Priority Updates from the Research Literature Surveillance system is a knowledge translation system called PURLS that exclusively targets newly published research expected to actually change family medicine and primary care practice. The PURLS system was developed in a collaborative partnership of the Family Physicians Inquiries Network (FPIN) and The Journal of Family Practice as an objective of the University of Chicago Institute for Translational Medicine, funded through a Clinical Translational Science Award from the National Institutes of Health.

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Recent Submissions

  • Antidepressant Tx for anxiety disorders: How long? 

    McGuire, Patricia; Castelli, Gregory (Family Physicians Inquiries Network, 2019)
    Antidepressant Tx for anxiety disorders: How long? This systematic review/meta-analysis provides some long-awaited evidence regarding the length of time to treat to minimize the risk of relapse. PRACTICE CHANGER: Keep ...
  • Do probiotics reduce C diff risk in hospitalized patients? 

    Simpson, Matthew; Lyon, Corey (Family Physicians Inquiries Network, 2019)
    Do probiotics reduce C diff risk in hospitalized patients? A systematic review and meta-analysis says, “Yes,” but that doesn’t necessarily mean they will start appearing on hospital formularies. Practice changer: Start ...
  • A better approach to the diagnosis of PE 

    Slattengren, Andrew H.; Prasad, Shailendra (Family Physicians Inquiries Network, 2019)
    A better approach to the diagnosis of PE: A simple diagnostic algorithm is all that’s needed to safely and effectively reduce our reliance on CT pulmonary angiography to diagnose PE. PRACTICE CHANGER: Do not order computed ...
  • Can vitamin D prevent acute respiratory infections? 

    Marshall, Bob; Bennett, Nick; Smith, Ashley; Robert, Oh; Burket, Jeffrey (Family Physicians Inquiries Network, 2019)
    Can vitamin D prevent acute respiratory infections? A systematic review and meta-analysis says Yes, but the dosages used may not be what you'd expect. PRACTICE CHANGER: Reduce acute respiratory tract infections in those ...
  • Should you switch the DAPT agent one month after ACS? 

    Ashby, Drew; Lyon, Corey (Family Physicians Inquiries Network, 2019)
    Should you switch the DAPT agent one month after ACS? A randomized controlled trial says “Yes,” but current guidelines say “No.” PRACTICE CHANGER: Switch to clopidogrel from one of the newer P2Y12 blockers 1 ...
  • Bariatric surgery plus medical therapy : effective Tx for T2DM? 

    Roberson, Kortnee Y.; Van Gompel, Emily White; Jarret, Jennie B. (Family Physicians Inquiries Network, 2019-03)
    Bariatric surgery + medical therapy: Effective Tx for T2DM? Short-term studies have indicated “Yes,” but does a longterm randomized controlled trial give it a thumbs up? PRACTICE CHANGER: Consider bariatric surgery with ...
  • How do these 3 diabetes agents compare in reducing mortality? 

    Martini, Jennifer; Coe, Catherine L.; Mounsey, Anne (Family Physicians Inquiries Network, 2019-03)
    How do these 3 diabetes agents compare in reducing mortality? A meta-analysis reveals that there may be advantages associated with SGLT-2 inhibitors and GLP-1 agonists that are not associated with DPP-4 inhibitors. PRACTICE ...
  • Less is more when it comes to ketorolac for pain 

    Lyon, Corey; Claus, Liza W. (Family Physicians Inquiries Network, 2019-02)
    Less is more when it comes to ketorolac for pain. It’s time to review our dosing with ketorolac for acute pain management. PRACTICE CHANGER: Using a low dose (10 mg) of intravenous ketorolac for moderate to severe acute ...
  • What’s the best treatment setting for stable PE patients? 

    Schaffer, Monica; Castelli, Gregory (Family Physicians Inquiries Network, 2018-12)
    What’s the best treatment setting for stable PE patients? The answer seems to be the outpatient setting. Here’s why. PRACTICE CHANGER: Manage patients with acute pulmonary embolism (PE) who are hemodynamically stable in ...
  • Should you reassess your patient’s asthma diagnosis? 

