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dc.contributor.advisorBackus, Roberteng
dc.contributor.authorDatz, Craigeng
dc.date.issued2008eng
dc.date.submitted2008 Falleng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionIncludes bibliographical references.eng
dc.description"December 2008"eng
dc.descriptionThesis (M.S.) University of Missouri-Columbia 2008.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary medicine and surgery.eng
dc.description.abstractDiacylglycerol (DAG) oil has been investigated in humans and animals as a potential therapy for hypertriglyceridemia and related disorders. DAG oil was evaluated in healthy cats and in a feline model of hypertriglyceridemia as a result of lipoprotein lipase (LPL) deficiency. In the first study, eight adult cats were offered a commercial dry diet enriched with either DAG or triglyceride (TAG) oil (48% metabolizable energy [ME] from fat) in a two-bowl palatability feeding trial. After 14 days, total food intakes were similar (DAG diet 470 ± 52 g, TAG diet 380 ± 88 g, P = 0.4). Both diets were well-accepted and no changes in health or fecal quality were observed. In the second study, eleven adult LPL-deficient male cats were fed a semipurified diet containing either DAG or TAG oil as the sole fat source (25% ME) in a crossover design for 8 days each after a 21-day acclimation period. Serum concentrations of TAG, cholesterol, and nonesterified fatty acids were measured on days 6, 7, 8 and days 14, 15, 16. No significant effects were observed on any measurements, and a reduction in hypertriglyceridemia was not demonstrated (DAG: 3282 ± 400 mg/dl, TAG: 3001 ± 302 mg/dl). Dietary fat source did not significantly affect food intake, body weight, fecal quality, or general health. Further studies of DAG oil in cats are needed to evaluate long-term safety and benefits.eng
dc.identifier.merlin.b7055920xeng
dc.identifier.oclc427376994eng
dc.identifier.otherDatzC-121008-T11487eng
dc.identifier.urihttp://hdl.handle.net/10355/5696eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2008 Freely available theses (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2008 Theseseng
dc.subject.lcshCats -- Diseases -- Diet therapyeng
dc.subject.lcshCats -- Foodeng
dc.subject.lcshHypertriglyceridemia -- Diet therapyeng
dc.subject.lcshDiglycerides -- Therapeutic useeng
dc.titleFeeding studies of dietary diacylglycerol oil in normal and lipoprotein lipase-deficient catseng
dc.typeThesiseng
thesis.degree.disciplineVeterinary medicine and surgery (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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