RSS 1.0Genetics Area Program electronic theses and dissertations (MU)
The items in this collection are the theses and dissertations written by students of the Genetics Area Program. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Columbia. Click on one of the browse buttons above for a complete listing of the works.
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Recent Submissions
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The identification of novel genes involved in copper and oxygen metabolism
(University of Missouri--Columbia, 2020)Copper (Cu) is an essential trace dietary metal which is also potentially toxic. Cells have evolved an intricate system of transporters and chaperones to carefully regulate Cu homeostasis. Cu uptake is mediated by the ... -
Leveraging large scale beef cattle genomic data to identify the architecture of polygenic selection and local adaptation
(University of Missouri--Columbia, 2020)Since the invention of the first array-based genotyping assay for cattle in 2008, millions of animals have been genotyped worldwide. Leveraging these genotypes offers exciting opportunities to explore both basic and applied ... -
Genomics of seasonal hair shedding and ecoregion-specific growth to identify environmentally-adapted beef cattle
(University of Missouri--Columbia, 2020)Recently, interest has increased in augmenting current national scale cattle evaluations with precision genetic predictions tailored to specific environmental conditions. Some efforts to develop environmentally-aware ... -
Aptamers against viral proteins as a tool to answer biological questions
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] There are two experimental chapters in this dissertation in which the fundamental questions center around aptamers and viruses and how these two ... -
Global DNA methylation analysis in relapsed Pre-B cell acute lymphoblastic leukemia
(University of Missouri--Columbia, 2019)Reliable biomarkers for relapsed acute lymphoblastic leukemia are scarce. Currently, minimal residual disease (MRD) is the best method in predicting a relapse event, but is invasive to the patient. In addition, high quantity ... -
Impact of sutherlandia frutescens on hepatic steatosis in high-fat fed rats
(University of Missouri--Columbia, 2018)Hepatic steatosis is closely associated with development of obesity and type II diabetes mellitus. Western medicine for these metabolic conditions is less accessible to many developing countries because of cost, availability ... -
Molecular control of endothelial cell polarization and tube formation by Ras superfamily GTPases
(University of Missouri--Columbia, 2015)The formation of blood vessels is a crucial step during early development so that newly formed tissues are able to undergo nutrient and gas exchange to support life. Fundamental to this process is the ability of endothelial ... -
The role of mTOR in SAF-1-mediated VEGF expression and breast cancer progression
(University of Missouri--Columbia, 2015)Breast cancer is a heterogeneous disease with a huge impact on the community evident from its high indices of morbidity and mortality worldwide. In recent years, research has been extensively directed toward unravelling ... -
Utilizing gene therapy methods to probe the genetic requirements to prevent spinal muscular atrophy /
(University of Missouri--Columbia, 2016)Spinal Muscular Atrophy is clinically recognized as a progressive weakness within the trunk and proximal limbs that will lead to breathing failure and death within infants. As a neurodegenerative genetic disease, SMA is ... -
Ex vivo gene therapy for the preservation of retinal and central nervous system structure and function in a canine model of CLN2 neuronal ceroid lipofuscinosis
(University of Missouri--Columbia, 2016)The neuronal ceroid lipofuscinoses (NCLs) are an inherited group of related lysosomal storage disorders. The NCLs are characterized in general by the accumulation of autofluorescent lysosomal storage material (ceroid-type ... -
Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy
(University of Missouri--Columbia, 2016)The genome of Canis lupus familiaris, the domestic dog, is an ideal tool for the study of inherited diseases. Its genome is uniquely suited for the mapping of genes that cause disease, and its reference genome has been ... -
Mapping natural and artificial selection events in animal genomes
(University of Missouri--Columbia, 2015)Selection events, of both artificial (human-imposed) and natural origin, have left their mark on animal genomes. These signatures are detectable through a variety of analyses and utilizing these types of studies in large ... -
Comparison of methods for partitioning training and validation populations to optimize prediction accuracy and enable across-breed genomic selection in beef cattle
(University of Missouri--Columbia, 2012)Across-breed genomic selection practices have the potential to revolutionize national genetic evaluation systems in the United States by including commercial cattle and increasing prediction power for hybrid animals. We ... -
Studies on the mechanisms of action of the male specific lethal complex in Drosophila
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Dosage compensation is achieved by a twofold up-regulation of the single X chromosome in male Drosophila. The inverse dosage effect produced by the ... -
Evolutionary relationships and signatures of selection in cattle established using genome-wide single nucleotide polymorphisms
(University of Missouri--Columbia, 2012)Although high-throughput single nucleotide polymorphism (SNP) microarray assays were primarily developed for association studies, they are a powerful tool in the study of evolution and population genetics. The applications ... -
Molecular genetic studies of canine inherited diseases
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The domestic dog has advantageous genome information ideal for mapping genes that cause disease. Humans share many diseases with dogs, which makes ... -
Regulation of BK virus DNA replication by transcription factors and noncoding RNAs
(University of Missouri--Columbia, 2011)Human polyomavirus BK (BKV) asymptomatically infects 80[about]90% of people during early childhood, and establishes a life-long persistent infection without causing overt clinical symptoms. High level BKV replication occurs ... -
Investigation of the biological role of the polycystic kidney disease protein bicaudal C (Bicc1) using comparative animal models
(University of Missouri--Columbia, 2009)Polycystic kidney disease (PKD) is a common inherited disorder affecting 600,000 Americans and more than 12 million people worldwide. Clinical manifestations include renal enlargement, abnormal tubular development and ... -
Genome scan in commercial angus cattle for quantitative trait loci influencing growth, carcass, and reproductive traits
(University of Missouri--Columbia, 2009)Experimental designs historically used for quantitative trait loci (QTL) mapping in cattle have captured a limited number of parental chromosomes and therefore have only detected the few heterozygous QTL within these ... -
Genetic basis of isoflavone accumulation during soybean seed development : special focus on water-deficit conditions
(University of Missouri--Columbia, 2009)Soybean (Glycine max [L] Merr.) seed isoflavones have long been considered a desirable trait to target in selection programs for their contribution to human health and plant defense systems. The plant synthesizes isoflavones ...