A Perfect Storm : Polycystic Ovary Syndrome Masking Underlying Type 1 Von Willebrand Disease
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Von Willebrand Disease (vWD) is the most common inherited bleeding diathesis worldwide and results in defects in von Willebrand Factor (vWF), inducing a hypocoagulable state. Polycystic Ovary Syndrome (PCOS) is characterized by chronic inflammation and hyperestrogenism, both of which induce acute phase reactions and increase serum levels of vWF and Factor VIII, yielding a prothrombotic state. These laboratory elevations may obscure the diagnosis of underlying vWD in patients with both conditions. We report a case of a 23 year-old female with PCOS and menorrhagia who presented prior to a surgical procedure for evaluation of bleeding risk.