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dc.contributor.advisorLitofsky, N. Scott (Norman Scott), 1959-en_US
dc.contributor.advisorChandrasekhar, Anand, 1965-en_US
dc.contributor.authorKrug, Jeffrey Barten_US
dc.date.issued2008eng
dc.date.submitted2008 Fallen
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.en_US
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on September 25, 2009).en_US
dc.descriptionThesis advisors: Dr. N. Scott Litofsky & Dr. Anand Chandrasekhar.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionM.S. University of Missouri--Columbia 2008.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Neuroscience.en_US
dc.description.abstractImpaired functional abilities, especially those associated with ambulation and standing balance, are common sequelae of brain tumors. A majority of research regarding the effectiveness of surgery in treating individuals with brain tumor (BT) has measured length of survival, recurrence rate, and amount of tumor removed. Objective measurements of functional abilities and self-perceived overall health status (OHS) prior to and after surgery are important aspects of treatment, yet these areas have been inadequately studied. 9 adults with diagnosis of primary brain tumor were assessed prior to, immediately following, and at 3 months after surgery using the Timed Up-and-Go (TUG) and Tinetti Performance-Oriented Mobility Assessment (Tinetti) and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). Repeated measures ANOVA demonstrated significant differences in all outcome measures from pre- to immediately post-surgery with OHS (SF-36: df=1, F=6.3, p=0.04) and physical functioning (TUG: df=1, F=6.4, p=0.05; Tinetti: df=1, F=7.2, p=0.03) and from immediately post-surgery to 3 months post-surgery, ( SF-36: df=1, F=14.8, p=0.006; TUG: df=1, F=24.3, p=0.003; Tinetti: df=1, F=39.0, p<0.001). From pre-surgery to 3 months post-surgery, no significant difference was noted for any outcome measure (SF-36: df=1, F=2.3, p=0.18; TUG: df=1, F=0.03, p=0.86); Tinetti: df=1, F=3.4, p=0.11). All measures' post-surgery scores significantly correlated post-surgery. This included the two physical functioning measures (TUG and Tinetti) immediately post-surgery (r=-0.833, p=0.01) and 3 months post-surgery (r=-0.966, p=0.0). It also included the OHS and physical functioning measures: SF-36 and TUG (r=-0.762, p=0.028) and SF-36 and Tinetti immediately post-surgery (r=0.883, p=0.002); SF-36 and TUG (r=-0.845, p=0.004), and SF-36 and Tinetti 3 months post-surgery (r=0.849, p=0.004). Physical functioning and self-perceived OHS are closely linked. It is recommended that future studies of surgery for brain tumor use measures of physical functioning and OHS. The TUG, Tinetti, and SF-36 are appropriate for these purposes.en_US
dc.identifier.merlin.b71336953en_US
dc.identifier.oclc439880965en_US
dc.identifier.otherKrugJ-121008-T11711en_US
dc.identifier.urihttp://hdl.handle.net/10355/5754
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2008 Freely available theses (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2008 Theses
dc.subject.lcshBrain -- Tumors -- Surgeryen_US
dc.subject.lcshPostoperative careen_US
dc.titleFunctional outcome and self-perceived overall health status following surgery to remove primary brain tumoren_US
dc.typeThesisen_US
thesis.degree.disciplineNeuroscienceen_US
thesis.degree.disciplineNeuroscienceeng
thesis.degree.grantorUniversity of Missouri--Columbiaen_US
thesis.degree.levelMastersen_US
thesis.degree.nameM.S.en_US


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