    Stevermer, James J.; Hayes, Alisa (Family Physicians Inquiries Network, 2018-11)
    Should you reassess your patient's asthma diagnosis? Asthma may not be a permanent diagnosis in adults. A study finds that up to one-third of adults with physician-diagnosed asthma no longer had it after 5 years. ...
  • Time to stop glucosamine and chondroitin for knee OA? 

    Lyon, Corey; Mullen, Rebecca; Ashby, Drew (Family Physicians Inquiries Network, 2018-09)
    Time to stop glucosamine and chondroitin for knee OA? Prior studies provided conflicting results regarding the efficacy of these medications. This study offers evidence for discontinuing them. Practice changer: Tell patients ...
  • Time to switch to nonsterile gloves for these procedures? 

    Castelli, Gregory; Friedlander, Mary Pat (Family Physicians Inquiries Network, 2018-08)
    Time to switch to nonsterile gloves for these procedures? Are sterile gloves worth the extra cost for common cutaneous surgeries? This systematic review and meta-analysis provides answers. Practice changer: Using nonsterile ...
  • First-time, mild diverticulitis: Antibiotics or watchful waiting? 

    Marshall, Bob; Prasad, Shailendra; Noel, Mary Alice; Burket, Jeffrey; Arnold, Michael; Arthur, Benjamin; Bennett, Nick; Smith, Ashley (Family Physicians Inquiries Network, 2018-07)
    First-time, mild diverticulitis: antibiotics or watchful waiting? Dn't jump to antibiotic Tx for mild, uncomplicated diverticulitis, a recent RCT says. Observation may be just as effective. Practice changer: For mild, ...
  • Let low-risk moms eat during labor? 

    Phelps, Karen; Davers, Justin; Seehusen, Dean A.; Stevermer, James J. (Family Physicians Inquiries Network, 2018-06)
    Let low-risk moms eat during labor? Allowing low-risk pregnant women to eat less restrictive diets during labor may not only make them happier, but may shorten labor, too. Practice changer: Allowing low-risk patients ...
  • A new protocol for RhD-negative pregnant women? 

    Lyon, Corey; English, Almee (Family Physicians Inquiries Network, 2018-05)
    Can cell-free DNA testing reduce unnecessary use of anti-D immunoglobulin in RhD-negative women and still prevent harm to their RhD-positive infants? PRACTICE CHANGER: Employ cell-free DNA testing at 27 weeks’ gestation ...
  • Treating migraines : it's different for kids 

    Hawks, Matthew; Mounsey, Anne (Family Physicians Inquiries Network, 2018-04)
    Treating migraines: It’s different for kids Certain medications used for migraine prevention in adults do not perform the same way in children and adolescents and can actually cause harm. PRACTICE CHANGER: Do not prescribe ...
  • An easy approach to obtaining clean-catch urine from infants 

    Morris, Laura (Family Physicians Inquiries Network, 2018-03)
    An easy approach to obtaining clean-catch urine from infants. Current collection methods leave much to be desired. But a new method may provide a quick alternative. Apply gauze soaked in cold sterile saline to the suprapubic ...
  • Does fish oil during pregnancy help prevent asthma in kids? 

    Neutze, Dana; Evans, Kelly Lacy; Koenig, Marianne; Castelli, Gregory; Mounsey, Anne (Family Physicians Inquiries Network, 2018-02)
    Does fish oil during pregnancy help prevent asthma in kids? The evidence on fish oil has been mixed, but this study affirms its benefits--in certain women. PRACTICE CHANGER: Fish oil supplementation taken by women in the ...
  • Tamsulosin for patients with ureteral stones? 

    Hughes, Pamela; Lyon, Corey (Family Physicians Inquiries Network, 2018-01)
    Tamsulosin for patients with ureteral stones? Yes, but only for some. Find out which of your patients can benefit. PRACTICE CHANGER: Prescribe tamsulosin for stone expulsion in patients with distal ureteral stones 5 to 10 ...
  • Does azithromycin have a role in cesarean sections? 

    Castelli, Gregory; Flaherty, Allison; Jarrett, Jennie B. (Family Physicians Inquiries Network, 2017-12)
    Does azithromycin have a role in cesarean sections? Yes, adding azithromycin to the usual antibiotic protocol in nonelective c-sections reduces infections. But not everyone can take advantage of it. PRACTICE CHANGER: ...

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