Feeding studies of dietary diacylglycerol oil in normal and lipoprotein lipase-deficient cats

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Feeding studies of dietary diacylglycerol oil in normal and lipoprotein lipase-deficient cats

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/5696

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dc.contributor.advisor Backus, Robert en_US
dc.contributor.author Datz, Craig en_US
dc.date.accessioned 2010-02-23T17:14:18Z
dc.date.available 2010-02-23T17:14:18Z
dc.date.issued 2008 en_US
dc.date.submitted 2008 Fall en
dc.identifier.other DatzC-121008-T11487 en_US
dc.identifier.uri http://hdl.handle.net/10355/5696
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Includes bibliographical references. en_US
dc.description "December 2008" en_US
dc.description Thesis (M.S.) University of Missouri-Columbia 2008. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Veterinary medicine and surgery. en_US
dc.description.abstract Diacylglycerol (DAG) oil has been investigated in humans and animals as a potential therapy for hypertriglyceridemia and related disorders. DAG oil was evaluated in healthy cats and in a feline model of hypertriglyceridemia as a result of lipoprotein lipase (LPL) deficiency. In the first study, eight adult cats were offered a commercial dry diet enriched with either DAG or triglyceride (TAG) oil (48% metabolizable energy [ME] from fat) in a two-bowl palatability feeding trial. After 14 days, total food intakes were similar (DAG diet 470 ± 52 g, TAG diet 380 ± 88 g, P = 0.4). Both diets were well-accepted and no changes in health or fecal quality were observed. In the second study, eleven adult LPL-deficient male cats were fed a semipurified diet containing either DAG or TAG oil as the sole fat source (25% ME) in a crossover design for 8 days each after a 21-day acclimation period. Serum concentrations of TAG, cholesterol, and nonesterified fatty acids were measured on days 6, 7, 8 and days 14, 15, 16. No significant effects were observed on any measurements, and a reduction in hypertriglyceridemia was not demonstrated (DAG: 3282 ± 400 mg/dl, TAG: 3001 ± 302 mg/dl). Dietary fat source did not significantly affect food intake, body weight, fecal quality, or general health. Further studies of DAG oil in cats are needed to evaluate long-term safety and benefits. en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2008 Freely available theses (MU) en_US
dc.subject.lcsh Cats -- Diseases -- Diet therapy en_US
dc.subject.lcsh Cats -- Food en_US
dc.subject.lcsh Hypertriglyceridemia -- Diet therapy en_US
dc.subject.lcsh Diglycerides -- Therapeutic use en_US
dc.title Feeding studies of dietary diacylglycerol oil in normal and lipoprotein lipase-deficient cats en_US
dc.type Thesis en_US
thesis.degree.discipline Veterinary medicine and surgery en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name M.S. en_US
thesis.degree.level Masters en_US
dc.identifier.merlin .b7055920x en_US
dc.identifier.oclc 427376994 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2008 Theses


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