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dc.contributor.advisorSong, Qishengeng
dc.contributor.authorXu, Tongtong, 1977-eng
dc.date.issued2008eng
dc.date.submitted2008 Springeng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on July 9, 2009)eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2008.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Entomology.eng
dc.description.abstractWinter worm and summer grass (WWSG) is one of the most valued traditional Chinese medicines for fighting cancer, increasing longevity, and improving immunity. It consists of the entomopathogenic fungus Cordyceps sinensis and its natural lepidopteran host Hepialus armoricanus. Using the water extract of Cordyceps militaris, a sibling species of C. sinensis cultivated on an artificial host the silkworm Bombyx mori pupae, we have found that the C. militaris extract inhibited growth of MCF-7 human breast cancer cells in a dose- and time-dependent manner. The inhibitory effect of the C. militaris extract on MCF-7 cells was via an apoptosis cascade by inducing the expression of pro-apoptotic genes and by suppressing anti-apoptotic marker genes. Moreover, the C. militaris extract also inhibits DNA methyltransferase transcription, suggesting that the reduced cancer suppressor gene methylation might lead to the recovery of tumor-suppressor gene expression and eventually to the inhibition of tumor cell growth.eng
dc.identifier.merlin.b70509396eng
dc.identifier.oclc423395329eng
dc.identifier.otherXuT-032009-T9962eng
dc.identifier.urihttp://hdl.handle.net/10355/5619eng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollection2008 Freely available theses (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2008 Theseseng
dc.subject.lcshMedicine, Chineseeng
dc.subject.lcshBreast -- Cancer -- Treatmenteng
dc.subject.lcshEntomopathogenic fungieng
dc.subject.lcshCordycepseng
dc.subject.lcshTumors -- Growtheng
dc.titleStudy of anti-cancer effect of winter worm and summer grass on Mcf-7 human breast cancer cellseng
dc.typeThesiseng
thesis.degree.disciplineEntomology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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