EphB3 and EphA5 expression during motor axon outgrowth in the periphery [abstract]

MOspace/Manakin Repository

Breadcrumbs Navigation

EphB3 and EphA5 expression during motor axon outgrowth in the periphery [abstract]

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/575

[+] show full item record


Title: EphB3 and EphA5 expression during motor axon outgrowth in the periphery [abstract]
Author: Davenport, Bianca
Contributor: University of Missouri-Columbia. Office of Undergraduate Research
Keywords: motor axons
ephrins
in ovo electroporation
somites
Date: 2004
Publisher: University of Missouri - Columbia Office of Undergraduate Research
Abstract: During neural development, motor axons grow precisely to their final target regions to innervate muscle. We are interested in identifying the molecules that guide motor axons and understanding how they work. Members of the Eph family of receptor tyrosine kinases and their ligands, the ephrins, are thought to play key roles in motor axon guidance. Using chicken embryos, we are examining the expression of EphB3 and EphA5 during the stages that motor axons project through the somites to target limb muscles in the hindlimb. This analysis will guide our functional studies to determine the requirement for EphB3 and EphA5 in axon pathfinding. Functional analyses will include gain and loss-of-function experiments using in ovo electroporation to alter gene expression/ function. The results of these studies will provide important insights into how motor axons are guided to their target muscles during development.
URI: http://hdl.handle.net/10355/575

This item appears in the following Collection(s)

[+] show full item record