Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2008 Dissertations (MU)
    • 2008 MU dissertations - Freely available online
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2008 Dissertations (MU)
    • 2008 MU dissertations - Freely available online
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleSubjectIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleSubjectIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Phenotypically different cells in the nucleus of the solitary tract : expression of group I metabotropic glutamate receptors and activation by baroreflexes

    Austgen, James R. (James Robert), 1978-
    View/Open
    [PDF] public.pdf (2.023Kb)
    [PDF] short.pdf (5.298Kb)
    [PDF] research.pdf (3.758Mb)
    Date
    2008
    Format
    Thesis
    Metadata
    [+] Show full item record
    Abstract
    Modulation and integration of visceral and central afferent information occurs in the nucleus of the solitary tract (NTS). The NTS is a heterogeneous nuclear region that contains afferent terminals, interneurons, and multiple synaptic receptors that process information before exiting the NTS to multiple nuclear regions within the brain. One such efferent pathway is to the caudal ventrolateral medulla (CVLM), which serves as the second central nuclear region of the arterial baroreflex. The exact nature of the modulation of the arterial baroreflex at the level of the NTS is still unknown. The studies presented here further clarify the role of Group I metabotropic glutamate receptors (mGluRs) on GABAergic, nitroxidergic and catecholaminergic neurons and neurons the project from the NTS to the CVLM. Additionally, we examine GABAergic, nitroxidergic and catecholaminergic neurons and neurons the project from the NTS to the CVLM activated i n the NTS through acute hypertension and hypotension. Finally, we proposed a study to examine the expression of Group I mGluRs on neurons activated by hypertension and hypotension and neurons that project the NTS from the CVLM. These studies suggest that Group I mGluRs are preferentially expressed on CVLM projecting neurons, and that hypertension and hypotension activate separate populations of neuron in the NTS.
    URI
    https://doi.org/10.32469/10355/5518
    https://hdl.handle.net/10355/5518
    Degree
    Ph. D.
    Thesis Department
    Physiology (Medicine) (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • Medical Pharmacology and Physiology electronic theses and dissertations (MU)
    • 2008 MU dissertations - Freely available online

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems