dc.contributor.advisor | Zhang, Guoquan, 1966- | eng |
dc.contributor.author | Schoenlaub, Laura Linn, 1988- | eng |
dc.date.issued | 2016 | eng |
dc.date.submitted | 2016 Spring | eng |
dc.description | Abstract from short.pdf file. | eng |
dc.description | Dissertation advisor: Dr. Guoquan Zhang. | eng |
dc.description | Includes vita. | eng |
dc.description.abstract | Coxiella burnetii infection in mice results in a limited febrile illness that can be measured by examining splenomegaly, bacterial burden, and histopathology. In humans, this disease is known as Q fever. Using the mouse model, we examined both the T cell and the B cell response to primary infection with virulent C. burnetii. We discovered that Major Histocompatibility Complex class I and CD8+ Cytotoxic T cell lysis are critical for defense against primary infection. During the vaccine response, Major Histocompatibility Complex class II is essential for protective immunity. We also found that B1a B cells are important for producing cytokines and antibodies during primary infection. In addition, we discovered that avirulent C. burnetii induces caspase-1 dependent pyroptosis in murine B1a B cells. These studies build the foundation for better understanding of the immune response to C. burnetii infection and will hopefully lead to the development of new and more effective strategies for treating and preventing Q fever. | eng |
dc.description.bibref | Includes bibliographical references (pages 127-135). | eng |
dc.format.extent | 1 online resource (viii, 136 pages) : illustrations | eng |
dc.identifier.merlin | b11894034x | eng |
dc.identifier.oclc | 993881030 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/56985 | |
dc.identifier.uri | https://doi.org/10.32469/10355/56985 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.rights | OpenAccess. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | eng |
dc.subject.FAST | Coxiella burnetii | eng |
dc.subject.FAST | Immune response -- Research | eng |
dc.subject.FAST | T cells | eng |
dc.subject.FAST | B cells | eng |
dc.title | The cellular and humoral immune response against primary infection with Coxiella burnetii | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Microbiology (Medicine) (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Doctoral | eng |
thesis.degree.name | Ph. D. | eng |