of which could serve as novel treatment. We hypothesized that in asthmatic cats treated with anti-inflammatory glucocorticoids, ... -
Fetoscopic in utero tracheal occlusion as a method to reduce fetal lung hypoplasia in a sheep model of congenital diaphragmatic hernia
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Congenital diaphragmatic hernia (DH) is a potentially fatal malformation that occurs in 1/2500 human births. Pulmonary hypoplasia decreases survival rate due to compression of thoracic contents ... -
Characterization of the impact of platelet-rich plasma and corticosteroid upon clinical and biochemical outcomes of knee osteoarthritis patients
(University of Missouri--Columbia, 2023)Introduction: There is no cure for symptomatic knee osteoarthritis (OA), and intra-articular injection is frequently used to provide symptomatic relief for patients of this debilitating disease. This study was performed ... -
Assessment of tibial morphologic alterations following correction of excessive tibial plateau angle in dogs
(University of Missouri--Columbia, 2023)Given the frequent addition of new techniques used to address cases of cranial cruciate ligament disease with excessive tibial plateau angle (eTPA), we sought to document the effect of popular surgical methods used to treat ... -
Evaluation of incisional gastropexy modified by addition of two full-thickness stomach to body wall sutures for prevention of gastric dilatation-volvulus
(University of Missouri--Columbia, 2023)Gastric dilatation-volvulus (GDV) is a common disease in large breed dogs. Its treatment involves medical management and surgical reposition of the stomach. To prevent the occurrence or recurrence of GDV, gastropexy is ... -
Cardiac biomarkers (NT-proBNP and cardiac troponin-I) and point-of-care ultrasound in dogs with cardiac and non-cardiac causes of non-hemorrhagic ascites
(University of Missouri--Columbia, 2023)Background: Non-hemorrhagic ascites (NHA) can be caused by cardiac diseases (cNHA) and non-cardiac diseases (ncNHA). N-terminal brain natriuretic peptide (NT-proBNP), cardiac troponin-I (cTnI) and point-of-care ultrasound ... -
Phase I clinical trial evaluating calcium electroporation for management of cutaneous tumors in dogs
(University of Missouri--Columbia, 2023)Traditionally, cutaneous tumors in dogs are managed with surgery, and adjuvant radiation therapy is considered in cases where complete resection is not achieved. Electrochemotherapy (ECT), with both cisplatin and bleomycin, ... -
Neonatal beef calf morbidity and mortality in Missouri
(University of Missouri--Columbia, 2022)[EMBARGOED UNTIL 12/1/2023] Neonatal morbidity and mortality are major causes of economic loss for US beef cattle producers. The Missouri cattle industry represents 19 percent of the total agriculture sales in the state ... -
Diagnosis of aerodigestive disorders in dogs utilizing videofluoroscopic swallow study
(University of Missouri--Columbia, 2022)[EMBARGOED UNTIL 12/1/2023] An aerodigestive disease (AeroD) is a disorder pathologically linking the respiratory and alimentary tracts. Dogs having respiratory signs without dysphagia, vomiting, or regurgitation typically ... -
The canine ocular surface microbiota
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Next generation sequencing (NGS) has been used to identify a diverse ocular surface (OS) microbiota in many species, highlighting limitations in ... -
The role of Cdc42 Rho GTPase in the cystic fibrosis intestinal epithelial barrier
(University of Missouri--Columbia, 2022)Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. People with CF and CF mouse models experience increased intestinal permeability, but the molecular mechanisms ... -
Intramammary infections in lactating Jersey cows: prevalence of pathogens and association of pathogen type with milk somatic cell count and persistence of infection
(University of Missouri--Columbia, 2022)[EMBARGOED UNTIL 8/1/2023] There is limited data available regarding pathogens causing intramammary infections (IMI) in Jersey cows. The objectives of this study were to characterize the prevalence of IMI caused by different ... -
Ventricle-specific fibrotic cardiac remodeling in the progression of heart failure with preserved ejection fraction
(University of Missouri--Columbia, 2022)[EMBARGOED UNTIL 8/1/2023] Heart failure with preserved ejection fraction (HFpEF) is currently the most prominent form of heart failure (HF). Despite the rising prevalence over the last few years, the pathogenesis of this ... -
Relative HER2 protein expression in normal canine tissue and canine osteosarcoma
(University of Missouri--Columbia, 2022)Development of HER2-targeted immunotherapy in canine osteosarcoma (OSA) is underway, yet HER2 expression in normal and neoplastic canine tissue has not yet been defined. This study's objective was to evaluate the relative ... -
A quantitative evaluation of DNA damage from irradiation of feline oral squamous cell carcinoma cells
(University of Missouri--Columbia, 2022)Feline oral squamous cell carcinoma is a locally invasive neoplasm that continues to carry a poor prognosis despite advances in multimodality oncologic treatment. Location, completeness of surgical excision or complete ... -
Mechanistic understanding and potential targets for mustard gas keratopathy
(University of Missouri--Columbia, 2022)Sulfur mustard gas (SM), a vesicating and alkylating agent, has been used as a warfare agent since World War I and recently in Syria. SM exposure causes severe corneal injury, pain, and irreversible blindness. The cornea ... -
Artificial neural network models utilize chamber-specific predictors of cardiac fibrosis in ovariectomized and aortic-banded Yucatan mini-swine
(University of Missouri--Columbia, 2022)[EMBARGOED UNTIL 6/1/2023] Objective: Heart failure with preserved ejection fraction (HFpEF) is a disease associated with significant clinical pathophysiological heterogeneity in which maladaptive cardiac fibrosis, in both ...