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    Feeding studies of dietary diacylglycerol oil in normal and lipoprotein lipase-deficient cats

    Datz, Craig
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    Date
    2008
    Format
    Thesis
    Metadata
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    Abstract
    Diacylglycerol (DAG) oil has been investigated in humans and animals as a potential therapy for hypertriglyceridemia and related disorders. DAG oil was evaluated in healthy cats and in a feline model of hypertriglyceridemia as a result of lipoprotein lipase (LPL) deficiency. In the first study, eight adult cats were offered a commercial dry diet enriched with either DAG or triglyceride (TAG) oil (48% metabolizable energy [ME] from fat) in a two-bowl palatability feeding trial. After 14 days, total food intakes were similar (DAG diet 470 [plus or minus]52 g, TAG diet 380 [plus or minus]88 g, P = 0.4). Both diets were well-accepted and no changes in health or fecal quality were observed. In the second study, eleven adult LPL-deficient male cats were fed a semipurified diet containing either DAG or TAG oil as the sole fat source (25% ME) in a crossover design for 8 days each after a 21-day acclimation period. Serum concentrations of TAG, cholesterol, and nonesterified fatty acids were measured on days 6, 7, 8 and days 14, 15, 16. No significant effects were observed on any measurements, and a reduction in hypertriglyceridemia was not demonstrated (DAG: 3282 [plus or minus]400 mg/dl, TAG: 3001 [plus or minus]302 mg/dl). Dietary fat source did not significantly affect food intake, body weight, fecal quality, or general health. Further studies of DAG oil in cats are needed to evaluate long-term safety and benefits.
    URI
    https://doi.org/10.32469/10355/5696
    https://hdl.handle.net/10355/5696
    Degree
    M.S.
    Thesis Department
    Veterinary medicine and surgery (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • 2008 MU theses - Freely available online
    • Veterinary Medicine and Surgery electronic theses and dissertations (MU)

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