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dc.contributor.authorPrather, Randall S.eng
dc.contributor.corporatenameUniversity of Missouri (System)eng
dc.contributor.meetingnameMissouri Life Sciences Summit (2010: University of Missouri--Kansas City)eng
dc.date.issued2000eng
dc.descriptionScientifically Led National Enterprises Paneleng
dc.descriptionDate of publication unknowneng
dc.descriptionDate of publication unknowneng
dc.description.abstractSwine have become important in biomedical research as they are excellent models for a variety of diseases including cardiovascular disease, atherosclerosis, cutaneous pharmacology, wound repair, cancer, diabetes, ophthalmology, toxicology research, lipoprotein metabolism, pathobiology of intestinal transport, injury and repair, as well as being considered potential sources of organs for xenotransplantation. Cystic Fibrosis (CF) is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR protein is responsible for chloride ion transport. Disruption of the function in humans results in meconium ileus, focal biliary cirrhosis, pancreatic destruction, liver lesions, and lung disease. Unfortunately disruption of this gene in mice, while affecting chloride transport, does not result in any of the symptoms that humans develop. In collaboration with the University of Iowa we have created pigs with either a knockout of the CFTR gene or a mutated version that is similar to 70% of the people with CF (ΔF508). These pigs are born with meconium ileus, focal biliary cirrhosis, pancreatic destruction, liver lesions and they develop lung disease. Finally there is a model to invasively study the development of CF, to monitor disease progression, and to develop treatments and therapies without experimenting on children with CF.eng
dc.identifier.urihttp://hdl.handle.net/10355/5460eng
dc.languageEnglisheng
dc.relation.ispartofcollectionAbstracts (Missouri Regional Life Sciences Summit 2010)eng
dc.relation.ispartofcommunityUniversity of Missouri System. Missouri Summits. Missouri Regional Life Sciences Summit 2010eng
dc.subjectmodels of diseaseeng
dc.subjectswineeng
dc.subjectcystic fibrosiseng
dc.subject.disciplineAnimal scienceseng
dc.subject.lcshCystic fibrosiseng
dc.subject.lcshSwine as laboratory animalseng
dc.subject.lcshAnimal models in researcheng
dc.titleGenetically Engineered Swine Models to Study Diseases like Cystic Fibrosiseng
dc.typePresentationeng


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