Can metformin undo weight gain induced by antipsychotics?
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Recommend metformin 250mg 3 times a day, along with lifestyle modifications, to promote weight loss and decrease insulin resistance in patients who gain more than 10% of their pretreatment body weight on antipsychotic medications. Strength of recommendation B: Based on a single, well-designed, randomized controlled trial.
Priority Updates to Research Literature (PURLs)
Journal of Family Practice, 57(8) 2008: 526-530.