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dc.contributor.advisorReinero, Carol R.eng
dc.contributor.authorBernhard, Christa L.eng
dc.date.issued2016eng
dc.date.submitted2016 Summereng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In an experimental model of feline asthma, computed tomography (CT) and ventilator-acquired pulmonary mechanics were used in the assessment of various conditions. Bronchoalveolar lavage (BAL) was performed to induce airflow limitation. First, it was hypothesized that the use of positive end-expiratory pressure (PEEP) at 2 cmH₂O or inspired oxygen concentration of 30% would improve pulmonary mechanics and decrease evidence of atelectasis compared with no PEEP or 100% O₂ in cats undergoing BAL. Secondly, it was hypothesized that heliox-driven nebulization of albuterol (heliox/albuterol) would lead superior reduction in airflow limitation and CT documented anatomic changes compared with heliox/saline, nitrox/albuterol or nitrox/saline 24 hrs post-allergen challenge and 5 minutes post-BAL. In the first study, the use of 30% inspired oxygen concentration failed to show any significant improvement in pulmonary mechanics but did diminish atelectasis. It was also associated with further desaturation of hemoglobin in some cats. The modest levels of PEEP employed were without effect on any of our outcome parameters. In the second study, heliox failed to demonstrate any benefit in terms of oxygenation, pulmonary mechanics, or CT features. As expected, nebulized albuterol improved peak airway pressure when compared with saline nebulization. In this study mechanical ventilation and the use of PEEP may have altered our outcome parameters, especially in regard to CT attenuation and portions of lung aeration.eng
dc.description.bibrefIncludes bibliographical references (pages 46-49).eng
dc.format.extent1 online resource (vii, 49 pages) : illustrationseng
dc.identifier.merlinb118608022eng
dc.identifier.oclc985510281eng
dc.identifier.urihttps://hdl.handle.net/10355/57619
dc.identifier.urihttps://doi.org/10.32469/10355/57619eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subject.FASTCats -- Diseases -- Treatmenteng
dc.subject.FASTAsthma -- Treatmenteng
dc.subject.FASTTomographyeng
dc.subject.FASTArtificial respirationeng
dc.titleThe use of ventilator-acquired pulmonary mechanics and computed tomography in the assessment of interventions for experimental feline asthmaeng
dc.typeThesiseng
thesis.degree.disciplineVeterinary medicine and surgery (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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