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    Regulating the regulators : using CD25 depletion to enhance immune responses to a model plasmid-based vaccine

    Thoma, Michelle C.
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    [PDF] short.pdf (7.844Kb)
    [PDF] research.pdf (654.6Kb)
    Date
    2008
    Format
    Thesis
    Metadata
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    Abstract
    Due to their ease of production and safety, plasmid-based vaccines have become prime candidates for both prophylactic and therapeutic human vaccination. In experimental animal models, vaccination with plasmid DNA expression vectors has been shown to induce robust cellular and humoral immune responses against a variety of infectious diseases and some cancers. However, DNA vaccines have proven to be weakly immunogenic in human clinical trials. The poor immunogenicity of DNA vaccines in humans necessitates the development of novel methods to enhance both cellular and humoral immune responses against the plasmid-encoded antigen(s). Previous in vivo studies have shown that CD4+CD25+Foxp3+ T regulatory cells can repress antigenspecific immune responses. We demonstrate here that depletion of CD25+ cells prior to plasmid vaccination significantly enhances primary and memory T cell responses and antibody responses to a model DNA vaccine against Lymphocytic choriomeningitis virus. If this approach can be safely applied to humans it may not only improve the clinical utility of DNA vaccines but also improve conventional vaccines as well.
    URI
    https://doi.org/10.32469/10355/5764
    https://hdl.handle.net/10355/5764
    Degree
    M.S.
    Thesis Department
    Microbiology (Medicine) (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • 2008 MU theses - Freely available online
    • Molecular Microbiology and Immunology electronic theses and dissertations (MU)

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