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    Study of anti-cancer effect of winter worm and summer grass on Mcf-7 human breast cancer cells

    Xu, Tongtong, 1977-
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    [PDF] research.pdf (1.499Mb)
    Date
    2008
    Format
    Thesis
    Metadata
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    Abstract
    Winter worm and summer grass (WWSG) is one of the most valued traditional Chinese medicines for fighting cancer, increasing longevity, and improving immunity. It consists of the entomopathogenic fungus Cordyceps sinensis and its natural lepidopteran host Hepialus armoricanus. Using the water extract of Cordyceps militaris, a sibling species of C. sinensis cultivated on an artificial host the silkworm Bombyx mori pupae, we have found that the C. militaris extract inhibited growth of MCF-7 human breast cancer cells in a dose- and time-dependent manner. The inhibitory effect of the C. militaris extract on MCF-7 cells was via an apoptosis cascade by inducing the expression of pro-apoptotic genes and by suppressing anti-apoptotic marker genes. Moreover, the C. militaris extract also inhibits DNA methyltransferase transcription, suggesting that the reduced cancer suppressor gene methylation might lead to the recovery of tumor-suppressor gene expression and eventually to the inhibition of tumor cell growth.
    URI
    https://doi.org/10.32469/10355/5619
    https://hdl.handle.net/10355/5619
    Degree
    M.S.
    Thesis Department
    Entomology (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • 2008 MU theses - Freely available online
    • Plant Sciences electronic theses and dissertations (MU)

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