RSS 1.0Medical Pharmacology and Physiology electronic theses and dissertations (MU)
The items in this collection are the theses and dissertations written by students of the Department Medical Pharmacology and Physiology. Some items may be viewed only by members of the University of Missouri System and/or University of Missouri-Columbia. Click on one of the browse buttons above for a complete listing of the works.
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Recent Submissions
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The role of perivascular adipose tissue and infiltrating macrophages in vascular dysfunction with inflammatory bowel disease
(University of Missouri--Columbia, 2022)Historically, adipose tissue (AT) throughout the body has been categorized as either brown adipose tissue (BAT) or white adipose tissue (WAT). These categories are determined by color, physical characteristics, and ... -
Effects of mutant SHP2 expression on heart function in Duchenne muscular dystrophy
(University of Missouri--Columbia, 2022)[EMBARGOED UNTIL 8/1/2023] Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy that is caused by a mutation in the dystrophin gene which is located on the X chromosome. DMD affect 1 in 3,600 males at ... -
The role and mechanisms of ambient fine particulate matter exposure in cardiac dysfunction in mice
(University of Missouri--Columbia, 2022)[EMBARGOED UNTIL 8/1/2023] Ambient fine particulate matter (PM) exposure associates with an increased risk of cardiovascular diseases (CVDs). Oxidative stress and inflammation are considered important mechanisms for the ... -
Dystrophic cardiomyopathy: the role of myofilaments
(University of Missouri--Columbia, 2022)Dystrophic cardiomyopathy is the consequence of diseases that affect the protein dystrophin. Dystrophin forms part of the dystrophin glycoprotein complex and is postulated to act as a membrane stabilizer, protecting the ... -
Turning money into speech: campaign finance, political advertising, and the civic sphere
(University of Missouri--Columbia, 2022)In this dissertation, I trace the history of campaign finance reform's influence on political advertising. I track the discourses held within Congress and court hearings to uncover what I call the money-speech paradigm, ... -
Molecular regulation of sarcomere function
(University of Missouri--Columbia, 2021)Molecular regulation of striated muscle contraction is widely thought to be regulated through canonical thin filament mechanisms, i.e., Ca2+ activation of thin filaments. Dual filament regulation is a novel model of striated ... -
Cardiorespiratory abnormalities in early and advances stage mouse models of Duchenne muscular dystrophy
(University of Missouri--Columbia, 2021)Duchenne muscular dystrophy (DMD) is an X-linked severe muscle disease caused by dystrophin gene mutations affecting 1 in 3,500 newborn males worldwide every year. DMD is characterized by progressive skeletal muscle ... -
Adenosine deaminase acting on RNA (ADAR1) in the development of abdominal aortic aneurysm and atherosclerosis
(University of Missouri--Columbia, 2021)The main focus of this dissertation is the role of Adenosine deaminase acting on RNA (ADAR1) in the development of abdominal aortic aneurysm (AAA) and atherosclerosis. This first chapter of this document presents a review ... -
Mechanisms for chlorinated lipids in sepsis
(University of Missouri--Columbia, 2020)Sepsis induces the formation of proinflammatory chlorinated lipids, stimulates adhesive interactions between the endothelium and leukocytes/platelets, causes mast cell activation, disrupts the microvascular barrier and ... -
Contribution of TRPV4 to enhanced calcium cycling and cardiac arrhythmia following ischemia-reperfusion in aged mouse hearts
(University of Missouri--Columbia, 2020)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Cardiomyocyte Ca2+ homeostasis is altered with aging and predisposes the Aged heart to Ca2+ intolerance and arrhythmia. Transient Receptor ... -
Molecular mechanisms of action for CFTR potentiators
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] As the culprit behind cystic fibrosis (CF) is the dysfunction of the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR), ... -
TRPV4 contributes to stretch-induced hypercontractility and time-dependent dysfunction in the aged heart
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Aims: Cardiovascular disease remains the greatest cause of mortality in Americans over 65. The stretch-activated Transient Receptor Potential Vanilloid-4 ... -
Functional recovery of the microcirculation during skeletal muscle regeneration
(University of Missouri--Columbia, 2018)Skeletal muscle has a remarkable capacity to regenerate following injury, and although muscle regeneration has been studied extensively, little is known about the recovery of the skeletal muscle microcirculation during ... -
Sodium-Glucose Cotransporter 2 Inhibitors regulate vascular cell function
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Vascular disease is the major cause of morbidity and mortality in diabetic patients. Although numerous factors contribute to the development of ... -
Physiological and pharmacological characterization of the N1303K mutant CFTR
(University of Missouri--Columbia, 2018)Background: N1303K, one of the common, severe disease-causing mutations in the CFTR gene, causes both defective biogenesis and gating abnormalities of the CFTR protein. The goals of the present study are to quantitatively ... -
Integrin adhesion response to chemical and mechanical stimulation
(University of Missouri--Columbia, 2017)It is well recognized that arterial stiffness increases with aging and aging-related diseases, such as hypertension. The mechanisms for the increase in stiffness have been largely thought to be the result of changes in the ... -
Endothelial phenotype differs by both sex and vessel function
(University of Missouri--Columbia, 2017)Endothelial cells (the cells that line our blood vessels) were once thought to be an inert cellophane-like wrapper separating flowing blood from tissue. However, as our understanding of the human body has progressed, we ... -
Chlorinated lipid induce inflammatory responses in the microcirculation
(University of Missouri--Columbia, 2017)Previous studies from our research group have shown that chlorinated lipid, generated from the neutrophil-myeloperoxidase (MPO) system, are elevated in a rat sepsis model as well as in plasma of septic patients. Other work ... -
Dendritic cells contribute to perivascular adipose tissue dysfunction in type 2 diabetes
(University of Missouri--Columbia, 2017)T2DM is a chronic disease characterized by low-grade inflammation in adipose tissue. Recent investigations have shown that a variety of immune cells can accumulate in adipose tissue contributing to the development of chronic ... -
Myofibrillar regulatory mechanisms of stretch activation in mammalian striated muscle
(University of Missouri--Columbia, 2017)Stretch activation is described as a delayed increase in force after an imposed stretch. This process is essential in the flight muscles of many insects and is also observed, to some degree, in mammalian striated muscles. ...