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Transcriptome profiling of rattus norvegicus embryonic stem cells by RNA-sequencing
(University of Missouri--Columbia, 2014)
Embryonic Stem Cells (ESCs) are a critical tool for producing targeted knockout animals and understanding development. ESCs were successfully isolated from rats in 2008 and have been used in producing several targeted ...
Assessment of behavioral, neurochemical and developmental effects in developing rats following in utero exposure to non-teratogenic levels of 2,4-D and 2,4,5-T
(University of Missouri--Columbia, 1984)
The safe or non-teratogenic levels following prenatal exposure of animals to chlorophenoxy herbicides are currently based on offspring survival, growth and absence of anatomical defects or overt neurological impairment. ...
The use of sodium iodide for the management of bovine respiratory disease
(University of Missouri--Columbia, 2017)
Objective: The purpose of these studies was to (1) determine the effect of a single dose of oral sodium iodide on weaned beef calves and (2) determine the outcome of clinical application of a single dose of oral sodium ...
Angular limb deformities affecting the canine radius and ulna : classification using the center of rotation of angulation method
(University of Missouri--Columbia, 2015)
We hypothesized that 1) antebrachial ALDs would be more complex with respect to multiplicity in chondrodystrophic dogs, and 2) more complex ALDs would exhibit a higher incidence of concurrent joint radiographic disease. ...
The use of ventilator-acquired pulmonary mechanics and computed tomography in the assessment of interventions for experimental feline asthma
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In an experimental model of feline asthma, computed tomography (CT) and ventilator-acquired pulmonary mechanics were used in the assessment of various ...
Acute phase proteins in naturally occurring respiratory disease of feedlot cattle : a novel approach to diagnosisAcute phase proteins in naturally occurring respiratory disease of feedlot cattle : a novel approach to diagnosis
(University of Missouri--Columbia, 2014)
Bovine respiratory disease (BRD) is the most costly disease of feedlot cattle in the United States. Costs associated with BRD have been estimated from $13.90 to $15.57 per head with annual losses to the cattle industry ...
Biochemical characteristics of different subtypes of human immunodeficiency virus type 1 reverse transcriptase and its interactions with the host factor : apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Human immunodeficiency virus (HIV) is divided into type 1 (HIV-1) and type 2 (HIV-2). Whereas HIV-2 accounts for 5% of global infections, HIV-1 is ...
Relative HER2 protein expression in normal canine tissue and canine osteosarcoma
(University of Missouri--Columbia, 2022)
Development of HER2-targeted immunotherapy in canine osteosarcoma (OSA) is underway, yet HER2 expression in normal and neoplastic canine tissue has not yet been defined. This study's objective was to evaluate the relative ...
A quantitative evaluation of DNA damage from irradiation of feline oral squamous cell carcinoma cells
(University of Missouri--Columbia, 2022)
Feline oral squamous cell carcinoma is a locally invasive neoplasm that continues to carry a poor prognosis despite advances in multimodality oncologic treatment. Location, completeness of surgical excision or complete ...
In vitro and ex vivo therapeutic strategies for equine corneal fibrosis
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Purpose: The aims were to (1) To explore the impact of equine corneal fibroblast (ECF) to myofibroblast (ECM) differentiation by altering the expression ...
Analysis of platlet function in the setting of controlled trauma in dogs using a whole blood electrical impedance platelet aggregometer
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Post-traumatic hemorrhage remains one of the leading causes of human deaths, accounting for 30 to 56 percent of pre-hospital post-traumatic deaths. ...
Interaction of organophosphorus insecticide (Ciovap(R)) with phenothiazine anthelmintic in sheep with or without Haemonchus and Trichostrongylus species infection
(University of Missouri -- Columbia., 1981)
"This study was undertaken to examine the extent of cholinesterase inhibition and clinical effects of repeated topical application of the organophosphorus insecticide (Ciovap (R)) and the oral administration of phenothiazine ...
Locoregional techniques for dogs undergoing tibial plateau leveling osteotomy : a literature review, anesthesiologist survey, and future directions
(University of Missouri--Columbia, 2023)
Over the past several decades there have been significant advancements in our understanding and ability to provide effective analgesia to animals undergoing elective orthopedic surgery through methods that can help us ...
Therapeutic potential of the anti-fibrotic drug Suberanilohydroxamic acid (SAHA) in canine corneal fibrosis
(University of Missouri--Columbia, 2016)
Purpose: The aims were to (1) investigate the molecular mechanisms mediating the antifibrotic effect of SAHA in the canine cornea using an in vitro model and (2) to develop a novel in vivo model of corneal fibrosis in dogs ...
Neonatal beef calf morbidity and mortality in Missouri
(University of Missouri--Columbia, 2022)
Neonatal morbidity and mortality are major causes of economic loss for US beef cattle producers. The Missouri cattle industry represents 19 percent of the total agriculture sales in the state and is valued at 1.6 billion ...
Diagnosis of aerodigestive disorders in dogs utilizing videofluoroscopic swallow study
(University of Missouri--Columbia, 2022)
An aerodigestive disease (AeroD) is a disorder pathologically linking the respiratory and alimentary tracts. Dogs having respiratory signs without dysphagia, vomiting, or regurgitation typically lack diagnostics identifying ...
Prolonged survival in 58 dogs with thyroid carcinoma treated with radioactive iodine as sole therapy
(University of Missouri--Columbia, 2023)
Treatment of thyroid carcinomas in people and dogs often involves multimodal therapy, including radioactive iodine (I-131). The objective of this study is to describe outcomes associated with I-131 as sole therapy in dogs ...
Canine T-regulatory cells in aging and cancer : quantifying a unique T cell subset
(University of Missouri--Columbia, 2010)
T regulatory lymphocytes (Tregs), identified by the markers CD4, CD25, and FoxP3, are an essential part of the immune system and promote tolerance with the purpose of minimizing auto-immune disease. However, if Tregs are ...
The antiendotoxin effects of polymyxin B in a feline model of endotoxemia
(University of Missouri--Columbia, 2010)
Introduction: Directed, effective therapies for feline sepsis are needed to reduce the high morbidity and mortality associated with this disease. Materials and Methods: We investigated the anti-endotoxin effects of PMB in ...
Passive transfer of Mycoplasma bovis-specific antibodies in calves born to vaccinated dams
(University of Missouri--Columbia, 2006)
Mycoplasma bovis is a bacterial pathogen that has been shown to cause respiratory disease, mastitis, polyarthritis, keratoconjunctivitis, and other diseases in cattle worldwide. High costs associated with these diseases ...