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    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2016 Dissertations (MU)
    • 2016 MU dissertations - Freely available online
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    The cellular and humoral immune response against primary infection with Coxiella burnetii

    Schoenlaub, Laura Linn, 1988-
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    Date
    2016
    Format
    Thesis
    Metadata
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    Abstract
    Coxiella burnetii infection in mice results in a limited febrile illness that can be measured by examining splenomegaly, bacterial burden, and histopathology. In humans, this disease is known as Q fever. Using the mouse model, we examined both the T cell and the B cell response to primary infection with virulent C. burnetii. We discovered that Major Histocompatibility Complex class I and CD8+ Cytotoxic T cell lysis are critical for defense against primary infection. During the vaccine response, Major Histocompatibility Complex class II is essential for protective immunity. We also found that B1a B cells are important for producing cytokines and antibodies during primary infection. In addition, we discovered that avirulent C. burnetii induces caspase-1 dependent pyroptosis in murine B1a B cells. These studies build the foundation for better understanding of the immune response to C. burnetii infection and will hopefully lead to the development of new and more effective strategies for treating and preventing Q fever.
    URI
    https://hdl.handle.net/10355/56985
    https://doi.org/10.32469/10355/56985
    Degree
    Ph. D.
    Thesis Department
    Microbiology (Medicine) (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • 2016 MU dissertations - Freely available online
    • Molecular Microbiology and Immunology electronic theses and dissertations (MU)

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