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dc.contributor.authorBhaskaran, Sharanyaeng
dc.contributor.corporatenameUniversity of Missouri-Columbia. Office of Undergraduate Researcheng
dc.contributor.meetingnameUndergraduate Research and Creative Achievements Forum (2004 : University of Missouri--Columbia)eng
dc.date.issued2004eng
dc.descriptionAbstract only availableeng
dc.descriptionFaculty Mentor: Dr. Kattesh V. Katti, Chemistryeng
dc.description.abstractRadiopharmaceuticals are drugs with two components: a radioactive element that delivers a dose of radiation to detect or kill cancer cells targeted by the radiopharmaceutical and a targeting molecule that seeks out cancer sites. Effective radiopharmaceuticals could be used for both the diagnosis and treatment of diseases such as breast cancer, prostate cancer, and various other cancers. The ideal radiochemical properties (E = 140 KeV), its optimum half life (t1/2 = 6.02 h) and ready availability make Technetium-99m one of the most attractive radioisotopes for use in imaging applications. For a radiopharmaceutical to be useful and effective for use under in vivo conditions, it is imperative to have high kinetic stability for the Technetium compounds and its bioconjugates. This presentation includes recent results on the design of a new chelating system towards the overall objective of the design and development of in vivo stable 99mTc complexes. Specifically, the new ligand system comprises two electron donors (Sulfur and Nitrogen centers - MeSCH2CH(COOH)NH2 ). This ligand system upon interaction with Technetium carbonyl (i.e. Tc in the +1 oxidation state) produced a well defined Tc carbonyl SN complex as shown below in > 90% yields. The TcSN complex demonstrated in vitro stability at pH 5-7 as evidenced by High Performance Liquid Chromatography (HPLC) analysis. The new TcSN complex still contained one unoccupied coordination site on the metal. This free site may result in further reactions of the Tc metal center with active ligands. In order to improve the kinetic inertness of the TcSN complex, tris (hydroxymethy phosphine) THP, P(CH2OH)3, was introduced to fill in the available sixth coordination site. The resulting TcSNP complex demonstrated good in vitro stability at pH 5-7 for over 24 hours as evidenced by the HPLC analysis. Further studies to utilize the carboxylate arm in TcSNP complex for conjugations with tumor specific peptides are underway. The coordination chemistry, radiochemistry, and in vitro stability studies will be discussed.eng
dc.description.sponsorshipFunding source: Molecular Imaging Programeng
dc.identifier.urihttp://hdl.handle.net/10355/555eng
dc.publisherUniversity of Missouri--Columbia. Office of Undergraduate Researcheng
dc.relation.ispartof2004 Undergraduate Research and Creative Achievements Forum (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Office of Undergraduate Research. Undergraduate Research and Creative Achievements Forumeng
dc.source.urihttp://undergradresearch.missouri.edu/forums-conferences/abstracts/abstract-detail.php?abstractid=62eng
dc.subjectcancereng
dc.subjectTechnetium-99meng
dc.subjectligand systemeng
dc.subject.lcshTechnetium compoundseng
dc.subject.lcshRadiopharmaceuticalseng
dc.titleNew Tc-99m carbonyl complexes of SN bifunctional ligands [abstract]eng
dc.title.alternativeNew Technetium-99m carbonyl complexes of SN bifunctional ligandseng
dc.typeAbstracteng


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