An accelerated mouse model of inflammatory dry eye disease
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Meibomian glands (MGs) in eyelids (Fig. 1A) are enlarged sebaceous glands connected to hair follicles. The function of MGs is to secrete lipids which form the outer layer of the tear film of the eye (Fig. 1B). This layer maintains tear film stability by preventing tears from evaporating. Meibomian gland dysfunction (MGD) is a chronic abnormality of the Meibomian gland, commonly characterized by a change in the quantity or quality of the lipid secretion. MGD is among the most frequently diagnosed eye diseases and is a major cause of Dye Eye Disease (DED), but very little is known about the pathogenic processes leading to MGD and DED.