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dc.contributor.advisorStoker, Aaron M.eng
dc.contributor.authorWerner, Nicole C.eng
dc.date.issued2016eng
dc.date.submitted2016 Springeng
dc.description.abstractOsteoarthritis (OA) is the most prevalent form of arthritis and is a significant cause of pain and disability worldwide. Treatment options available are only capable of controlling symptoms until progression to end-stage OA and qualifications for total knee replacement are met. To this regard, there is a strong need for the development of diagnostic tools and therapeutic interventions targeting earlier stages before irreversible damage occurs. It is generally accepted that changes in the structural orientation, biochemical parameters, and biomechanical properties together with inflammation are the main contributors to the development and progression of OA. Early stages of OA are characterized by alterations in the microscopic structure and microenvironment of the cartilage progressing to irreversible macroscopic tissue damage. Paralleling and in response to these changes, chondrocytes become activated, increasing the production of proteins involved in the degradation and synthesis of extracellular matrix (ECM) components and those involved in inflammation, which could serve as relevant biomarkers.eng
dc.identifier.urihttps://hdl.handle.net/10355/56290
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.titleAssessment of biomarker production by osteoarthritic osteochondral tissues and correlation to the biomechanical, biochemical, and histological propertieseng
dc.typeThesiseng
thesis.degree.disciplineVeterinary pathobiology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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