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dc.contributor.authorJohnson, Mark L. (Mark Louis)eng
dc.contributor.corporatenameUniversity of Missouri (System)eng
dc.contributor.meetingnameMissouri Life Sciences Summit (2010: University of Missouri--Kansas City)eng
dc.date.issued2010-03eng
dc.descriptionBiomedical Tissue Engineering - Where We Go in the Future Paneleng
dc.description.abstractThis presentation will examine the major role played by genetic studies in the identification of a fundamental pathway, the Wnt/β-catenin signaling pathway, and it's now appreciated multiple roles in bone cell biology. Specifically I will discuss how the genetic analysis of several families led to the discovery of this pathway and briefly summarize our work at understanding it's central role in the responsiveness of bone to mechanical loading. These studies have recently focused our attention on developing a better understanding of the strain environment within bone at the level of the osteocyte and how physical signals regulates the function of this bone cell. These fundamental studies will be of critical importance to our understanding of how to treat bone diseases such as osteoporosis and for the design of better scaffolds for use in fracture repair and bone regeneration.eng
dc.identifier.urihttp://hdl.handle.net/10355/5470eng
dc.languageEnglisheng
dc.relation.ispartofAbstracts (Missouri Regional Life Sciences Summit 2010)eng
dc.relation.ispartofcommunityUniversity of Missouri System. Missouri Summits. Missouri Regional Life Sciences Summit 2010eng
dc.subjectboneeng
dc.subjectosteoporosiseng
dc.subjectfracture healingeng
dc.subjectmechanical loadingeng
dc.subjectWnt/β-catenin signaling pathwayeng
dc.subject.lcshFractureseng
dc.subject.lcshOsteoporosiseng
dc.subject.lcshBoneseng
dc.titleNew Insights Revealed by Genetic Studies and the Future of Treating Bone Health Related Issueseng
dc.typePresentationeng


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