Feeding studies of dietary diacylglycerol oil in normal and lipoprotein lipase-deficient cats

MOspace/Manakin Repository

Breadcrumbs Navigation

Feeding studies of dietary diacylglycerol oil in normal and lipoprotein lipase-deficient cats

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/5696

[+] show full item record


Title: Feeding studies of dietary diacylglycerol oil in normal and lipoprotein lipase-deficient cats
Author: Datz, Craig
Date: 2008
Publisher: University of Missouri--Columbia
Abstract: Diacylglycerol (DAG) oil has been investigated in humans and animals as a potential therapy for hypertriglyceridemia and related disorders. DAG oil was evaluated in healthy cats and in a feline model of hypertriglyceridemia as a result of lipoprotein lipase (LPL) deficiency. In the first study, eight adult cats were offered a commercial dry diet enriched with either DAG or triglyceride (TAG) oil (48% metabolizable energy [ME] from fat) in a two-bowl palatability feeding trial. After 14 days, total food intakes were similar (DAG diet 470 ± 52 g, TAG diet 380 ± 88 g, P = 0.4). Both diets were well-accepted and no changes in health or fecal quality were observed. In the second study, eleven adult LPL-deficient male cats were fed a semipurified diet containing either DAG or TAG oil as the sole fat source (25% ME) in a crossover design for 8 days each after a 21-day acclimation period. Serum concentrations of TAG, cholesterol, and nonesterified fatty acids were measured on days 6, 7, 8 and days 14, 15, 16. No significant effects were observed on any measurements, and a reduction in hypertriglyceridemia was not demonstrated (DAG: 3282 ± 400 mg/dl, TAG: 3001 ± 302 mg/dl). Dietary fat source did not significantly affect food intake, body weight, fecal quality, or general health. Further studies of DAG oil in cats are needed to evaluate long-term safety and benefits.
URI: http://hdl.handle.net/10355/5696
Other Identifiers: DatzC-121008-T11487

This item appears in the following Collection(s)

[+] show full item record