Study of anti-cancer effect of winter worm and summer grass on Mcf-7 human breast cancer cells

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Study of anti-cancer effect of winter worm and summer grass on Mcf-7 human breast cancer cells

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/5619

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dc.contributor.advisor Song, Qisheng en_US
dc.contributor.author Xu, Tongtong, 1977- en_US
dc.date.accessioned 2010-02-23T17:12:30Z
dc.date.available 2010-02-23T17:12:30Z
dc.date.issued 2008 en_US
dc.date.submitted 2008 Spring en
dc.identifier.other XuT-032009-T9962 en_US
dc.identifier.uri http://hdl.handle.net/10355/5619
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Title from title screen of research.pdf file (viewed on July 9, 2009) en_US
dc.description Includes bibliographical references. en_US
dc.description Thesis (M.S.) University of Missouri-Columbia 2008. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Entomology. en_US
dc.description.abstract Winter worm and summer grass (WWSG) is one of the most valued traditional Chinese medicines for fighting cancer, increasing longevity, and improving immunity. It consists of the entomopathogenic fungus Cordyceps sinensis and its natural lepidopteran host Hepialus armoricanus. Using the water extract of Cordyceps militaris, a sibling species of C. sinensis cultivated on an artificial host the silkworm Bombyx mori pupae, we have found that the C. militaris extract inhibited growth of MCF-7 human breast cancer cells in a dose- and time-dependent manner. The inhibitory effect of the C. militaris extract on MCF-7 cells was via an apoptosis cascade by inducing the expression of pro-apoptotic genes and by suppressing anti-apoptotic marker genes. Moreover, the C. militaris extract also inhibits DNA methyltransferase transcription, suggesting that the reduced cancer suppressor gene methylation might lead to the recovery of tumor-suppressor gene expression and eventually to the inhibition of tumor cell growth. en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.subject.lcsh Medicine, Chinese en_US
dc.subject.lcsh Breast -- Cancer -- Treatment en_US
dc.subject.lcsh Entomopathogenic fungi en_US
dc.subject.lcsh Cordyceps en_US
dc.subject.lcsh Tumors -- Growth en_US
dc.title Study of anti-cancer effect of winter worm and summer grass on Mcf-7 human breast cancer cells en_US
dc.type Thesis en_US
thesis.degree.discipline Entomology en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name M.S. en_US
thesis.degree.level Masters en_US
dc.identifier.merlin .b70509396 en_US
dc.identifier.oclc 423395329 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2008 Theses
dc.relation.ispartofcollection 2008 Freely available theses (MU)


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