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dc.contributor.advisorSong, Qishengen_US
dc.contributor.authorXu, Tongtong, 1977-en_US
dc.date.issued2008eng
dc.date.submitted2008 Springen
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.en_US
dc.descriptionTitle from title screen of research.pdf file (viewed on July 9, 2009)en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2008.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Entomology.en_US
dc.description.abstractWinter worm and summer grass (WWSG) is one of the most valued traditional Chinese medicines for fighting cancer, increasing longevity, and improving immunity. It consists of the entomopathogenic fungus Cordyceps sinensis and its natural lepidopteran host Hepialus armoricanus. Using the water extract of Cordyceps militaris, a sibling species of C. sinensis cultivated on an artificial host the silkworm Bombyx mori pupae, we have found that the C. militaris extract inhibited growth of MCF-7 human breast cancer cells in a dose- and time-dependent manner. The inhibitory effect of the C. militaris extract on MCF-7 cells was via an apoptosis cascade by inducing the expression of pro-apoptotic genes and by suppressing anti-apoptotic marker genes. Moreover, the C. militaris extract also inhibits DNA methyltransferase transcription, suggesting that the reduced cancer suppressor gene methylation might lead to the recovery of tumor-suppressor gene expression and eventually to the inhibition of tumor cell growth.en_US
dc.identifier.merlin.b70509396en_US
dc.identifier.oclc423395329en_US
dc.identifier.otherXuT-032009-T9962en_US
dc.identifier.urihttp://hdl.handle.net/10355/5619
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartofcollection2008 Freely available theses (MU)
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2008 Theses
dc.subject.lcshMedicine, Chineseen_US
dc.subject.lcshBreast -- Cancer -- Treatmenten_US
dc.subject.lcshEntomopathogenic fungien_US
dc.subject.lcshCordycepsen_US
dc.subject.lcshTumors -- Growthen_US
dc.titleStudy of anti-cancer effect of winter worm and summer grass on Mcf-7 human breast cancer cellsen_US
dc.typeThesisen_US
thesis.degree.disciplineEntomologyen_US
thesis.degree.disciplineEntomologyeng
thesis.degree.grantorUniversity of Missouri--Columbiaen_US
thesis.degree.levelMastersen_US
thesis.degree.nameM.S.en_US


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