• Comparing calcium handling in right and left ventricle cardiomyocytes in type III pulmonary hypertension 

  Shahid, Arooj (University of Missouri--Columbia, 2024)

  [EMBARGOED UNTIL 05/01/2025] Type III pulmonary hypertension (PH) is characterized by pulmonary fibrosis, leading to elevated pressure in the pulmonary arteries and hypertrophy of the right ventricle (RV). Yet, effects of ...

• Female sex protects cerebral arteries from mitochondrial membrane potential depolarization and cell death induced by reactive oxygen species 

  Safa (University of Missouri--Columbia, 2024)

  [EMBARGOED UNTIL 05/01/2025] Stroke, Alzheimer's disease, and traumatic brain injury exacerbate the production of reactive oxygen species (ROS), leading to apoptosis in cerebral arteries. Notably, females exhibit greater ...

• The impact of cadmium and nickel on non-small cell lung cancer progression in vitro analysis of tumor progression 

  Otoboh, Mary Omonyokan (University of Missouri--Columbia, 2024)

  [EMBARGOED UNTIL 05/01/2025] Lung cancer ranks among the primary contributors to cancer-related fatalities globally, affecting both men and women (Zhai et al., 2019). Lung cancer begins when healthy cells in the lungs ...

• The role of serum-glucocorticoid-regulated kinase (SGK1) in arterial reactivity 

  Nahar, Lutfun (University of Missouri--Columbia, 2023)

  Objective: In the vascular system, aldosterone exerts several actions via genomic and non-genomic pathways through MR receptor-dependent/independent mechanisms. Aldosterone exerts its effect by the transcription of target ...

• EC-SGK1 and EnNaC mediate vascular stiffening 

  Zhang, Liping (University of Missouri--Columbia, 2023)

  [EMBARGOED UNTIL 5/1/2024] Vascular stiffening is an independent predictor of cardiovascular diseases, the leading cause of death worldwide. High dietary salt intake has been shown to increase vascular stiffness in humans, ...

• Cardiomyocyte calcium and stress-induced ventricular arrhythmia 

  Haffner, Chidinma Vivian (University of Missouri--Columbia, 2023)

  [EMBARGOED UNTIL 5/1/2024] Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy and is caused by mutations in the dystrophin gene. Subclinical signs of cardiac disease present early and usually progress ...

• Role of plasminogen activator inhibitor-1 in the regulation of mitochondrial function in vascular smooth muscle cells 

  Schoenherr, Alex (University of Missouri--Columbia, 2023)

  Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor produced by vascular smooth muscle cells (VSMCs) and other cells, triggers metabolic dysfunction and cell senescence in obesity. Recent studies suggest ...

• The effect of lead on Renal cell carcinoma progression 

  Anderson, Haley Eileen (University of Missouri--Columbia, 2023)

  Renal cell carcinoma (RCC) incidence has been steadily increasing over the past few decades, and has become the ninth most common cancer in the United States. It has the highest mortality rate of the genitourinary cancers, ...

• The role of perivascular adipose tissue and infiltrating macrophages in vascular dysfunction with inflammatory bowel disease 

  Jenkins, Samuel Willis, III (University of Missouri--Columbia, 2022)

  Historically, adipose tissue (AT) throughout the body has been categorized as either brown adipose tissue (BAT) or white adipose tissue (WAT). These categories are determined by color, physical characteristics, and ...

• Effects of mutant SHP2 expression on heart function in Duchenne muscular dystrophy 

  Chatman, Erick (University of Missouri--Columbia, 2022)

  Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy that is caused by a mutation in the dystrophin gene which is located on the X chromosome. DMD affect 1 in 3,600 males at birth. Due to recent ...

• The role and mechanisms of ambient fine particulate matter exposure in cardiac dysfunction in mice 

  Liu, Xuanyou (University of Missouri--Columbia, 2022)

  Ambient fine particulate matter (PM) exposure associates with an increased risk of cardiovascular diseases (CVDs). Oxidative stress and inflammation are considered important mechanisms for the development and progression ...

• Dystrophic cardiomyopathy: the role of myofilaments 

  George, Thomas G. (University of Missouri--Columbia, 2022)

  Dystrophic cardiomyopathy is the consequence of diseases that affect the protein dystrophin. Dystrophin forms part of the dystrophin glycoprotein complex and is postulated to act as a membrane stabilizer, protecting the ...

• Molecular regulation of sarcomere function 

  Robinett, Joel (University of Missouri--Columbia, 2021)

  Molecular regulation of striated muscle contraction is widely thought to be regulated through canonical thin filament mechanisms, i.e., Ca2+ activation of thin filaments. Dual filament regulation is a novel model of striated ...

• Cardiorespiratory abnormalities in early and advances stage mouse models of Duchenne muscular dystrophy 

  Obi, Susan Ada (University of Missouri--Columbia, 2021)

  Duchenne muscular dystrophy (DMD) is an X-linked severe muscle disease caused by dystrophin gene mutations affecting 1 in 3,500 newborn males worldwide every year. DMD is characterized by progressive skeletal muscle ...

• Adenosine deaminase acting on RNA (ADAR1) in the development of abdominal aortic aneurysm and atherosclerosis 

  Cai, Dunpeng (University of Missouri--Columbia, 2021)

  The main focus of this dissertation is the role of Adenosine deaminase acting on RNA (ADAR1) in the development of abdominal aortic aneurysm (AAA) and atherosclerosis. This first chapter of this document presents a review ...

• Mechanisms for chlorinated lipids in sepsis 

  Yu, Hong (University of Missouri--Columbia, 2020)

  Sepsis induces the formation of proinflammatory chlorinated lipids, stimulates adhesive interactions between the endothelium and leukocytes/platelets, causes mast cell activation, disrupts the microvascular barrier and ...

• Contribution of TRPV4 to enhanced calcium cycling and cardiac arrhythmia following ischemia-reperfusion in aged mouse hearts 

  Peana, Deborah (University of Missouri--Columbia, 2020)

  [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Cardiomyocyte Ca2+ homeostasis is altered with aging and predisposes the Aged heart to Ca2+ intolerance and arrhythmia. Transient Receptor ...

• Molecular mechanisms of action for CFTR potentiators 

  Yeh, Han-I (University of Missouri--Columbia, 2019)

  [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI SYSTEM AT REQUEST OF AUTHOR.] As the culprit behind cystic fibrosis (CF) is the dysfunction of the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR), ...

• TRPV4 contributes to stretch-induced hypercontractility and time-dependent dysfunction in the aged heart 

  Veteto, Adam Bruce (University of Missouri--Columbia, 2019)

  [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] Aims: Cardiovascular disease remains the greatest cause of mortality in Americans over 65. The stretch-activated Transient Receptor Potential ...

• Functional recovery of the microcirculation during skeletal muscle regeneration 

  Fernando, Charmain Angela (University of Missouri--Columbia, 2018)

  Skeletal muscle has a remarkable capacity to regenerate following injury, and although muscle regeneration has been studied extensively, little is known about the recovery of the skeletal muscle microcirculation during ...

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