• The effects of 6-weeks of resistance training on the gut microbiome in young adults with overweight and obesity 

  Cullen, John (University of Missouri--Columbia, 2022)

  [EMBARGOED UNTIL 12/1/2023] INTRODUCTION: Obesity is a known risk factor for the development of insulin resistance, type 2 diabetes, and other cardiometabolic outcomes. Recently, the gut microbiome had been identified as ...

• Changes in blood biomarkers and the microbiome in individuals consuming a high and low fiber diet 

  Eley, Brendan Alexander (University of Missouri--Columbia, 2022)

  Dietary fiber is a group of polysaccharides consisting of long chains of various carbohydrate monomers than cannot be digested by the human body (1). High fiber diets are associated with decreases in body mass index, ...

• Role of adropin in arterial stiffening associated with obesity and type 2 diabetes 

  Jurrissen, Thomas III J. (University of Missouri--Columbia, 2022)

  Adropin is a peptide largely secreted by the liver and known to regulate energy homeostasis; however, it also exerts cardiovascular effects. Herein, I tested the hypothesis that low circulating levels of adropin in obesity ...

• Lifestyle treatment in the regression of NASH: insulin resistance, lipid synthesis, and methodological innovation 

  Mucinski, Justine M. (University of Missouri--Columbia, 2022)

  This dissertation is focused on factors that increase risk for nonalcoholic fatty liver disease (NALFD) and the more advanced form nonalcoholic steatohepatitis (NASH). These factors include postprandial lipid handling ...

• Investigating physical activity dispersion throughout recess to maximize activity on the playground: a baseline study 

  Emerson, Travis S. (University of Missouri--Columbia, 2022)

  Introduction: Obesity is an ongoing epidemic due to a surplus of caloric intake and a lack of physical activity (PA). Longitudinal data suggests that physical inactivity translates from childhood into adulthood. Therefore, ...

• The role of hepatic mitochondrial function and mitochondrial turnover in the development and progression of nonalcoholic fatty liver disease and lifestyle modifications to treat the disease 

  Moore, Mary Patricia (University of Missouri--Columbia, 2021)

  Nonalcoholic fatty liver disease (NAFLD) and its more advanced form steatohepatitis (NASH) is associated with obesity and is an independent risk factor for cardiovascular, liver-related, and all-cause mortality. Available ...

• The influence of menstrual cycle and oral contraceptive pill phases on the vascular response to hypoxia and sympathetic activation in healthy young women 

  Jacob, Dain Ward (University of Missouri--Columbia, 2021)

  INTRODUCTION: Hypoxia elicits peripheral vasodilation to preserve blood flow to metabolically active tissue and is accompanied by an increase in muscle sympathetic nervous system activity (MSNA). Prior data predominantly ...

• The impact of exercise on postural control in patients with Parkinson's disease measured by computerized dynamic posturography 

  Doctor, Elena Mae (University of Missouri--Columbia, 2021)

  Postural instability (PI) is one of the most debilitating symptoms of Parkinson's Disease (PD) that onsets in early stages of disease. The pathophysiology of PI occurs because of complex sensorimotor dysfunction that is ...

• Associations between client choice in food pantries and client food security status 

  Uchechi, Iyeghe Lilian (University of Missouri--Columbia, 2020)

  This study determined the relationship between client choice and client food security status, and how the relationship was affected by household type. Data was obtained from the Voices for Food Project. Among the various ...

• The role of TRAF3IP2 in obesity-associated vascular insulin resistance and dysfunction 

  Grunewald, Zachary I. (University of Missouri--Columbia, 2020)

  [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] Insulin resistance in the vasculature is a characteristic feature of obesity and contributes to the pathogenesis of vascular dysfunction and ...

• Influence of supervised activity zones during recess on sedentary activity, social skill development, and problem behavior in elementary-aged children 

  Barnas, Jillian L. (University of Missouri--Columbia, 2020)

  [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Due to the childhood obesity epidemic, many school-based interventions have been developed to target physical inactivity before it develops ...

• The brown adipose tissue phenoype : metabolic implications 

  Winn, Nathan C. (University of Missouri--Columbia, 2018)

  [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The prevailing dogma is that thermogenic brown adipose tissue (BAT) contributes to improvements in glucose homeostasis in obesogenic animal models; ...

• Investigating increased shear stress and physical activity as strategies to improve vascular insulin sensitivity 

  Walsh, Lauren K. (University of Missouri--Columbia, 2020)

  [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Impaired vasodilator actions of insulin in type 2 diabetes (T2D) result in blunted insulin-stimulated skeletal muscle capillary perfusion which limits ...

• Contribution of de novo lipogenesis to the progression of nonalcoholic fatty liver disease 

  Syed Abdul, Majid Mufaqam (University of Missouri--Columbia, 2020)

  This dissertation is focused on understanding the biochemical pathway of de novo lipogenesis (DNL) in humans and how changes in DNL can alter disease states, particularly nonalcoholic fatty liver disease (NAFLD). This ...

• Hormonal regulation of bone health: novel understandings of xenoestrogens and estrogen receptor-[alpha] 

  Dirkes, Rebecca (University of Missouri--Columbia, 2020)

  Estrogen is one of the most influential hormones on bone growth and maintenance throughout the life cycle in both men and women, but there are still unknown roles of estrogen and the estrogen receptors in males. In addition, ...

• The role of hepatocellular eNOS in NAFLD development and hepatic mitochondrial adaptations to exercise 

  Cunningham, Rory P. (University of Missouri--Columbia, 2020)

  Whole body loss of endothelial nitric oxide synthase (eNOS) worsens hepatic mitochondrial function and exacerbates nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) development and progression. However, the ...

• The role of estrogen receptor beta DNA binding domain in mediating adipose tissue and systemic metabolic effects of exercise in ovariectomized mice 

  Clart, Laura (University of Missouri--Columbia, 2020)

  [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Estradiol protects women from various cardiovascular and metabolic diseases, a protection which is lost with menopause when estradiol levels drop. ...

• Sleep, exercise, and insulin sensitivity 

  Porter, Jay W. (University of Missouri--Columbia, 2020)

  Accumulating evidence supports short sleep duration as a novel risk factor for obesity and diabetes, but little work has been done outside of healthy men or with consideration to changes in physical activity. Thirteen ...

• Association between urinary iodine concentrations and insulin resistance in US adults 

  Ezemaduka, Chisom (University of Missouri--Columbia, 2019)

  Background: Iodine intake within the US population has declined in recent years. Mild iodine deficiency increases the risk of inadequate thyroid hormone production and there is growing evidence that sub-clinical hypothyroidism ...

• Beta 3 adrenergic receptor activation rescues metabolic dysfunction in female estrogen receptor alpha-null mice 

  Clookey, S.L.; Welly, R.J.; Shay, D.; Woodford, M.L.; Fritsche, K.L.; Rector, R.S.; Padilla, J.; Lubahn, D.B.; Vieira-Potter, V.J. (Frontiers Media S.A., 2019)

  Metabolic disease risk escalates following menopause. The mechanism is not fully known, but likely involves reduced signaling through estrogen receptor alpha (ER[alpha]), which is highly expressed in brown and white adipose ...

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