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dc.contributor.authorDeLucia, Valoryeng
dc.contributor.authorKelsberg, Garyeng
dc.contributor.authorSafranek, Saraheng
dc.date.issued2016-09eng
dc.description.abstractQ: Which SSRIs most effectively treat depression in adolescents? Evidence-based answer: We don' t know which selective serotonin reuptake inhibitors (SSRIs) are the most effective and safe because no studies have compared these antidepressants with each other. Three SSRI antidepressant medications--fluoxetine, sertraline, and escitalopram--produce modest improvements (about 5% to 10%) in standardized depression scores without a significant increase in the risk of suicide-related outcomes (suicidal behavior or ideation) in adolescent patients with major depression of moderate severity. As a group, however, the newer-generation antidepressants, including SSRIs, increase suicide-related outcomes by 50%. Citalopram, paroxetine, venlafaxine, and mirtazapine don' t improve depression scores (strength of recommendation [SOR]: A, meta-analyses of randomized controlled trials [RCTs]). An updated national guideline recommends specific psychological therapy for adolescents with mild depression and combined psychotherapy and fluoxetine for moderate or severe depression, with sertraline or citalopram as second-line agents (SOR: A, RCTs).eng
dc.identifier.citationJournal of Family Practice, 65(09) 2016: 632-634.eng
dc.identifier.urihttps://hdl.handle.net/10355/56517
dc.languageEnglisheng
dc.publisherFamily Physicians Inquiries Networkeng
dc.relation.ispartofseriesClinical inquiries, 2016eng
dc.relation.ispartofseriesJournal of Family Practice, vol. 65, no. 09 (2016)eng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.eng
dc.subjectdepression ; adolescents ; selective serotonin reuptake inhibitors ; SSRIs ; antidepressants ; fluoxetine ; sertraline ; escitalopram ; Citalopram ; paroxetine ;venlafaxine ; mirtazapine ; psychotherapy ; fluoxetineeng
dc.titleWhich SSRIs most effectively treat depression in adolescents?eng
dc.typeArticleeng


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