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dc.contributor.advisorJiJi, Renée Deniseeng
dc.contributor.authorSchmidt, Emily Anneng
dc.date.issued2008eng
dc.date.submitted2008 Summereng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from title screen of research.pdf file (viewed on August 14, 2009)eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2008.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Chemistry.eng
dc.description.abstractThe focus of this project is two-fold: examining the native structures of three different fragments of the beta-amyloid (A[beta]) peptide, and attempting to overcome some of the difficulties encountered in such an examination. The first part uses two different spectroscopic methods to compare the native structures of the hydrophilic [alpha beta] (1-16) fragment, the hydrophobic A[beta] (25-40) fragment, and the longer A[beta] (1-40) fragment. The second part focuses on replacing the counter-ion used in peptide purifications, including the purification of the A[beta] peptide, with a counter-ion that is less likely to alter the secondary structure and will not interfere with vibration-based spectroscopic studies. The third part highlights an attempt to improve upon current methods of peptide concentration estimation. Many experimental measurements require an accurate estimate of peptide concentration, which can prove to be particularly problematic for peptides such as A[beta] that are not easily soluble in aqueous solvents.eng
dc.identifier.merlinb70639061eng
dc.identifier.oclc430522543eng
dc.identifier.urihttps://hdl.handle.net/10355/5668
dc.identifier.urihttps://doi.org/10.32469/10355/5668eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2008 Freely available theses (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2008 Theseseng
dc.subject.lcshAmyloid beta-proteineng
dc.subject.lcshSpectrum analysiseng
dc.titleSpectroscopic investigations of the beta-amyloid peptideeng
dc.typeThesiseng
thesis.degree.disciplineChemistry (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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